Background:
Fungal infections are opportunistic infections that become a serious problem to human health.
Objective:
Considering the antifungal potential of triazole nucleus, the study was carried out with the objective to synthesize
some novel triazole derivatives with antifungal potential.
Method:
1,2,4-triazole derivatives were synthesized via a two step reaction (reported earlier). The first step involves reaction of substituted benzoic acid with thiocarbohydrazide to form 4-amino-3-(substituted phenyl)-5-mercapto-1, 2, 4-triazole
derivatives (1a-1k) while in second step, synthesized compounds (1a-1k) were then subsequently treated with substituted
acetophenone to yield substituted (4-methoxyphenyl-7H-[1, 2, 4] triazolo [3, 4-b][1,3,4] thiadiazine derivatives (2a-2k). All
synthesized compounds were characterized by IR, 1H NMR, and Mass spectral data analysis and were screened for their antifungal properties against different fungal strains i.e. Candida tropicalis (ATCC-13803, ATCC-20913), Candida albicans
(ATCC-60193), Candida inconspicua (ATCC-16783) and Candida glabrata (ATCC-90030, ATCC-2001).
Results:
Compound 2d displayed better percentage inhibition (26.29%, 24.81%) than fluconazole (24.44%, 22.96%) against
ATCC-16783, ATCC-2001 fungal strains respectively at 100µg/ml. Compound 2f also displayed better percentage inhibition (28.51%) against ATCC-90030 as compared to fluconazone (27.4%) at 200 µg/ml. Similarly, compounds 2e and 2j also
exhibited better antifungal properties than fluconazole at 200µg/ml. Compound 2e was found most potent against ATCC13803 (30.37%) and ATCC-90030 (30.37%) fungal strains as compared to fluconazole (28.14%, 27.4%) at 200 µg/ml respectively whereas compound 2j exhibited better antifungal activity (28.51%) against ATCC-60193 than fluconazole
(27.7%) at 200 µg/ml.
Conclusion:
The results were in accordance with our assertions for triazole derivatives, as all compounds displayed moderate to good antifungal activity.
Sustainable degradation of pharmaceutical waste using different fungal strains: Enzyme induction, kinetics and isotherm studies
