Potential therapeutic activities and novel delivery systems of chrysin-a nature’s boon

2021 ◽  
pp. 101316
Author(s):  
Shreya Adangale ◽  
Sarika Wairkar
RSC Advances ◽  
2015 ◽  
Vol 5 (92) ◽  
pp. 75575-75588 ◽  
Author(s):  
Charlotta D. Mock ◽  
Brian C. Jordan ◽  
Chelliah Selvam

This review focuses on recent developments in the use of curcumin, curcumin analogues, and novel delivery systems as a preventive and therapeutic method for breast cancer treatment.


2021 ◽  
Vol 14 (10) ◽  
pp. 946
Author(s):  
Bianca Enaru ◽  
Sonia Socaci ◽  
Anca Farcas ◽  
Carmen Socaciu ◽  
Corina Danciu ◽  
...  

Liposome-based delivery systems have been studied and used more frequently in recent years due to their advantages, such as low toxicity, specificity, and the ability to protect the encapsulated substance from environmental factors, which could otherwise degrade the active compound and reduce its effectiveness. Given these benefits, many researchers have encapsulated polyphenols in liposomes, thus increasing their bioavailability and stability. Similarly, polyphenols encapsulated in liposomes are known to produce more substantial effects on targeted cells than unencapsulated polyphenols, while having minimal cytotoxicity in healthy cells. Although polyphenols play a role in preventing many types of disease and generally have beneficial effects on health, we solely focused on their chemopreventive effects on cancer through liposomes in this review. Our goal was to summarize the applicability and efficacy of liposomes encapsulated with different classes of polyphenols on several types of cancer, thus opening the opportunity for future studies based on these drug delivery systems.


2022 ◽  
Vol 2022 ◽  
pp. 1-9
Author(s):  
Sara Assadpour ◽  
Mohammad Reza Shiran ◽  
Peyman Asadi ◽  
Javad Akhtari ◽  
Amirhossein Sahebkar

Sumatriptan (ST) is a commonly prescribed drug for treating migraine. The efficiency of several routes of ST administration has been investigated. Recently, the intranasal route with different delivery systems has gained interest owing to its fast-acting and effectiveness. The present study is aimed at reviewing the available studies on novel delivery systems for intranasal ST administration. The oral route of ST administration is common but complicated with some problems. Gastroparesis in patients with migraine may reduce the absorption and effectiveness of ST upon oral use. Furthermore, the gastrointestinal (GI) system and hepatic metabolism can alter the pharmacokinetics and clinical effects of ST. The bioavailability of conventional nasal liquids is low due to the deposition of a large fraction of the delivered dose of a drug in the nasal cavity. Several delivery systems have been utilized in a wide range of preclinical and clinical studies to enhance the bioavailability of ST. The beneficial effects of the dry nasal powder of ST (AVP-825) have been proven in clinical studies. Moreover, other delivery systems based on microemulsions, microspheres, and nanoparticles have been introduced, and their higher bioavailability and efficacy were demonstrated in preclinical studies. Based on the extant findings, harnessing novel delivery systems can improve the bioavailability of ST and enhance its effectiveness against migraine attacks. However, further clinical studies are needed to approve the safety and efficacy of employing such systems in humans.


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