Affective disorders, psychosis and lipid levels: Is there a connection? Linking psychopathology, clinical exams and neurobiology

2017 ◽  
Vol 41 (S1) ◽  
pp. S765-S765
Author(s):  
M. Nascimento ◽  
M. Lázaro ◽  
J. Reis ◽  
G. Pereira ◽  
F. Bacelar ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Affective Disorders ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Depressive Mood ◽  
Serum Concentrations ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Psychotic Features ◽  
The Relationship

IntroductionPublished research regarding the relationship between lipid levels in affective disorders has been contradictory. Additionally, most studies correlating psychosis to lipid serum concentrations only concern schizophrenic patients.ObjectiveTo access the relationship between serum lipid levels with the diagnosis and pathophysiology of affective disorders.MethodsDiagnostic data (ICD–10: F31–32), including mood and psychotic features, were prospectively collected for all patients admitted at the affective disorder ward at Centro Hospitalar Psiquiátrico de Lisboa (Portugal), during the third trimester of 2016. Serum concentrations of triglycerides and total/HDL/LDL cholesterol were evaluated using standard laboratory tests. Statistical analysis was performed for possible correlations between serum lipid levels and:– different stages of bipolar disorder (BD);– elevated versus depressive mood (unipolar and bipolar);– depressive mood (BD versus non-BD);– psychotic features.ResultsSixty-three patients admitted were enrolled in this study: 47 presented with BD (32 manic, 10 depressives and 5 mixed episodes) and 16 presented depressive disorders. Statistical analysis (R software) revealed that depressed bipolar patients had significantly higher triglyceride (P = 0.026), total and LDL cholesterol (P = 0.525) levels than other states; mixed episodes presented higher HDL levels (P = 0.542). Although not significant, manic patients’ HDL levels were consistently elevated compared to depressive ones, whom presented with lower values overall. Finally, when adjusted for age, psychotic patients showed lower levels of total (P = 0.031) and LDL cholesterol (P = 0.052) compared to non-psychotic patients.ConclusionsThere is a potential link between serum lipid levels and diagnosis/psychopathology of affective disorders. Further research is needed to characterize its pathophysiologic relevance.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Low cholesterol levels in children predict impulsivity in young adulthood

2019 ◽  
Vol 32 (4) ◽  
pp. 196-205
Author(s):  
Katrin Tomson-Johanson ◽  
Tanel Kaart ◽  
Raul-Allan Kiivet ◽  
Toomas Veidebaum ◽  
Jaanus Harro
Keyword(s):  
Young Adults ◽  
Birth Cohort ◽  
Young Adulthood ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Serum Lipid Levels ◽  
Low Levels

AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

scholarly journals Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Peng-Fei Zheng ◽  
Rui-Xing Yin ◽  
Yao-Zong Guan ◽  
Bi-Liu Wei ◽  
Chun-Xiao Liu ◽  
...  
Keyword(s):  
Ethnic Groups ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Notch Receptor ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Genotype Frequencies ◽  
The Relationship ◽  
Lipid Parameters

Abstract Background The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the Han and Maonan ethnic groups. Methods The genetic makeup of the SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs in 2467 unrelated subjects (Han, 1254; Maonan,1213) was obtained by using polymerase chain reaction and restriction fragment length polymorphism technique, combined with gel electrophoresis, and confirmed by direct sequencing. Results The genotype frequencies of SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs were different between Han and Maonan populations (P < 0.05); respectively. The SLC44A4 rs577272 SNP was associated with total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels in Maonan group. The NOTCH4 rs3134931 SNP was associated with triglyceride (TG) in Han; and TG and low-density lipoprotein cholesterol (LDL-C) levels in Maonan groups (P < 0.025–0.001). Stratified analysis according to gender showed that the SLC44A4 rs577272 SNP was associated with TC and HDL-C in Han and Maonan females; TC in Maonan males, meanwhile, the NOTCH4 rs3134931 SNP was associated with TG and HDL-C in Han males; TG in Han females; TG and LDL-C in Maonan males; and TG, HDL-C and LDL-C in Maonan females. Linkage disequilibrium analysis showed that the most common haplotype was rs577272G-rs3134931A (> 50%) in both Han and Maonan groups. The haplotype of rs577272G-rs3134931A was associated with TG and HDL-C in Han; and TC, TG and HDL-C in Maonan ethnic groups. Conclusions These results suggest that the relationship among SLC44A4 rs577272, NOTCH4 rs3134931 SNPs and serum lipid parameters may vary depending on the gender and/or ethnicity/race in some populations. Haplotypes could explain more changes in serum lipid parameters than any single SNP alone particularly for TC, TG and HDL-C.

scholarly journals Association Between Serum Lipid Levels, Resilience, and Self-Esteem in Japanese Adolescents: Results From A-CHILD Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Satomi Doi ◽  
Aya Isumi ◽  
Takeo Fujiwara
Keyword(s):  
Mental Health ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Self Esteem ◽  
Inverse Association ◽  
Lipid Levels ◽  
Child Study ◽  
Japanese Adolescents ◽  
Serum Lipid Levels

Previous studies have found that serum lipid levels independently associate with mental health problems in adulthood. However, little is known about the association between serum lipid levels and positive aspects of mental health such as resilience and self-esteem, which develop in adolescence. The aim of this study is to examine the association between serum lipid levels and resilience and self-esteem in Japanese adolescents. Data were pooled data from the Adachi Child Health Impact of Living Difficulty (A-CHILD) study in 2016 and 2018, a school-based, cross-sectional study in Adachi City, Tokyo, Japan (N = 1,056, aged 13–14 years). Resilience of the child was assessed by caregivers, and self-esteem was self-identified via questionnaires. Serum lipid levels [total cholesterol, low-density lipoproteins (LDL), and high-density lipoproteins (HDL)] were assessed in school health checkup, in addition to height and weight measurements. Multiple linear regression was applied to investigate the association between standardized serum lipid levels and resilience and self-esteem. LDL showed inverse association with resilience [β = −1.26, 95% confidence interval (CI) = −2.39 to −0.14] after adjusting for child’s BMI, month of birth, sex, absence of parent, household income, caregiver’s mental health, and lifestyle (e.g., habits of eating, physical activity, and sleep). We also found an inverse association of total cholesterol and higher LDL cholesterol with self-esteem (β = −0.58, 95% CI = −0.99 to −0.18; β = −0.42, 95% CI = −0.83 to −0.01, respectively). HDL cholesterol was not associated with resilience and self-esteem. Among Japanese adolescent, total and LDL cholesterol may be biomarkers of resilience and self-esteem.

scholarly journals The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males

Meta Gene ◽  
2013 ◽  
Vol 1 ◽  
pp. 58-64 ◽  
Author(s):  
Shu Su ◽  
Min Tang ◽  
Mingjun Zhang ◽  
Chunquan Cheng ◽  
Xiaojun Tang
Keyword(s):  
Gene Polymorphism ◽  
Serum Lipid ◽  
Han Chinese ◽  
Lipid Levels ◽  
Apolipoprotein Ciii ◽  
Serum Lipid Levels ◽  
The Relationship

The relationship between arterial compliance, age, blood pressure and serum lipid levels

1995 ◽  
Vol 13 (12) ◽  
pp. 1718???1723 ◽  
Author(s):  
James D. Cameron ◽  
Garry L. Jennings ◽  
Anthony M. Dart
Keyword(s):  
Blood Pressure ◽  
Serum Lipid ◽  
Arterial Compliance ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
The Relationship

scholarly journals Study of Association of Serum Lipid Levels with Migraine

2020 ◽  
Vol 10 (1) ◽  
pp. 27-32
Author(s):  
Mohammed Momenuzzaman Khan ◽  
Shajal Kumar Shil ◽  
Solaiman Hossain ◽  
Goutam Saha ◽  
Uttam Kumar ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Migraine With Aura ◽  
Serum Lipid ◽  
Migraine Without Aura ◽  
Ldl Cholesterol ◽  
Serum Total Cholesterol ◽  
Lipid Levels ◽  
Medical College ◽  
Serum Lipid Levels ◽  
Migraine Group

Background: Migraine is associated with increased prevalence of cardiovascular risk factors and vascular biomarkers and migraine with aura is associated with increased risk of ischemic stroke. Lipid abnormality is a risk factor for both cardiovascular and cerebrovascular disease. The vast majority of previous studies evaluated the association between lipid levels and migraine among young and middle aged persons abroad. So far we know, no study has been conducted in Bangladesh regarding association of lipid levels with migraine. Objectives: The present study is aimed to evaluate the association between serum lipid levels in patients with migraine. Materials and Methods: This observational, cross-sectional study was carried out on 100 patients in outpatient departments of Enam Medical College and Hospital, Dhaka and Mymensingh Medical College Hospital, Mymensingh over a period of one year (December 2017 to November 2018). Patients were selected by purposive sampling. Fifty migraine and 50 non-migraine patients were recruited in the study. Results: The serum total cholesterol and LDL-C were significantly higher in migraine than in non-migraine group. HDL-C was below normal and triglyceride was within normal range in both groups. Serum total cholesterol and LDL-C were significantly higher in migraine with aura than migraine without aura. HDL-C level was lower in migraine without aura and was of normal level in migraine with aura, which was statistically significant. Conclusion: Elevated levels of serum total cholesterol and LDL cholesterol were associated with migraine than non-migraine group. Serum total cholesterol and LDL cholesterol were significantly higher in late age of migraine group and migraine with aura. J Enam Med Col 2020; 10(1): 27-32

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