Dihydromyricetin Prevents Inflammation and Oxidative Stress in Human Osteoarthritis Chondrocytes

Osteoarthritis is characterized by inflammation and joint cartilage degradation. Dihydromyricetin, a natural flavonoid in rattan tea, exhibits several pharmacological properties including antitumor, cardioprotection, antidiabetes, neuroprotection, hepatoprotection, and dermatoprotection. Herein, we have investigated in vitro the effects of dihydromyricetin on osteoarthritis progression using an interleukin-1β-induced cell model. Our data show that dihydromyricetin markedly improved the viability of interleukin-1β-treated chondrocytes. Furthermore, dihydromyricetin markedly downregulated the expression of nitric oxide, prostaglandin-E2, tumor necrosis factor-α, and interleukin-6, and ameliorated cartilage destruction in interleukin- 1β-treated chondrocytes, as well as inhibited the interleukin-1β-induced oxidative stress via the nuclear factor kappa B axis. In summary, our results demonstrate therapeutic potential of dihydromyricetin in osteoarthritis through modulation of the nuclear factor kappa B signaling pathway.

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Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

International Journal of Nanomedicine ◽

10.2147/ijn.s76114 ◽

2015 ◽

pp. 1463 ◽

Cited By ~ 105

Author(s):

Caixia Guo ◽

Yinye Xia ◽

Piye Niu ◽

Lizhen Jiang ◽

Junchao Duan ◽

...

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Silica Nanoparticles ◽

Nuclear Factor Kappa B ◽

Nuclear Factor ◽

Nrf2 Pathway ◽

Nuclear Factor Kappa

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Therapeutic potential of morin against liver fibrosis in rats: Modulation of oxidative stress, cytokine production and nuclear factor kappa B

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2014.01.026 ◽

2014 ◽

Vol 37 (2) ◽

pp. 662-671 ◽

Cited By ~ 28

Author(s):

Gehan H. Heeba ◽

Magda E. Mahmoud

Keyword(s):

Oxidative Stress ◽

Liver Fibrosis ◽

Nuclear Factor Kappa B ◽

Cytokine Production ◽

Therapeutic Potential ◽

Nuclear Factor ◽

Nuclear Factor Kappa

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L-Tetrahydropalmatine Inhibits the Progression of Glioblastoma Tumor by Suppressing the Extracellular-Signal-Regulated Kinase/Nuclear Factor-Kappa B Signaling Pathway

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.19:164-171 ◽

2020 ◽

Vol 19 (2) ◽

pp. 164-171

Author(s):

Feng Xue ◽

Tingting Chen

Keyword(s):

Glioblastoma Multiforme ◽

Nuclear Factor Kappa B ◽

Matrix Metalloproteinase 2 ◽

Nuclear Factor ◽

Nuclear Factor Kappa ◽

Extracellular Signal ◽

Apoptosis Protein ◽

Endothelial Growth Factor

Glioblastoma multiforme is the most common malignancy of central nervous system. Herein we have evaluated the effect of L-tetrahydropalmatine, an isoquinoline alkaloid, on the tumor growth both in vivo and in vitro using C6 glioblastoma multiforme cells and BALB/c mice injected subcutaneously with C6/luc2 cells. The results of these studies show that L-tetrahydropalmatine exhibited cytotoxic effect on C6 glioblastoma multiforme cells, suppressed nuclear factor-kappa B activity, suppressed the levels of tumor-linked proteins such as matrix metalloproteinase-2/9, Cyclin-D1, vascular endothelial growth factor, and X-linked inhibitor of apoptosis protein via ERK/nuclear factor-kappa B cascade. Further, L-tetrahydropalmatine inhibited the cell migration and invasion properties of C6 cells, and also suppressed the tumor weight and volume in mice. Immunohistochemical staining of tumor tissues suggested that L-tetrahydropalmatine inhibited the extracellular-signal-regulated kinase/nuclear factor-kappa B cascade and suppressed the levels of Cyclin-D1; matrix metalloproteinase-2/9; X-linked inhibitor of apoptosis protein; and vascular endothelial growth factor, and also the progression and growth of glioblastoma multiforme in mice. In summary, L-tetrahydropalmatine inhibits the ERK/nuclear factor-kappa B cascade, decreases the tumor volume, and inhibits the proteins responsible for tumor growth both in vivo and in vitro.

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