Comprehensive chemical characterization and biological evaluation of two Acacia species: A. nilotica and A. ataxacantha

2021 ◽  
pp. 112446
Author(s):  
Dimitrina Zheleva-Dimitrova ◽  
Kouadio Ibrahime Sinan ◽  
Ouattara Katinan Etienne ◽  
Gunes Ak ◽  
Jugreet B. Sharmeen ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Biological Evaluation ◽  
Acacia Species

scholarly journals Chemical and biological evaluation of rejects from the wood industry

2005 ◽  
Vol 48 (spe) ◽  
pp. 237-241 ◽  
Author(s):  
Daniel Granato ◽  
Domingos Sávio Nunes ◽  
Patrícia Póvoa de Mattos ◽  
Ester de Moura Rios ◽  
Adeline Glinski ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Ethyl Acetate Extract ◽  
Micrococcus Luteus ◽  
Chemical Characterization ◽  
Enterobacter Aerogenes ◽  
Ethanol Extract ◽  
Biological Evaluation ◽  
Wood Industry ◽  
Anatomical Studies ◽  
E Coli

This study aimed chemical characterization and microbiological evaluation of extracts obtained from the waste of woods marketed in Paraná State: Peroba-Rosa (Aspidosperma sp.), Roxinho (Peltogyne sp.), Jatobá(Hymenaea sp.), Curupixá (Micropholis sp.), Itaúba (Mezilaurus sp.), Cedrilho (Erisma sp.) and Imbúia (Licaria sp.), whose botanical identifications were based on anatomical studies. The extracts were prepared with different solvents, analyzed by TLC and UV/VIS techniques, and tested against: Proteus mirabilis ATCC15290, Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922, Enterobacter aerogenes ATCC13048, Micrococcus luteus ATCC9341, Klebsiella pneumoniae ATCC13883, Pseudomonas aeroginosa ATCC27853, Staphylococcus aureus, Streptococcus mutans and Bacillus cereus isolated from the clinic. The ethanol extract from Peroba-rosa containing alkaloids showed activity against P. mirabilis. Itaúba, Jatobá and Imbúia methanol extracts containing phenolics, and the Roxinho ethyl acetate extract containing terpenoids and phenolics were active against K. pneumoniae, M. luteus, E. coli, S. aureus and P. mirabilis. P. aeroginosa, S. mutans and E. aerogenes were resistant to the extracts.

scholarly journals Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of α V β 3 Integrin Activity

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jamila Hedhli ◽  
Andrzej Czerwinski ◽  
Matthew Schuelke ◽  
Agata Płoska ◽  
Paweł Sowinski ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Biological Evaluation ◽  
Targeted Imaging

Safety Evaluation of Medical Devices: US Food and Drug Administration and International Standards Organization Guidelines

1999 ◽  
Vol 18 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Sharon J. Northup
Keyword(s):  
Medical Devices ◽  
Degradation Products ◽  
Blood Compatibility ◽  
Developmental Toxicity ◽  
Safety Evaluation ◽  
Chemical Characterization ◽  
Biological Evaluation ◽  
International Standards ◽  
Screening Tests ◽  
Mechanisms Of Toxicity

During the last 20 years, safety evaluation of medical devices has evolved from screening assays to the “pharmaceutical model” of preclinical testing. Biocompatibility testing guidelines for medical devices are published in the International Organization for Standardization (ISO) document 10993–1: Biological evaluation of medical devices—Part 1: Evaluation and testing. These guidelines are recognized by most national regulatory bodies and supplement, but do not supersede, the guidelines published by the individual nations or the testing requirements for a specific medical device. The ISO 10993 series includes screening tests for nonspecific mechanisms of toxicity (cytotoxicity, acute systemic toxicity, subchronic toxicity, local toxicity, and chronic toxicity) and specific mechanisms (blood compatibility, genotoxicity, carcinogenicity, pyrogenicity, and reproductive and developmental toxicity). Other ISO 10993 standards cover chemical characterization of materials, degradation products, toxicokinetics, sample preparation, permissible limits of sterilization and process residues, and clinical studies. This review examines the scope of these standards and identifies exceptions between these guidelines and selected national and vertical standards for medical devices.

scholarly journals Micelle-forming HPMA copolymer conjugates of ritonavir bound via a pH-sensitive spacer with improved cellular uptake designed for enhanced tumor accumulation

2016 ◽  
Vol 4 (47) ◽  
pp. 7620-7629 ◽  
Author(s):  
E. Koziolová ◽  
D. Machová ◽  
R. Pola ◽  
O. Janoušková ◽  
P. Chytil ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Controlled Drug Release ◽  
Biological Evaluation ◽  
Hpma Copolymer ◽  
Design Synthesis ◽  
Drug Conjugates ◽  
Physico Chemical ◽  
Tumor Accumulation ◽  
Polymer Drug Conjugates ◽  
Hpma Copolymer Conjugates

We describe design, synthesis, physico-chemical characterization and preliminary biological evaluation of micelle-forming polymer drug conjugates with controlled drug release intended for tumor treatment.

Physico-chemical characterization and biological evaluation of two fibroin materials

2012 ◽  
Vol 8 (11) ◽  
pp. 874-885 ◽  
Author(s):  
Antonella Motta ◽  
Paola Segnana ◽  
Lucia Verin ◽  
Silvia La Monica ◽  
Claudia Fumarola ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Biological Evaluation ◽  
Physico Chemical
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