Triboelectric charging of a glass bead impacting against polymers: Antistatic effects in glass/PU electrification in a humidity-controlled environment

SummaryDipyridamole (Persantin) is reported to prolong platelet survival and inhibit embolism in patients with prosthetic heart valves, but its mechanism of action is unknown. Fifty jxM dipyridamole failed to reduce the high percentage of platelets retained when heparinized human blood was passed through a glass bead column, but prolonged the inhibition of retention caused by disturbing blood in vitro. Possibly the prostheses act like disturbance. Although RA 233 was as effective as dipyridamole in inhibiting the return of retention, it was less effective in preventing the uptake of adenosine into erythrocytes, and more active in inhibiting ADP-induced aggregation and release. Thus there is no simple relation between these drug effects.

Download Full-text

Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648055 ◽

1976 ◽

Vol 36 (02) ◽

pp. 401-410 ◽

Cited By ~ 6

Author(s):

Buichi Fujttani ◽

Toshimichi Tsuboi ◽

Kazuko Takeno ◽

Kouichi Yoshida ◽

Masanao Shimizu

Keyword(s):

Guinea Pig ◽

Acetylsalicylic Acid ◽

Guinea Pigs ◽

Glass Bead ◽

Animal Species ◽

Inhibitory Effect ◽

Rabbit Platelet ◽

Platelet Adhesiveness

SummaryThe differences among human, rabbit and guinea-pig platelet adhesiveness as for inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid are described, and the influence of measurement conditions on platelet adhesiveness is also reported. Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column. Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the inhibitory effect in guinea-pigs, but not in rabbits.

Download Full-text

Non-Thrombogenicity of Clean Glass Revealed by Native Whole Blood Assay in Bead Columns

Thrombosis and Haemostasis ◽

10.1055/s-0038-1665319 ◽

1983 ◽

Vol 50 (04) ◽

pp. 814-820 ◽

Cited By ~ 1

Author(s):

J A Bergeron ◽

J M DiNovo ◽

A F Razzano ◽

W J Dodds

Keyword(s):

Whole Blood ◽

Glass Bead ◽

Factor Xii ◽

Platelet Factor ◽

Serotonin Content ◽

Whole Blood Assay ◽

Vascular Integrity ◽

Blood Assay ◽

Standard Contact ◽

Recalcification Time

SummaryThe previously described native whole blood assay for materials in solution or suspension has been adapted to materials in a bead column configuration. These experiments showed that the glass itself accounts for little or none of the high blood-reactivity observed with conventional glass bead columns. Columns composed solely of soft glass that was “cleaned” by heat treatment (500-595° C 18 hr, electric oven) were benign toward flowing native whole blood for all variables measured (platelet count and platelet-free plasma [C14]-serotonin content, platelet factor 3 and factor XII activities, and recalcification time) with the standard contact protocol. In addition, the effluent successfully maintained perfusion of the isolated kidney, a measure of the ability of platelets to support vascular integrity. Prolonged (30 min) normothermic contact with titrated whole blood increased the subsequent reactivity of initially clean glass toward whole blood albeit to a level much less than that of conventional glass bead columns.

Download Full-text

Controlled environment storage cabinet for processed thermolabile endoscopes

10.3403/30248649 ◽

2015 ◽

Keyword(s):

Controlled Environment

Download Full-text

Faculty Opinions recommendation of Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation -- a comparison in a controlled environment.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717995431.793474923 ◽

2013 ◽

Author(s):

David Alpers

Keyword(s):

Clinical Trial ◽

Chronic Constipation ◽

Randomised Clinical Trial ◽

Controlled Environment

Download Full-text

Minimal Transmission in an Influenza A (H3N2) Human Challenge-Transmission Model with Exposure Events in a Controlled Environment

SSRN Electronic Journal ◽

10.2139/ssrn.3457429 ◽

2019 ◽

Author(s):

Jonathan S. Nguyen-Van-Tam ◽

Ben Killingley ◽

Joanne Enstone ◽

Michael Hewitt ◽

Jovan Pantelic ◽

...

Keyword(s):

Influenza A ◽

Transmission Model ◽

Controlled Environment

Download Full-text

Magnetic Digital Microfluidics for Point-of-Care Testing: Where Are We Now?

Current Medicinal Chemistry ◽

10.2174/0929867327666200903115448 ◽

2020 ◽

Vol 27 ◽

Author(s):

Yi Zhang

Keyword(s):

System Integration ◽

Diagnostic Tests ◽

Point Of Care ◽

Digital Microfluidics ◽

Controlled Environment ◽

Point Of Care Testing ◽

Microfluidic Platforms ◽

Interface System ◽

Technical Issues ◽

Sample System

: Point-of-care (POC) testing decentralizes the diagnostic tests to the sites near the patient. Many POC tests rely microfluidic platforms for sample-to-answer analysis. Compared to other microfluidic systems, magnetic digital microfluidics demonstrate compelling advantages for POC diagnostics. In this review, we have examined the capability of magnetic digital microfluidics-based POC diagnostic platforms. More importantly, we have categorized POC settings into three classes based on “where is the point”, “who to care” and “how to test”, and evaluated the suitability of magnetic digital microfluidics in various POC settings. Furthermore, we have addressed other technical issues associated with POC testing such as controlled environment, sample-system interface, system integration and information connectivity. We hope this review would provide a guideline for the future development of magnetic digital microfluidics-based platforms for POC testing.

Download Full-text