scholarly journals Low cholesterol levels in children predict impulsivity in young adulthood

2019 ◽  
Vol 32 (4) ◽  
pp. 196-205
Author(s):  
Katrin Tomson-Johanson ◽  
Tanel Kaart ◽  
Raul-Allan Kiivet ◽  
Toomas Veidebaum ◽  
Jaanus Harro
Keyword(s):  
Young Adults ◽  
Birth Cohort ◽  
Young Adulthood ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Serum Lipid Levels ◽  
Low Levels

AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

An Observational Study on the Association between Diabetic Retinopathy and Serum Lipid Levels in a Tertiary Centre in Thiruvananthapuram

2021 ◽  
Vol 8 (03) ◽  
pp. 131-135
Author(s):  
Kajal Seema S ◽  
Binu S.S ◽  
Bhaskar M.K.
Keyword(s):  
Diabetic Retinopathy ◽  
Observational Study ◽  
Total Cholesterol ◽  
Macular Oedema ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Diabetic Macular Oedema ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Serum Lipid Levels

BACKGROUND Dyslipidaemia has been proposed as a possible risk factor for diabetic retinopathy (DR) but results from previous studies are inconsistent. We designed this study to find the association of abnormal serum lipid levels with diabetic retinopathy and diabetic macular oedema (DME). METHODS This was a single centre observational study conducted at a tertiary care hospital, where patients with type 2 diabetes of more than five years duration were enrolled. A comprehensive ophthalmic evaluation was performed on all study subjects. Detailed fundoscopy was done after obtaining the best possible mydriasis with 1 % tropicamide and 5 % phenylephrine eye drops using direct ophthalmoscopy, indirect ophthalmoscopy with + 20 D lens and stereoscopic slit lamp biomicroscopy of the disc and macula using + 78 D Volk lens. Fundus photographs were taken in patients with any grade of diabetic retinopathy by Topcon fundus camera. DR and DME were diagnosed and classified according to the Early Treatment Diabetic Retinopathy Study (ETDRS) grading system. Fasting blood sugar (FBS), fasting lipid profile and glycated haemoglobin (HbA1c) was assessed for each patient. RESULTS A total of two hundred and twelve participants was enrolled. Mean age of the study group was 63.93 ± 9.52 and the mean duration of diabetes was 13.54 ± 6.07. DR was present in 164 (78.1 %) of whom 71 (43.3 %) had mild non proliferative diabetic retinopathy (NPDR), 42 (25.6 %) had moderate NPDR, 31 (18.9 %) had severe NPDR, and 20 (12.2 %) had proliferative diabetic retinopathy (PDR). Of those with DR, 59 (36 %) had DME. Duration of diabetes (14.62 ± 6.18 vs 9.72 ± 3.68 years, P < 0.001), higher fasting blood glucose (176.79 ± 59.13 vs 138.46 ± 49.44 mg / dL, P < 0.001), higher HbA1c (8.21 ± 1.38 vs. 7.48 ± 1.25 %, P = 0.002), higher total cholesterol (215.04 ± 49.78 vs 184.37 ± 30.84 mg / dL, P < 0.001), higher triglyceride levels (155.23 ± 59.06 vs 125.13 ± 37.3 mg / dL, P = 0.001) and higher low density lipoprotein (LDL) cholesterol levels (139.28 ± 37.38 vs 120.85 ± 22.75 mg / dL, P = 0.002) were significantly associated with the severity of DR. Higher total cholesterol, higher triglyceride levels and higher LDL cholesterol levels were also associated with DME. CONCLUSIONS There is a significant association of abnormal serum lipid levels and hyperglycaemia with the presence and severity of DR and presence of DME. Early identification and intervention to control these modifiable risk factors, hyperglycaemia and dyslipidaemia may delay the development and progression of DR in diabetic patients. These observations also support the current management strategies for diabetes, which include control of dyslipidaemia in addition to hyperglycaemia. KEYWORDS Diabetic Retinopathy, Diabetic Macular Oedema, Dyslipidaemia

scholarly journals Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4637 ◽  
Author(s):  
Xingchen Zhou ◽  
Wu Zhu ◽  
Minxue Shen ◽  
Yijing He ◽  
Cong Peng ◽  
...  
Keyword(s):  
Serum Level ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

scholarly journals The CXCL12 SNPs and their haplotypes are associated with serum lipid traits

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ling Qiu ◽  
Rui-Xing Yin ◽  
Rong-Jun Nie ◽  
Xi-Jiang Hu ◽  
Eksavang Khounphinith ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Serum Lipid ◽  
Direct Sequencing ◽  
Serum Triglyceride ◽  
Nucleotide Polymorphisms ◽  
Lipid Levels ◽  
Apo B ◽  
Cholesterol Levels ◽  
Serum Lipid Levels ◽  
Chemokine Ligand

AbstractThe relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the connection among the CXCL12 rs501120 and rs1746048 SNPs, haplotypes, several environmental factors and serum lipid traits in the Maonan as well as Han populations. Genotyping of the two SNPs, gel electrophoresis and direct sequencing were accomplished in 1,494 distinct subjects (Maonan, 750 and Han, 744) using polymerase chain reaction and restriction fragment length polymorphism. The frequencies of genotypes as well as alleles of the two SNPs were not similar between the two ethnic groups. The rs501120 SNP was related with serum total cholesterol levels, while the rs1746048 SNP was related with serum apolipoprotein (Apo) B levels. Four haplotypes were identified, of which the rs501120A-rs1746048C haplotype was the most common. The haplotypes of rs501120A-rs1746048T increased and rs501120G-rs1746048C decreased the risk of hyperlipidemia (P < 0.001 for each), showing consistent association with the levels of serum triglyceride, ApoA1 and ApoB. These outcomes specify that the CXCL12 SNPs as well as their haplotypes are related to serum lipid levels. Different serum lipid levels between both populations may partially be related to the CXCL12 SNPs, their haplotypes along with several environmental factors.

scholarly journals Association Between Serum Lipid Levels, Resilience, and Self-Esteem in Japanese Adolescents: Results From A-CHILD Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Satomi Doi ◽  
Aya Isumi ◽  
Takeo Fujiwara
Keyword(s):  
Mental Health ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Self Esteem ◽  
Inverse Association ◽  
Lipid Levels ◽  
Child Study ◽  
Japanese Adolescents ◽  
Serum Lipid Levels

Previous studies have found that serum lipid levels independently associate with mental health problems in adulthood. However, little is known about the association between serum lipid levels and positive aspects of mental health such as resilience and self-esteem, which develop in adolescence. The aim of this study is to examine the association between serum lipid levels and resilience and self-esteem in Japanese adolescents. Data were pooled data from the Adachi Child Health Impact of Living Difficulty (A-CHILD) study in 2016 and 2018, a school-based, cross-sectional study in Adachi City, Tokyo, Japan (N = 1,056, aged 13–14 years). Resilience of the child was assessed by caregivers, and self-esteem was self-identified via questionnaires. Serum lipid levels [total cholesterol, low-density lipoproteins (LDL), and high-density lipoproteins (HDL)] were assessed in school health checkup, in addition to height and weight measurements. Multiple linear regression was applied to investigate the association between standardized serum lipid levels and resilience and self-esteem. LDL showed inverse association with resilience [β = −1.26, 95% confidence interval (CI) = −2.39 to −0.14] after adjusting for child’s BMI, month of birth, sex, absence of parent, household income, caregiver’s mental health, and lifestyle (e.g., habits of eating, physical activity, and sleep). We also found an inverse association of total cholesterol and higher LDL cholesterol with self-esteem (β = −0.58, 95% CI = −0.99 to −0.18; β = −0.42, 95% CI = −0.83 to −0.01, respectively). HDL cholesterol was not associated with resilience and self-esteem. Among Japanese adolescent, total and LDL cholesterol may be biomarkers of resilience and self-esteem.

Affective disorders, psychosis and lipid levels: Is there a connection? Linking psychopathology, clinical exams and neurobiology

2017 ◽  
Vol 41 (S1) ◽  
pp. S765-S765
Author(s):  
M. Nascimento ◽  
M. Lázaro ◽  
J. Reis ◽  
G. Pereira ◽  
F. Bacelar ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Affective Disorders ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Depressive Mood ◽  
Serum Concentrations ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Psychotic Features ◽  
The Relationship

IntroductionPublished research regarding the relationship between lipid levels in affective disorders has been contradictory. Additionally, most studies correlating psychosis to lipid serum concentrations only concern schizophrenic patients.ObjectiveTo access the relationship between serum lipid levels with the diagnosis and pathophysiology of affective disorders.MethodsDiagnostic data (ICD–10: F31–32), including mood and psychotic features, were prospectively collected for all patients admitted at the affective disorder ward at Centro Hospitalar Psiquiátrico de Lisboa (Portugal), during the third trimester of 2016. Serum concentrations of triglycerides and total/HDL/LDL cholesterol were evaluated using standard laboratory tests. Statistical analysis was performed for possible correlations between serum lipid levels and:– different stages of bipolar disorder (BD);– elevated versus depressive mood (unipolar and bipolar);– depressive mood (BD versus non-BD);– psychotic features.ResultsSixty-three patients admitted were enrolled in this study: 47 presented with BD (32 manic, 10 depressives and 5 mixed episodes) and 16 presented depressive disorders. Statistical analysis (R software) revealed that depressed bipolar patients had significantly higher triglyceride (P = 0.026), total and LDL cholesterol (P = 0.525) levels than other states; mixed episodes presented higher HDL levels (P = 0.542). Although not significant, manic patients’ HDL levels were consistently elevated compared to depressive ones, whom presented with lower values overall. Finally, when adjusted for age, psychotic patients showed lower levels of total (P = 0.031) and LDL cholesterol (P = 0.052) compared to non-psychotic patients.ConclusionsThere is a potential link between serum lipid levels and diagnosis/psychopathology of affective disorders. Further research is needed to characterize its pathophysiologic relevance.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Serum Lipids are Novel Predictors for Thyroid Autoimmunity in the General Population with Normal TSH Levels From A Cross-Sectional Study

2021 ◽  
Author(s):  
Jiarong Li ◽  
Zixiao Wang ◽  
He Liu ◽  
Jinrong Fu ◽  
Fengye Qin ◽  
...  
Keyword(s):  
General Population ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Thyroid Autoimmunity ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Thyroid Autoantibody ◽  
Serum Lipid Levels ◽  
Tsh Levels

Abstract Objective Serum lipids have been shown to regulate inflammatory and immune processes, but little is known about their association with thyroid autoimmunity. This study aimed to investigate the association of serum lipids with thyroid autoantibody positivity in the general population with normal thyroid-stimulating hormone (TSH) levels. Methods Data regarding the 7,688 subjects’ baseline characteristics were retrospectively collected. All subjects were categorized into four groups according to thyroid autoantibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) positivity and serum lipid levels were compared. Binary logistic regression models were used to evaluate the risk of TgAb or TPOAb positivity with increasing serum lipid levels. Results In 6,456 included subjects, after adjusting for confounders, the risk of TgAb positivity was positively associated with increasing low-density lipoprotein cholesterol (LDL-C) levels (OR 1.10, 95%CI 1.02–1.19, P = 0.014) and negatively correlated with the increasing high-density lipoprotein cholesterol (HDL-C) levels (OR 0.80, 95%CI 0.67–0.96, P = 0.014). In female subjects, the association between increasing LDL-C (OR 1.15, 95%CI 1.05–1.26, P = 0.004) or HDL-C levels (OR 0.74, 95%CI 0.60–0.91, P = 0.005) and TgAb positivity become more pronounced. Moreover, there was a positive correlation between LDL-C levels and TPOAb positivity (OR 1.14, 95%CI 1.02–1.26, P = 0.016). Conclusion We have shown the associations of HDL-C and LDL-C with thyroid autoantibody positivity in the general population with normal TSH levels in a gender-dependent manner. This study highlights that serum lipids may be new predictors of thyroid autoimmunity even when TSH is within the reference range.

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