MON-287 CORRELATION OF HBA1c AND URINE ALBUMIN CREATININE RATIO (UACR) WITH RENAL AND CARDIOVASCULAR HEALTH RISK FACTORS IN PATIENTS WITH DIABETES MELLITUS

Background Microalbuminuria represents vascular and endothelial dysfunction. Thyroid hormones can influence urine albumin excretion as it exerts crucial effects on the kidney and on the vascular system. This study explores the relationship between serum thyrotropin and urine albumin excretion in euthyroid patients with diabetes. Methods A total of 433 patients with type 1 or 2 diabetes were included in this retrospective cross-sectional study. Data included anthropometric measurements and biochemical parameters from diabetes clinic. Males with urine albumin creatinine ratio >2.5 and female’s >3.5 mg/mmoL were considered to have microalbuminuria. Results 34.9% of the patients had microalbuminuria. Prevalence of microalbuminuria increased according to TSH quartiles (26.9, 34.6, 38.5 and 44.9%, P for trend = 0.02). In a fully adjusted logistic regression model, higher TSH concentrations were associated with high prevalence of microalbuminuria (adjusted odds ratio 2.06 [95% CI: 1.14–3.72]; P = 0.02), while comparing the highest with the lowest quartile of TSH. Multiple linear regression analysis showed an independent association between serum TSH and urine albumin creatinine ratio (β = 0.007, t = 2.03 and P = 0.04). The risk of having microalbuminuria was higher with rise in TSH concentration in patients with younger age (<65 years), raised body mass index (≥25 kg/m2), hypertension, type 2 diabetes and hyperlipidaemia and age was the most important determinant ( P for interaction = 0.02). Conclusion Serum TSH even in the euthyroid range was positively associated with microalbuminuria in euthyroid patients with diabetes independent of traditional risk factors. This relationship was strongest in patients with components of the metabolic syndrome.

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Incident Chronic Kidney Disease Risk among Hispanics/Latinos in the United States: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Journal of the American Society of Nephrology ◽

10.1681/asn.2019101008 ◽

2020 ◽

Vol 31 (6) ◽

pp. 1315-1324

Author(s):

Ana C. Ricardo ◽

Matthew Shane Loop ◽

Franklyn Gonzalez ◽

Claudia M. Lora ◽

Jinsong Chen ◽

...

Keyword(s):

United States ◽

Risk Factors ◽

The United States ◽

Health Study ◽

Creatinine Ratio ◽

Albumin Creatinine Ratio ◽

Urine Albumin ◽

Hispanic Community ◽

Urine Albumin Creatinine Ratio ◽

Rate Ratios

BackgroundAlthough Hispanics/Latinos in the United States are often considered a single ethnic group, they represent a heterogenous mixture of ancestries who can self-identify as any race defined by the U.S. Census. They have higher ESKD incidence compared with non-Hispanics, but little is known about the CKD incidence in this population.MethodsWe examined rates and risk factors of new-onset CKD using data from 8774 adults in the Hispanic Community Health Study/Study of Latinos. Incident CKD was defined as eGFR <60 ml/min per 1.73 m2 with eGFR decline ≥1 ml/min per 1.73 m2 per year, or urine albumin/creatinine ratio ≥30 mg/g. Rates and incidence rate ratios were estimated using Poisson regression with robust variance while accounting for the study’s complex design.ResultsMean age was 40.3 years at baseline and 51.6% were women. In 5.9 years of follow-up, 648 participants developed CKD (10.6 per 1000 person-years). The age- and sex-adjusted incidence rates ranged from 6.6 (other Hispanic/mixed background) to 15.0 (Puerto Ricans) per 1000 person-years. Compared with Mexican background, Puerto Rican background was associated with 79% increased risk for incident CKD (incidence rate ratios, 1.79; 95% confidence interval, 1.33 to 2.40), which was accounted for by differences in sociodemographics, acculturation, and clinical characteristics. In multivariable regression analysis, predictors of incident CKD included BP >140/90 mm Hg, higher glycated hemoglobin, lower baseline eGFR, and higher baseline urine albumin/creatinine ratio.ConclusionsCKD incidence varies by Hispanic/Latino heritage and this disparity may be in part attributed to differences in sociodemographic characteristics. Culturally tailored public heath interventions focusing on the prevention and control of risk factors might ameliorate the CKD burden in this population.

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Urine Albumin Creatinine Ratio Among Diabetic Retinopathy Patient With And Without Diabetic Macular Edema In Moh. Hoesin Hospital Palembang

International Journal of Retina ◽

10.35479/ijretina.2018.vol001.iss001.32 ◽

2018 ◽

Vol 1 (1) ◽

Author(s):

Rina Astuti ◽

AK Ansyori ◽

Ramzi Amin

Keyword(s):

Risk Factors ◽

Diabetic Retinopathy ◽

High Density Lipoprotein ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Density Lipoprotein ◽

Creatinine Ratio ◽

Albumin Creatinine Ratio ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio

Introduction: Diabetic Macular Edema is a diffuse thickening in macula which can be found in various severity of Diabetic Retinopathy. There are issue about relationship between Diabetic Macular Edema and albuminuria caused by chronic renal failure. The aim of this study is to know and compare urine albumin creatinine ratio among Diabetic Retinopathy patients with and without Diabetic Macular Edema in Moh. Hoesin Hospital. Methods: Cross sectional study with 25 sample was conducted. Diabetic Retinopathy and Diabetic Macular Edema was classified base on Early Treatment Of Diabetic Retinopathy Study (ETDRS) criteria. T-test, odd ratio and multiple logistic regretion analysis was used to analysed sociodemography characteristic (age and gender), clinical characteristic (duration of DM, hipertension, treatment, body mass indeks and antioksidan consumption), ophtalmology characteristic (visus, anterior segment anomaly and posterior segment/ severity of Diabetic Retinopathy), laboratory characteristic (HbA1c, ureum, creatinine, urine albumin creatinine ratio, and lipid profile). Result: Urine albumin creatinine ratio mean (2146.77 ± 3796.19) in Diabetic Macular Edema and (49.0 ± 45.35) in non-Diabetic Macular Edema; cutoff point 62.00 mg/dL. Odd ratio adjusted for urine albumin creatinine ratio = 18,8. In this research, risk factors which has significantly were urine albumin creatinine ratio (p=0.047) and High-Density Lipoprotein/HDL (p=0.028) with odd ratio 8.571 and 6.67 respectively. Urine albumin creatinine ratio showed significantly high Mann whitney analysis 0.02 (p<0.005). Conclusion: Urine albumin creatinine ratio in Diabetic Retinopathy with Diabetic Macular Edema was higher than without Diabetic Macular Edema. Urine albumin creatinine ratio and High Density Lipoprotein (HDL) are the two important risk factors associated with Diabetic Macular Edema.

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Risk factors for development of nephropathy in patients with a diabetic Charcot foot

BMC Research Notes ◽

10.1186/s13104-021-05811-5 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Rasmus Bo Jansen ◽

Per E. Holstein ◽

Bo Jørgensen ◽

Klaus Kirketerp Møller ◽

Ole Lander Svendsen

Keyword(s):

Risk Factors ◽

Impaired Renal Function ◽

Rare Complication ◽

Total Duration ◽

Foot Deformities ◽

Creatinine Ratio ◽

Charcot Foot ◽

Albumin Creatinine Ratio ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio

Abstract Objective Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function. Results In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albumin/creatinine ratio in the group that received antibiotics (p = 0.017), and the use of antibiotics was associated to a subsequent diagnosis of nephropathy (p = 0.01). Patients treated with antibiotics had a 21.9% risk of developing subsequent nephropathy versus 5.2% for patients not treated with antibiotics. We suggest increased awareness on signs of nephropathy in patients with severe Charcot foot.

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Study of association between urine albumin creatinine ratio and ankle brachial index or peripheral arterial disease in type 2 diabetes mellitus patients

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20204071 ◽

2020 ◽

Vol 7 (10) ◽

pp. 1554

Author(s):

Puneet Saxena ◽

Deepak Chadha ◽

Rishika Goyal ◽

Adarsh Kenchappa Shanbogh

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Ankle Brachial Index ◽

Arterial Disease ◽

Creatinine Ratio ◽

Albumin Creatinine Ratio ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio ◽

Peripheral Arterial

Background: To establish association between urine albumin creatinine ratio and ankle brachial index or peripheral arterial disease in type 2 diabetes patients.Methods: Total 74 patients of type 2 diabetes mellitus of >50 years of age subjected to calculation of urine albumin creatinine ratio and ankle brachial index was calculated using doppler sonography and estimation of peripheral arterial diseases was done. The data obtained subjected to analysis.Results: In group with ABI <0.9 suggestive of PAD, mean age of the patient was 62.32±5.8 years, mean BMI was 26.11±2.48kg/m2, mean duration of diabetes was 11.19±41 years, 7 (18.92%) were smokers, 15 (40.54%) were insulin users, 27 (72.97%) were hypertensive, mean SBP was 142.49±13.46mmHg, mean DBP was 84±6.42mmHg, mean serum cholesterol was 221.35±17.10mg/dl, mean serum triglyceride was 242.81 ± 17.10mg/dl, mean serum HDL was 44.03±5.77mg/dl, mean serum LDL was 116.89±28.77mg/dl, mean urine ACR was 294.62±314.90mg/gm, prevalence of normoalbuminuria, microlbuminuria and macroalbuminuria was 12 (32.43%), 21 (56.76%) and 4 (10.81%) respectively. The statistical significant difference was found in age, duration of diabetes, number of patients on insulin therapy, systolic BP, serum cholesterol, triglyceride, LDL, HDL, urine ACR and distribution of albuminuria.Conclusions: we conclude that statistical significant relationship exist between urine ACR and PAD. Hence urinary ACR can be considered as surrogate marker for early prediction of PAD in elderly patients with type 2diabetes mellitus eventually leading to aggressive intervention for prevention and management.

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Association between urine albumin creatinine ratio and high sensitivity C-reactive protein in patients with type 2 diabetes mellitus

International Journal of Clinical Biochemistry and Research ◽

10.18231/2394-6377.2018.0081 ◽

2018 ◽

Vol 5 (3) ◽

pp. 386-391

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

High Sensitivity ◽

Creatinine Ratio ◽

C Reactive Protein ◽

Albumin Creatinine Ratio ◽

Reactive Protein ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio

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CORRELATION OF URINE N-ACETYL-BETA-D-GLUCOSAMINIDASE ACTIVITY WITH URINE ALBUMIN CREATININE RATIO IN TYPE 2 DIABETES MELLITUS (Kenasaban Aktivitas N-Asetil-Beta-D-Glukosaminidase Air Kemih dengan Air Kemih Albumin Kreatinin Rasio di Diabetes Melitus Tipe 2)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v23i3.1207 ◽

2018 ◽

Vol 23 (3) ◽

pp. 275

Author(s):

Melly Ariyanti ◽

Lillah Lillah ◽

Ellyza Nasrul ◽

Husni Husni

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Creatinine Ratio ◽

Albumin Creatinine Ratio ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio ◽

Diabetes Melitus

Urine Albumin Creatinine Ratio (UACR) merupakan metode untuk mengukur mikroalbuminuria, petanda awal dan paling banyakdigunakan untuk diagnosis nefropati diabetes. N-asetil-beta-d-glukosaminidase (NAG) air kemih adalah enzim lisosom dengan beratmolekul besar sehingga tidak difiltrasi oleh glomerulus. Ekskresi NAG di air kemih sangat mudah terganggu terutama oleh filtrasialbumin. Tujuan penelitian ini untuk mengetahui kenasaban NAG air kemih dengan UACR di pasien DM tipe 2. Penelitian ini merupakanpenelitian analitik dengan rancangan potong lintang terhadap 25 pasien DM tipe 2 yang berobat ke Poliklinik Endokrin Penyakit DalamRSUP Dr. M. Djamil Padang. Penelitian dilakukan mulai bulan Januari 2016–September 2016. Albumin air kemih diukur denganmetode imunoturbidimetri, kreatinin air kemih dengan metode Jaffe dan NAG dengan Enzyme-Linked Immune Sorbent Assay (ELISA).Kenasaban Spearman dilakukan untuk mengetahui hubungan aktivitas NAG air kemih dan UACR. Penelitian ini terdiri dari laki-laki68% dan perempuan 32%. Rerata umur 56,16±7,6 tahun dengan rentang 39–67 tahun. Kadar glukosa, ureum dan kreatinin serumberturut-turut, 148±49 mg/dL, 24±6,2 mg/dL dan 0,9±0,3 mg/dL. Normoalbuminuria sebanyak 80% dan mikroalbuminuria 20%.Median nilai UACR pasien DM tipe 2 adalah 6,02 (16,46) mg/g dengan rentang 1,53–119,41 mg/g dan rerata kadar NAG adalah51,01±31,88 ng/mL dengan rentang 9,45–144,38 ng/mL. Uji kenasaban Spearman menunjukkan kenasaban yang kuat antara aktivitasNAG air kemih dengan UACR dengan r=0,614 dan p<0,05. Terdapat kenasaban yang kuat antara aktivitas NAG air kemih denganUACR di pasien DM tipe 2.

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