Obstetric complications in patients with schizophrenia and their unaffected siblings

2005 ◽  
Vol 20 (1) ◽  
pp. 28-34 ◽  
Author(s):  
M. Walshe ◽  
C. McDonald ◽  
M. Taylor ◽  
J. Zhao ◽  
P. Sham ◽  
...  
Keyword(s):  
Risk Factor ◽  
Family History ◽  
Genetic Susceptibility ◽  
Environmental Risk ◽  
Obstetric Complications ◽  
Control Group ◽  
Environmental Risk Factor ◽  
Schizophrenic Patients ◽  
History Of ◽  
Elevated Rate

AbstractObjectiveWe sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia.MethodsThe presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group.ResultsOCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings.ConclusionOur data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes.

Schizophrenics with a family history of bipolar disorder. Possible involvement of obstetric complications

1993 ◽  
Vol 8 (4) ◽  
pp. 223-226
Author(s):  
H Verdoux ◽  
M Bourgeois
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Case Reports ◽  
Obstetric Complications ◽  
Schizophrenic Patients ◽  
History Of ◽  
The Continuum

SummaryThe case reports of two DSM III-R schizophrenic patients with a family history of bipolar disorder are presented. The two patients had a history of severe obstetric complications (OCs). These cases are discussed in the light of neurodevelopmental theories of schizophrenia and in the continuum view of psychosis.

scholarly journals Association of family history of schizophrenia and history of obstetric complications at birth: relationship with age at onset and psychopathology dimensions in a Nigerian cohort

2020 ◽  
Vol 20 (2) ◽  
pp. 697-708
Author(s):  
Justus Uchenna Onu ◽  
Jude Uzoma Ohaeri
Keyword(s):  
Risk Factor ◽  
Family History ◽  
Independent Risk Factor ◽  
Age At Onset ◽  
Obstetric Complications ◽  
Symptom Dimensions ◽  
Clinical Phenotypes ◽  
The Family ◽  
Psychopathological Symptom ◽  
History Of

Background: The nature of the association between obstetric complications (OCs) at birth and the genetic aetiology of schizo- phrenia remains unclear, as some authors suggest that it is an independent risk factor while others support either interactionism or an epiphenomenon perspective. Objective: To examine the association of family history of schizophrenia (FHS) with history of OCs, with a view to assessing whether this relationship moderates clinical phenotypes such as symptom dimensions and age at onset of illness. Methods: This study examined OCs among schizophrenia probands using the Obstetric Complications Scale. An inquiry into family history was performed using the Family history method. Psychopathological symptom dimensions were assessed using standard scales. Data were analyzed to examine the interaction of FHS and history of OCs with age at onset and symptom dimensions, using ANCOVA. Results: FHS was significantly associated with the disorganized symptoms dimension (p=0.03). History of OCs was significant- ly associated with earlier age at onset (p=0.007). However, in ANCOVA, the effect of the interaction between FHS and history of OCs was not significant for age at onset and symptom dimensions (P = 0.059). Conclusion: FHS was significantly associated with disorganization syndrome, and OCs was significantly associated with age at onset. Keywords: Family history; schizophrenia; obstetric complications; symptom dimensions; age at onset.

Prevalence of Familiality, Obstetric Complications, and Structural Brain Damage in Schizophrenic Patients

1988 ◽  
Vol 153 (2) ◽  
pp. 191-197 ◽  
Author(s):  
V. L. Nimgaonkar ◽  
S. Wessely ◽  
R. M. Murray
Keyword(s):  
Family History ◽  
Brain Damage ◽  
Obstetric Complications ◽  
Ventricular Enlargement ◽  
Clinical Variables ◽  
Structural Brain Damage ◽  
Schizophrenic Patients ◽  
History Of ◽  
Structural Brain

Schizophrenic in-patients with and without a family history were identified prospectively. The two groups did not differ with respect to clinical variables, ventricular enlargement, prevalence of cortical sulcal widening, or a history of obstetric complications, even when a variety of definitions of familiality were used.

Childhood parental loss and alcoholism in women: a causal analysis using a twin-family design

1996 ◽  
Vol 26 (1) ◽  
pp. 79-95 ◽  
Author(s):  
K. S. Kendler ◽  
M. C. Neale ◽  
C. A. Prescott ◽  
R. C. Kessler ◽  
A. C. Heath ◽  
...  
Keyword(s):  
Risk Factor ◽  
Environmental Risk ◽  
Structural Equation ◽  
Significant Proportion ◽  
Parental Loss ◽  
Environmental Risk Factor ◽  
History Of ◽  
Genetic Mechanisms ◽  
Maternal Alcoholism

SynopsisChildhood parental loss may be an important risk factor for psychiatric illness in adulthood. While this association has been carefully examined for depression, little is known about the role of parental loss in predisposing to alcoholism. We examined an epidemiological sample of female twin pairs with the same history of continuity or disruption in parent–child relationships (N = 1018 pairs; mean age 30 years), using a range of definitions of alcoholism. Childhood parental loss through separation, but not death, substantially increased the risk in adulthood for all definitions of alcoholism. Furthermore, both paternal and maternal alcoholism substantially increased the probability of parental separation from their children. Proposing a structural equation twin-family model that incorporates childhood parental loss as a specified environmental risk factor, we examined how much of the association between childhood parental loss and alcoholism was causal (i.e. mediated by environmental factors) v. non-causal (mediated by genetic factors, with parental loss serving as an index of parental genetic susceptibility to alcoholism). Both the causal and non-causal paths were significant for all definitions of alcoholism. However, the causal–environmental pathway consistently accounted for most of the association. While a significant proportion of the association is due to non-causal genetic mechanisms, childhood parental loss (or the familial discord that precedes or follows it) is probably a direct and significant environmental risk factor for the development of alcoholism in women.

scholarly journals Prolonged Methamphetamine-Induced Psychosis: Difference With Schizophrenia

2019 ◽  
Author(s):  
Hamid Reza Ahmadkhaniha ◽  
Kaveh Alavi ◽  
Fatemeh Hadi
Keyword(s):  
Family History ◽  
Obstetric Complications ◽  
Medical Sciences ◽  
Neurological Soft Signs ◽  
Demographic Questionnaire ◽  
Significant Difference ◽  
Other Substances ◽  
Schizophrenic Patients ◽  
History Of ◽  
Close Relatives

The main objective of the present study was to compare the distribution of underlying factors such as neurological soft signs, obstetric complications, and family history of psychiatric disorders between two groups of schizophrenic patients and patients with prolonged methamphetamine-induced psychosis. In a case-control study, 30 patients with prolonged methamphetamine-induced psychosis and 30 patients with schizophrenia were selected. Data were collected through a demographic questionnaire, the Buchanan and Heinrichs’ Neurological Evaluation Scale (NES), the Lewis-Murray’s Obstetric Complications Scale (LMOCS), and the Weissman’s Family History Screen (FHS). Mean scores of the neurological soft signs (±SD) in the two groups of schizophrenic patients and patients with prolonged methamphetamine-induced psychosis were 15.7±8.7 and 11.7±6.2, respectively (P=0.040), and a significant difference was observed in the sensory integration between the two groups (P=0.022). Obstetric complications revealed similar distributions in the two groups. Patients with prolonged methamphetamine-induced psychosis reported higher prevalence of alcohol and other substances use disorders (P=0.003 and P=0.001, respectively) in their close relatives; however, the distributions of other disorders were not statistically different between the two groups’ close relatives. Similarities and differences in certain aspects were observed between the two groups, suggesting susceptibility for psychosis in patients with prolonged methamphetamine-induced psychosis; yet we found diversities that distinguish the two disorders. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(4):235-243

Personal melanoma risk awareness versus intrinsic risk.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 9069-9069
Author(s):  
Caroline Robert ◽  
Céleste Lebbé ◽  
Sevrine Ricard ◽  
Philippe Saiag ◽  
Florent Grange ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Family History ◽  
Sun Exposure ◽  
Risk Level ◽  
Control Group ◽  
Melanoma Risk ◽  
Protection Measures ◽  
Frequent Use ◽  
History Of

9069 Background: Intrinsic risk factors for melanoma include personal and family history of the condition, a high number of naevi and a light skin phototype (I or II). The objective of this study was to evaluate the correlation between personal awareness of melanoma risk and objective risk factors and to analyze the elements associated with under-or over-evaluation of the actual risk. Methods: EDIFICE melanoma, a nationwide French observational survey, was conducted through phone interviews on a representative sample of 1502 subjects aged ≥ 18 using typical quotas. The survey took place from 28th Sept 2011 to 20th Oct 2011. Results: 393 subjects (26%) had at least one melanoma risk factor: personal: 1%; family history: 11%; high number of naevi: 8% and phototype I-II: 11%. 1109 (74%) had no risk factor. 1029 (73%) had a correct perception of their risk level, 135 (10%) overestimated their risk and 241 (17%) underestimated it. Compared to the control group (correct perception), the population overestimating the melanoma risk is characterised by a higher percentage of individuals living alone (32% vs. 24%, p<0.05), socio-professional category + (38% vs. 28%, p<0.01) and greater alcohol consumption (45% vs. 34%, p<0.02). They are also more likely to expose themselves to the sun (89% vs. 78%, p<0.004) and less likely to use sunscreen protection (58% vs. 44%, p<0.003). A greater proportion of them participates in melanoma screening programmes (21% vs. 14%, p<0.04). The population that underestimates the risk is characterised by lower educational attainment (11% vs. 7%, p<0.05), greater use of high SPF sunscreen (41% vs. 29%, p<0.0004) and a more frequent use of UV sunbeds (9% vs. 6%, p<0.06). Conclusions: Overall, the French have a fair perception of their personal likelihood of developing melanoma. Interestingly, subjects overestimating their intrinsic risk do not behave appropriately with respect to sun protection measures (more sun exposure and less sunscreen protection). On the other hand, subjects underestimating their risk use UV sunbeds more extensively.

The Nithsdale Schizophrenia Surveys X: Obstetric Complications, Family History and Abnormal Movements

1992 ◽  
Vol 160 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Robin G. McCreadie ◽  
David J. Hall ◽  
Ian J. Berry ◽  
Lesley J. Robertson ◽  
James I. Ewing ◽  
...  
Keyword(s):  
Family History ◽  
Tardive Dyskinesia ◽  
Psychiatric Illness ◽  
Obstetric Complications ◽  
Degree Relative ◽  
Drug Induced ◽  
Abnormal Movements ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
History Of

Obstetric histories of 54 schizophrenic patients and 114 siblings were obtained from their mothers and scored using the Obstetric Complications Scale. There was no statistically significant difference in the proportion of schizophrenic patients (35%) and siblings (29%) who had at least one definite obstetric complication. There was no evidence that schizophrenic patients with a history of obstetric complications were less likely to have a first-degree relative with a history of psychiatric illness leading to in-patient care. Schizophrenic patients with a history of obstetric complications were more likely to have drug-induced Parkinsonism. There was a trend for tardive dyskinesia to be more common in those schizophrenic patients with no obstetric complications but a family history of schizophrenia.

scholarly journals The Nithsdale Schizophrenia Surveys

1994 ◽  
Vol 165 (3) ◽  
pp. 340-346 ◽  
Author(s):  
R. G. Mccreadie ◽  
M. A. Connolly ◽  
D. J. Williamson ◽  
R. W. B. Athawes ◽  
D. Tilak-Singh
Keyword(s):  
Family History ◽  
Personality Traits ◽  
Social Adjustment ◽  
Obstetric Complications ◽  
Childhood And Adolescence ◽  
Schizotypal Personality ◽  
Clinical Correlates ◽  
Syndrome Scale ◽  
Schizophrenic Patients ◽  
History Of

BackgroundThe aim was to examine in a population of schizophrenic patients the clinical correlates of ‘neurodevelopmental’ schizophrenia and their relationship to putative aetiological factors.MethodPremorbid social adjustment, premorbid schizoid and schizotypal personality traits, and the obstetric history of 40 schizophrenic patients and their 102 sibs were assessed through interviews with their mothers. Patients' premorbid level of intelligence was assessed by the National Adult Reading Test and current symptoms by the Positive and Negative Syndrome Scale and the Subjective Deficit Syndrome Scale.ResultsPatients had more schizoid and schizotypal traits than their sibs. They showed a deterioration in social adjustment between childhood and adolescence; sibs' social adjustment improved. There were statistically significant associations between current negative schizophrenic symptoms, premorbid deterioration in social adjustment, and schizoid and schizotypal personality traits, and between an early age of onset of illness and the same premorbid assessments. There was no evidence that patients with a family history of severe mental illness leading to hospitalisation, or a history of definite obstetric complications, had poorer premorbid functioning or more severe current symptoms.ConclusionsWe have confirmed clinical correlates of ‘neurodevelopmental’ schizophrenia but found no association between these and obstetric complications or a family history of severe mental disorder.

History of obstetric complications, family history, and CT scan findings in schizophrenic patients

1990 ◽  
Vol 3 (5-6) ◽  
pp. 311-314 ◽  
Author(s):  
Ravinder Reddy ◽  
Sukdeb Mukherjee ◽  
David B. Schnur ◽  
James Chin ◽  
Gustav Degreef
Keyword(s):  
Family History ◽  
Ct Scan ◽  
Obstetric Complications ◽  
Schizophrenic Patients ◽  
History Of

scholarly journals Association of EAAT1 and EAAT2 Genes Polymorphism With Schizophrenia in Chinese Han Population

2021 ◽  
Author(s):  
Lina Wang ◽  
Tantan Ma ◽  
Dongdong Qiao ◽  
Kaiyan Cui ◽  
Xiaojiao Bi ◽  
...  
Keyword(s):  
Family History ◽  
Verbal Learning ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Demographic Questionnaire ◽  
Syndrome Scale ◽  
Schizophrenic Patients ◽  
History Of

Abstract Background: Previous studies have linked schizophrenia to EAAT1 and EAAT2 genes. The aim of this study was to investigate the relationship between polymorphism of these two genes and schizophrenia in Chinese Han population. Methods: A total of 233 schizophrenic patients and 342 healthy controls were enrolled. Six SNPs including rs2269272、rs2731880、rs12360706、rs3088168、rs12294045、rs10836387 were genotyped by SNaPshot. Clinical features were collected using a general demographic questionnaire. Symptoms were measured by the Positive and Negative Syndrome Scale (PANSS), and cognitive function was assessed by Matrics Consensus Cognitive Battery (MCCB). Results: The allele frequency of EAAT1 rs2731880 was significantly different between patients and controls (c2=4.205, R=0.040). The allele and genotype frequency of EAAT2 rs12294045 were significantly different between case and control group (allele:c2 = 8.144，R = 0.004; genotype: c2 = 8.054, R = 0.02). Patients with family history of psychosis were more likely to have the CT genotype of rs12294045 than patients without family history of psychosis，while patients with CT genotype of rs12294045 had significantly lower scores of verbal learning and working memory.Conclusions: The polymorphism of EAAT1 and EAAT2 genes in Chinese Han population may be associated with schizophrenia. The CT genotype of EAAT2 rs12294045 may be one of the risk factors for verbal learning memory and working operational memory dysfunction in patients.

Sign in / Sign up

Export Citation Format

Share Document