P.424 Prolonged use of central nervous system depressant medication and cognitive function are associated with experienced pain among older adults

2020 ◽  
Vol 40 ◽  
pp. S239-S240
Author(s):  
M.T. Bjelkarøy ◽  
S. Cheng ◽  
T. Siddiqui ◽  
R. Grambaite ◽  
E.S. Kristoffersen ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Function ◽  
Experienced Pain ◽  
Central Nervous System Depressant

PENENTUAN NILAI PARAMETER LIPOFILITAS SENYAWA 4-KLOROBENZOILTIOUREA DAN UJI POTENSIASI TERHADAP TIOPENTAL PADA MENCIT PUTIH (Mus musculus)

2019 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Dini Kesuma
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electronic Properties ◽  
Mus Musculus ◽  
Log P ◽  
P Value ◽  
Lead Compounds ◽  
Significant Difference ◽  
Central Nervous System Depressant ◽  
The Central Nervous System

Synthesis of the 4-chlorobenzoylthiourea compound was carried out by acylating thiourea with 4-chlorobenzoyl chloride. The 4-chlorobenzoylthiourea compound  will increase the lipophilic and the electronic properties other than the lead compounds of benzoylthiourea in order to, by expectation, raise the central nervous system depressant as well. The lipophilic would affect the ability of the compounds in penetrating biological membranes, which is highly dependent on the solubility of the drug within lipid/water. Log P is the most common method used in determining the parameter value. This experiment was to mix two dissolvents (octanol and water) which are immissible. The both levels of the compounds were carefully observed by a spectrophotometer UV-Vis. From the test, the result of log P value of the 4-chlorobenzoylthiourea compound was 2.32, while the theoretical log P value of the compounds, by using the π Hansch-Fujita method is 1.62 and the f Rekker-Mannhold method is 2.225. Consequently, the result of the test shows that there is a significant difference between the progress experiment and both theoretical log P methods. Moreover, in the test of the central nervous system depressant through the potentiation test to thiopental using mice indicates that the 4-chlorobenzoylthiourea compound have potentiation effects to thiopental compared to the lead compounds of benzoylthiourea.

Central nervous system active compounds. VI. Reissert compounds as precursors of 1-(3-phthalidy1)isoquinolines

1981 ◽  
Vol 34 (1) ◽  
pp. 151 ◽  
Author(s):  
TV Hung ◽  
BA Mooney ◽  
RH Prager ◽  
AD Ward
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Phase Transfer ◽  
Active Compounds ◽  
Central Nervous System Depressant ◽  
Reissert Compounds

The reactions of isoquinoline and phthalazine Reissert compounds with phthalaldehydic acids and their derivatives have been investigated as a means of synthesizing 1-(3-phthalidyl)isoquinolines. Of a variety of conditions tried those involving phase transfer were found, in general, to be the most suitable. The products, which are analogues of the convulsant alkaloid bicuculline, showed weak central nervous system depressant activity.

scholarly journals Sleep-Disordered Breathing Is Associated With Impaired Odor Identification in Older U.S. Adults

2020 ◽  
Author(s):  
Jesse K Siegel ◽  
Xiandao Yuan ◽  
Kristen E Wroblewski ◽  
Martha K McClintock ◽  
Jayant M Pinto
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Sleep Apnea ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Sleep Disordered Breathing ◽  
Odor Identification ◽  
Odor Sensitivity ◽  
Disordered Breathing

Abstract Background Sleep-disordered breathing (SDB) is a common, underdiagnosed condition in older adults with major health consequences, including disrupted central nervous system functioning. Whether SDB may affect sensory function is unclear. We sought to address this question by comparing 2 forms of olfactory testing which measure peripheral and central olfactory processing. Methods We assessed SDB (survey-reported snoring frequency, nighttime apneic events, or diagnosis of sleep apnea) in the National Social Life, Health, and Aging Project, a nationally representative sample of older U.S. adults. Odor sensitivity (peripheral) and odor identification (central) were assessed with validated instruments. Logistic regression was used to test the relationship between SDB and olfaction, accounting for relevant covariates, including demographics, cognition, and comorbidity. Results Twenty-nine percent of older U.S. adults reported symptoms of SDB (apneic events or nightly snoring). Of these, only 32% had been diagnosed with sleep apnea. Older adults with SDB (those who reported symptoms or have been diagnosed with sleep apnea) were significantly more likely to have impaired odor identification (odds ratio 2.13, 95% confidence interval 1.19–3.83, p = .012) in analyses that accounted for age, gender, race/ethnicity, education, cognition, comorbidities (including depression), and body mass index. Presence of SDB was not associated with impaired odor sensitivity (odds ratio 1.03, 95% confidence interval 0.75–1.43, p = .84). Conclusion SDB is highly prevalent but underdiagnosed in older U.S. adults and is associated with impaired odor identification but not odor sensitivity. These data support the concept that SDB affects pathways in the central nervous system which involve chemosensory processing.

EVALUATING THE ASSOCIATION BETWEEN CENTRAL NERVOUS SYSTEM (CNS)-ACTIVE MEDICATION USE AND FALL-RELATED INJURIES IN OLDER ADULTS WITH DEMENTIA

2017 ◽  
Vol 13 (7) ◽  
pp. P1564-P1565
Author(s):  
Laura A. Hart ◽  
Zachary Marcum ◽  
Shelly L. Gray ◽  
Rod L. Walker ◽  
Paul K. Crane ◽  
...  
Keyword(s):  
Older Adults ◽  
Central Nervous System ◽  
Nervous System ◽  
Medication Use ◽  
Active Medication

5-(2-Aminoethyl)-2-oxazolidinones with central nervous system depressant and antiinflammatory activity

1973 ◽  
Vol 16 (10) ◽  
pp. 1129-1132 ◽  
Author(s):  
William J. Welstead ◽  
Grover C. Helsley ◽  
C. Roy Taylor ◽  
Lennox B. Turnbull ◽  
John P. Da Vanzo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antiinflammatory Activity ◽  
Central Nervous System Depressant

scholarly journals Lavandulae aetheroleum Oil: A Review on Phytochemical Screening, Medicinal Applications, and Pharmacological Effects

2020 ◽  
Vol 11 (3) ◽  
pp. 9836-9847
Keyword(s):  
Central Nervous System ◽  
Clinical Pharmacology ◽  
Nervous System ◽  
Chemical Constituents ◽  
Cardiovascular Effects ◽  
Pharmacological Effects ◽  
Lavandula Angustifolia ◽  
Experimental Pharmacology ◽  
Central Nervous System Depressant ◽  
Anti Inflammatory

Lavandulae aetheroleum, the oil, was obtained by vapor condensation from the flower of Lavandula angustifolia Mill. or Lavandula intermedia Loisel (Lamiaceae) plant. Other names of Lavandulae aetheroleum oil are Al birri, common or English lavender. The Lavandula angustifolia Mill. or Lavandula intermedia Loisel plant is spreading in the Mediterranean, southern Europe, Bulgaria, Russia, and USA. The Lavandula angustifolia Mill. or Lavandula intermedia Loisel plant, is an odor shrub with 1-2 m in height. The oil is a clear, colorless, or pale yellow. The gas chromatography studies reported the following percentage of the major chemical constituents in the oil: linalyl acetate (25-46%), linalool (20-45%), terpinen-4-ol (1.2-6.0%), lavendulyl acetate (> 1.0%), 1,8-cineole (1,8-cineol, cineol, cineole, eucalyptol) (< 2.5%), 3-octanone (< 2.5%), camphor (< 1.2%), limonene (< 1.0%), and α-terpineol (< 2.0%). Medicinal applications of the oil include the treatment of restlessness, anxiety, cardiovascular disorders, insomnia, and gastrointestinal disorders, burns, diarrhea, headache, sore throats, and wounds. Pharmacological effects include experimental and clinical pharmacology. Experimental pharmacology includes anesthetic, anticonvulsant, sedative, anti-inflammatory, antimicrobial, antispasmodic, antispasmodic, central nervous system depressant effects. Clinical pharmacology includes anxiolytic, analgesic, and cardiovascular effects. The oil dose by inhalation = 0.06-0.2 ml/ 3 times/day while oil dose internally = 1-4 drops approximately 20-80 mg on a sugar cube per day. In conclusion, Lavandulae aetheroleum oil had an anesthetic, anticonvulsant, sedative, anti-inflammatory, antimicrobial, antispasmodic, antispasmodic, central nervous system depressant, anxiolytic, analgesic, and cardiovascular effects.

Yoga Therapy on Cognitive Function in Neurodevelopmental Disorders

2020 ◽  
pp. 143-160
Author(s):  
Artchoudane Soccalingam ◽  
Meena Ramanathan ◽  
Ananda Balayogi Bhavanani
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Function ◽  
Neurodevelopmental Disorders ◽  
Body Awareness ◽  
Yoga Therapy ◽  
Breath Awareness ◽  
Major Factors ◽  
Sensory Processes ◽  
And Behavior

Neurodevelopmental disorders (NDDs) are birth imperfections that cause dysfunction in cognitive and sensory processes and impairment in motor function, communication, and behavior. The major factors responsible for increasing incidence of NDDs are genetic, psychosocial, and excessive use of drugs. Yoga alleviates neurological problems and NDDs. Asana is a physical movement with breath awareness that facilitates the development of body awareness, concentration, and memory and provides vital energy for children with neurodevelopmental disability. Yoga therapy improves sensory coordination and motor imitations that enable persons with cognitive disabilities to make meaningful response by the integration of senses and functions of central nervous system.

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