Household use of polluting cooking fuels and late-life cognitive function: A harmonized analysis of India, Mexico, and China

BackgroundCausal relationships between vascular factors and late-life depression are controversial.AimsTo investigate prospective associations between risk factors for vascular disease and incidence of late-life depression.MethodOf 661 community participants aged 65 years or over, without depression at baseline, 521 (79%) were re-evaluated 2 years later. At baseline and follow-up, a diagnostic interview for depression was carried out and information on vascular status, disability and cognitive function was gathered.ResultsPre-existing heart disease, incident stroke and lower baseline high-density lipoprotein cholesterol level were significantly associated with incidence of late-life depression, independently of disability and cognitive function.ConclusionsThese results provide some support for a vascular aetiology of late-life depression. However, important risk factors for cerebrovascular disease such as hypertension and diabetes were not implicated, and the associations with lipid levels might still be explained by affective states earlier in life.

Download Full-text

Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2019.01.012 ◽

2019 ◽

Vol 111 ◽

pp. 30-35 ◽

Cited By ~ 12

Author(s):

Jingkai Wei ◽

Meiling Ying ◽

Liyang Xie ◽

Eeshwar K. Chandrasekar ◽

Haidong Lu ◽

...

Keyword(s):

Older Adults ◽

Cognitive Function ◽

National Health ◽

Late Life ◽

Nutrition Examination Survey ◽

Late Life Depression ◽

Health And Nutrition ◽

The U.S

Download Full-text

Vascular disease/risk and late-life depression in a Korean community population

The British Journal of Psychiatry ◽

10.1192/bjp.185.2.102 ◽

2004 ◽

Vol 185 (2) ◽

pp. 102-107 ◽

Cited By ~ 43

Author(s):

Jae-Min Kim ◽

Robert Stewart ◽

Il-Seon Shin ◽

Jin-Sang Yoon

Keyword(s):

Risk Factors ◽

Cognitive Function ◽

Vascular Disease ◽

Disease Risk ◽

Apoe Genotype ◽

Density Lipoprotein ◽

Late Life ◽

Late Life Depression ◽

Previous Stroke ◽

Community Population

BackgroundAssociations between vascular risk factors and late-life depression are controversial.AimsTo investigate the association between measures of vascular disease/ risk and depression and confounding and effect modification by APOE genotype and cognitive function.MethodIn a Korean community population aged 65+ (n=732), diagnosis of depression (Geriatric Mental State Schedule) and information on vascular status, disability, APOE genotype and cognitive function were obtained.ResultsPrevious stroke and lower high-density lipoprotein cholesterol level (but neither hypertension nor diabetes) were significantly associated with depression (independently of disability and cognitive function). These associations were stronger in participants with borderline cognitive impairment, although not to a significant extent.ConclusionsExcept for previous stroke and an atherogenic lipid profile, associations between depression and other common risk factors for cerebrovascular disease were not evident.

Download Full-text

Life-Course Exposure to Early Socioeconomic Environment, Education in Relation to Late-Life Cognitive Function Among Older Mexicans and Mexican Americans

Journal of Aging and Health ◽

10.1177/0898264311421524 ◽

2011 ◽

Vol 23 (7) ◽

pp. 1027-1049 ◽

Cited By ~ 23

Author(s):

Adina Zeki Al Hazzouri ◽

Mary N. Haan ◽

Sandro Galea ◽

Allison E. Aiello

Keyword(s):

Cognitive Function ◽

Elementary Education ◽

Life Course ◽

Cognitive Aging ◽

Mexican Americans ◽

Linear Regression Analysis ◽

Late Life ◽

The United States ◽

Multivariate Linear Regression Analysis ◽

Z Scores

Objectives: To examine the associations between life-course education and late-life cognitive function along with the modifying role of migration history. Method: The combined sample includes 1,789 participants from the Sacramento Area Latino Study on Aging and 5,253 participants from the Mexican Health and Aging Study. Aged 60+ at baseline, participants were classified as Mexican residents, Mexicans–return migrants, Mexicans–immigrants to the United States, and Mexicans–U.S. born. Cognitive function was measured using standardized z scores of a short-term verbal recall test. Multivariate linear regression analysis was conducted. Results: Participants’ z scores were higher among those whose mother had more than elementary education (β = 0.28, p < .05). Participant’s education mediated this association. For 5-year difference in education, the cognitive z score increased by 0.3 points for a U.S. born. Results were similar with father’s education. Discussion: Adult educational attainment mediates the effect of childhood socioeconomic status on late-life cognition. Migration plays a role in shaping cognitive aging.

Download Full-text

Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India

International Psychogeriatrics ◽

10.1017/s1041610221001186 ◽

2021 ◽

pp. 1-14

Author(s):

Murali Krishna ◽

Ghattu V. Krishnaveni ◽

Veena Sargur ◽

Kalyanaraman Kumaran ◽

Mohan Kumar ◽

...

Keyword(s):

Birth Weight ◽

Cognitive Function ◽

Brain Development ◽

Educational Level ◽

Early Life ◽

South India ◽

Late Life ◽

Positive Effects ◽

Cardiometabolic Disorders ◽

Size At Birth

ABSTRACT Objective: To examine if smaller size at birth, an indicator of growth restriction in utero, is associated with lower cognition in late life, and whether this may be mediated by impaired early life brain development and/or adverse cardiometabolic programming. Design: Longitudinal follow-up of a birth cohort. Setting: CSI Holdsworth Memorial Hospital (HMH), Mysore South India. Participants: 721 men and women (55–80 years) whose size at birth was recorded at HMH. Approximately 20 years earlier, a subset (n = 522) of them had assessments for cardiometabolic disorders in mid-life. Measurements: Standardized measurement of cognitive function, depression, sociodemographic, and lifestyle factors; blood tests and assessments for cardiometabolic disorders Results: Participants who were heavier at birth had higher composite cognitive scores (0.12 SD per SD birth weight [95% CI 0.05, 0.19] p = 0.001) in late life. Other lifecourse factors independently positively related to cognition were maternal educational level and participants’ own educational level, adult leg length, body mass index, and socioeconomic position, and negatively were diabetes in mid-life and current depression and stroke. The association of birth weight with cognition was independent cardiometabolic risk factors and was attenuated after adjustment for all lifecourse factors (0.08 SD per SD birth weight [95% CI −0.01, 0.18] p = 0.07). Conclusions: The findings are consistent with positive effects of early life environmental factors (better fetal growth, education, and childhood socioeconomic status) on brain development resulting in greater long-term cognitive function. The results do not support a pathway linking poorer fetal development with reduced late life cognitive function through cardiometabolic programming.

Download Full-text

A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive function

International Journal of Geriatric Psychiatry ◽

10.1002/gps.2031 ◽

2008 ◽

Vol 23 (11) ◽

pp. 1110-1113 ◽

Cited By ~ 21

Author(s):

Kristen Carreira ◽

Mark D. Miller ◽

Ellen Frank ◽

Patricia R. Houck ◽

Jennifer Q. Morse ◽

...

Keyword(s):

Cognitive Function ◽

Late Life ◽

Interpersonal Psychotherapy ◽

Late Life Depression ◽

Controlled Evaluation

Download Full-text

Duration of Poverty and Subsequent Cognitive Function and Decline Among Older Adults in China, 2005–2018

Neurology ◽

10.1212/wnl.0000000000012343 ◽

2021 ◽

pp. 10.1212/WNL.0000000000012343

Author(s):

Xuexin Yu ◽

Wei Zhang ◽

Lindsay C. Kobayashi

Keyword(s):

Older Adults ◽

Cognitive Function ◽

Late Life ◽

Tobit Regression ◽

Annual Household Income ◽

Middle Income ◽

Healthy Longevity ◽

Rate Of Decline ◽

Statistical Yearbook

Objective:To investigate the relationship between late-life duration of poverty exposure and cognitive function and decline among older adults in China.Methods:Data were from 3,209 participants aged ≥64 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Duration of poverty, defined according to urban and rural regional standards from the China Statistical Yearbook, was assessed based on annual household income from 2005-2011 (never in poverty; 1/3 of the period in poverty; ≥2/3 of the period in poverty). Cognitive function was measured by the Chinese Mini Mental State Exam (CMMSE) from 2011-2018. We used attrition-weighted, multivariable mixed-effects Tobit regression to examine the association of duration of poverty with cognitive function and rate of decline.Results:A total of 1,162 individuals (36.21%) were never in poverty over the period from 2005-2011, 1,172 (36.52%) were in poverty 1/3 of the period, and 875 (27.27%) were in poverty ≥2/3 of the period. A longer poverty duration was associated with lower subsequent CMMSE scores with a dose-response relationship (1/3 vs. never in poverty: β = -0.98; 95% CI: -1.61 to -0.35; ≥2/3 vs. never in poverty: β = -1.55; 95% CI: -2.29 to -0.81). However, a longer duration of poverty was associated with a slower rate of CMMSE score decline over time from 2011-2018.Conclusion:These findings provide valuable evidence on the role of cumulative late-life poverty in relation to cognitive health among older adults in a rapidly urbanizing and aging middle-income country. Our findings may support a compensation hypothesis for cognitive reserve in this setting.

Download Full-text