Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y1 receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression

2007 ◽  
Vol 17 (4) ◽  
pp. 298-308 ◽  
Author(s):  
Patricia A. Jiménez-Vasquez ◽  
Zaida Diaz-Cabiale ◽  
Laura Caberlotto ◽  
Inmaculada Bellido ◽  
David Overstreet ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Rat Model ◽  
Receptor Gene ◽  
Gene Expressions ◽  
Y1 Receptor ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression

2010 ◽  
Vol 34 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Olga Kotsovolou ◽  
Magnus Ingelman-Sundberg ◽  
Matti A. Lang ◽  
Marios Marselos ◽  
David H. Overstreet ◽  
...  
Keyword(s):  
Rat Model ◽  
Hepatic Drug ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Monitoring of antisense effects of oligonucleotides targeted to the neuropeptide Y Y1 receptor gene

1997 ◽  
Vol 330 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Jörg Hänze ◽  
Stefan Worgall ◽  
Wolfgang Rascher
Keyword(s):  
Neuropeptide Y ◽  
Receptor Gene ◽  
Y1 Receptor

scholarly journals Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: Effect of ketamine

Synapse ◽  
2016 ◽  
Vol 71 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Kristian Gaarn Du Jardin ◽  
Heidi Kaastrup Müller ◽  
Connie Sanchez ◽  
Gregers Wegener ◽  
Betina Elfving
Keyword(s):  
Gene Expression ◽  
Rat Model ◽  
Glutamatergic Neurotransmission ◽  
Depression Effect ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression

2015 ◽  
Vol 40 (11) ◽  
pp. 2293-2303
Author(s):  
Helene Blanchard ◽  
Lisa Chang ◽  
Amir H. Rezvani ◽  
Stanley I. Rapoport ◽  
Ameer Y. Taha
Keyword(s):  
Arachidonic Acid ◽  
Rat Model ◽  
Acid Incorporation ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Sirtuins and Neuropeptide y downregulation in Flinders Sensitive Line Rat Model of Depression

2021 ◽  
pp. 1-19
Author(s):  
Miranda Stiernborg ◽  
Paschalis Efstathopoulos ◽  
Andreas Lennartsson ◽  
Catharina Lavebratt ◽  
Aleksander A. Mathé
Keyword(s):  
Rat Model ◽  
Histone Deacetylases ◽  
Sirtuin 1 ◽  
Model Organisms ◽  
Age Related ◽  
Age Dependent ◽  
Sensitive Line ◽  
And Control ◽  
Temporal Trajectory ◽  
Flinders Sensitive Line

Abstract Objective: Since the NAD+-dependent histone deacetylases sirtuin-1 (SIRT1) and sirtuin-2 (SIRT2) are critically involved in epigenetics, endocrinology and immunology and affect the longevity in model organisms, we investigated their expression in brains of 3 month old and 14-15 month old rat model of depression Flinders Sensitive Line (FSL) and control Flinders Resistant Line (FRL) rats. In view of the dysregulated NPY system in depression we also studied NPY in young and old FSL to explore the temporal trajectory of depressive-like-ageing interaction. Methods: Sirt1, Sirt2 and Npy mRNA were determined using qRT-PCR in prefrontal cortex (PFC) from young and old FSL and FRL, and in hippocampi from young FSL and FRL. Results: PFC. Sirt1 expression was decreased in FSL (p=0.001). An interaction between age and genotype was found (p=0.032); young FSL had lower Sirt1 with respect to both age (p=0.026) and genotype (p=0.001). Sirt2 was lower in FSL (p=0.003). Npy mRNA was downregulated in FSL (p=0.001) but did not differ between the young and old rat groups. Hippocampus.Sirt1 was reduced in young FSL compared to young FRL (p=0.005). There was no difference in Sirt2 between FSL and FRL. Npy levels were decreased in hippocampus of young FSL compared to young FRL (p=0.003). Effects of ageing could not be investigated due to loss of samples. Conclusions: i. This is the first demonstration that SIRT1 and SIRT2 are changed in brain of FSL, a rat model of depression ; ii. The changes are age dependent; iii. Sirtuins are potential targets for treatment of age-related neurodegenerative diseases.

scholarly journals Altered fecal microbiota composition in the Flinders sensitive line rat model of depression

2018 ◽  
Vol 236 (5) ◽  
pp. 1445-1457 ◽  
Author(s):  
Sandra Tillmann ◽  
Anders Abildgaard ◽  
Gudrun Winther ◽  
Gregers Wegener
Keyword(s):  
Rat Model ◽  
Fecal Microbiota ◽  
Microbiota Composition ◽  
Sensitive Line ◽  
Flinders Sensitive Line
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