Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats

A toxicity study was made on Lepidium sativum L. seeds used in Saudi traditional medicine for the treatment of various ailments. Lepidium sativum L. seed fed to Wistar albino rats at 2% (w/w) was non-toxic, Ten percent (w/w) was toxic but not fatal and 50% (w/w) of the diet for 6 weeks was lethal and caused depression in growth rate and entero-hepato-nephrotoxicity. Organ lesions accompanied by anemia and leukopenia were correlated with alterations in serum AST and ALT activities and concentrations of total protein, cholesterol, urea, and other serum constituents.

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Sub-acute Toxicity Study and Toxicity Reversibility of Ayabirungarajakarpamin Wistar Albino Rats

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs/lpr.2021.11.4.p33-41 ◽

2021 ◽

Vol 11 (4) ◽

pp. 33-41

Author(s):

Varnakulendran Nagalingam ◽

Elango Veeriah

Keyword(s):

Acute Toxicity ◽

Toxicity Study ◽

Albino Rats ◽

Acute Toxicity Study ◽

Wistar Albino Rats

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Acute Toxicity Study and Determination of Median Lethal Dose of Catharanthus roseus in Wistar Albino Rats

Journal of Applied Sciences ◽

10.3923/jas.2019.217.222 ◽

2019 ◽

Vol 19 (3) ◽

pp. 217-222 ◽

Cited By ~ 1

Author(s):

M.G. Ajuru ◽

G. Ajuru ◽

F.W. Nmom ◽

C.W. Worlu ◽

P.G. Igoma

Keyword(s):

Acute Toxicity ◽

Catharanthus Roseus ◽

Lethal Dose ◽

Toxicity Study ◽

Albino Rats ◽

Median Lethal Dose ◽

Acute Toxicity Study ◽

Wistar Albino Rats

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Evaluation of Safety of Karnasphota (Cardiospermum halicacabum L.) Leaf through Acute Oral Toxicity Study and Repeated Dose: 28-day Oral Toxicity Study in Wistar Albino Rats

Journal of Drug Research in Ayurvedic Sciences ◽

10.5005/jp-journals-10059-0031 ◽

2018 ◽

Vol 3 (1) ◽

pp. 15-22

Author(s):

Sudesh N Gaidhani ◽

Kandiyoor R Surabhi ◽

Yalwar R Sanjayakumar ◽

Paravazhi Radhakrishnan ◽

Natarajan Thamizhselvam ◽

...

Keyword(s):

Toxicity Study ◽

Repeated Dose ◽

Albino Rats ◽

Acute Oral Toxicity ◽

Oral Toxicity ◽

Wistar Albino Rats

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ANTI ARTHRITIC ACTIVITY OF HERBO MINERAL SIDDHA PREPARATION ARUMUGA CHENDURAM AGAINST TYPE II COLLAGEN INDUCED ARTHRITIS IN EXPERIMENTAL RATS

International Journal of Ayurveda and Pharma Research ◽

10.47070/ijapr.v8i7.1493 ◽

2020 ◽

pp. 28-36

Author(s):

M. Ramamurthy ◽

V. Thanigavelan ◽

S. Elansekaran ◽

V. Srinivasan ◽

P. Shanmugapriya ◽

...

Keyword(s):

Acute Toxicity ◽

Type Ii Collagen ◽

Toxicity Study ◽

Albino Rats ◽

Type Ii ◽

Collagen Induced Arthritis ◽

Immune Disorder ◽

Animal Products ◽

Acute Toxicity Study ◽

Wistar Albino Rats

Siddha system of medicine is the eternal science of life. It is a system that has its extensive bonding with Dravidian culture, language and beliefs. The system of medicine mostly prevailed and prospered in the regions of Dravidian cultures by the great Siddhars. It’s unique as one only than other AYUSH traditional systems of medicine across India with its distinctive abundant usage of medicinal plants, metals, minerals and animal products. Siddhars used the steps of Alchemy to prepare various medicines from metallic and mineral origin for attainment elixir and various rare diseases. Siddha medicine is classified into 32 types of internal and external medicine each. Among the 32 types of internal medicine Chendhuram is a medicine shelf life of 75 years usually from herbo-mineral combinations. Arumuga Chendhuram (ARC) is a herbo-mineral formulation cited in Siddha literature ‘Siddha Vaithiya Thirattu’. ARC was orally administered at higher dose 2gm/kg to the Wistar Albino rats in acute toxicity study and during 28 days of repeated (sub acute) toxicity study, at daily doses of 12, 24 & 48mg/kg of body weight to the Wistar Albino rats. Type II collagen arthritis is another model for developing autoimmune arthritis. The immune pathogenesis mediated by T cell and B cell response to collagen. By this model, nearly 100% arthritis can be achieved. In our study, ARC after 42 days treatment reduced the arthritic swelling significantly and degree of inflammation evident to act against auto immune disorder.

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