Therapeutic potential of morin against liver fibrosis in rats: Modulation of oxidative stress, cytokine production and nuclear factor kappa B

2014 ◽  
Vol 37 (2) ◽  
pp. 662-671 ◽  
Author(s):  
Gehan H. Heeba ◽  
Magda E. Mahmoud
Keyword(s):  
Oxidative Stress ◽  
Liver Fibrosis ◽  
Nuclear Factor Kappa B ◽  
Cytokine Production ◽  
Therapeutic Potential ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Dihydromyricetin Prevents Inflammation and Oxidative Stress in Human Osteoarthritis Chondrocytes

2021 ◽  
Vol 20 (1) ◽  
pp. 207-212
Author(s):  
Pengbo Yao ◽  
Jinwei Ai
Keyword(s):  
Oxidative Stress ◽  
Nuclear Factor Kappa B ◽  
Therapeutic Potential ◽  
Cell Model ◽  
Cartilage Degradation ◽  
Cartilage Destruction ◽  
Interleukin 1Β ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Osteoarthritis is characterized by inflammation and joint cartilage degradation. Dihydromyricetin, a natural flavonoid in rattan tea, exhibits several pharmacological properties including antitumor, cardioprotection, antidiabetes, neuroprotection, hepatoprotection, and dermatoprotection. Herein, we have investigated in vitro the effects of dihydromyricetin on osteoarthritis progression using an interleukin-1β-induced cell model. Our data show that dihydromyricetin markedly improved the viability of interleukin-1β-treated chondrocytes. Furthermore, dihydromyricetin markedly downregulated the expression of nitric oxide, prostaglandin-E2, tumor necrosis factor-α, and interleukin-6, and ameliorated cartilage destruction in interleukin- 1β-treated chondrocytes, as well as inhibited the interleukin-1β-induced oxidative stress via the nuclear factor kappa B axis. In summary, our results demonstrate therapeutic potential of dihydromyricetin in osteoarthritis through modulation of the nuclear factor kappa B signaling pathway.

scholarly journals Brain angiotensin or nuclear factor kappa B blockade attenuates cytokines, oxidative stress and decreases sympathoexcitation in hypertension

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Yu‐Ming Kang ◽  
Ying Ma ◽  
Srinivas Sriramula ◽  
Jin‐Ping Zheng ◽  
Zhi‐Ming Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
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