Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75NTR signaling disruption

2021 ◽  
pp. 112614
Author(s):  
Paula Moyano ◽  
Andrea Flores ◽  
Jimena García ◽  
José Manuel García ◽  
María José Anadon ◽  
...  
Keyword(s):  
Cell Death ◽  
Bisphenol A ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Repeated Treatment ◽  
Cholinergic Neurotransmission

scholarly journals Astaxanthin Inhibits Autophagic Cell Death Induced by Bisphenol A in Human Dermal Fibroblasts

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1273
Author(s):  
Seong-Ryeong Lim ◽  
Do-Wan Kim ◽  
Junghee Sung ◽  
Tae Hoon Kim ◽  
Chang-Hyung Choi ◽  
...  
Keyword(s):  
Cell Death ◽  
Bisphenol A ◽  
Apoptotic Cell ◽  
Dermal Fibroblasts ◽  
Apoptotic Cell Death ◽  
Autophagic Cell Death ◽  
Mitogen Activated Protein Kinase ◽  
Ros Production ◽  
Human Dermal Fibroblasts ◽  
Endocrine Disrupting Chemical

Astaxanthin, a natural antioxidant carotenoid, is a nutrient with diverse health benefits, given that it decreases the risk of oxidative stress-related diseases. In the present study, we investigate the functional role of astaxanthin during autophagic cell death induced by the estrogenic endocrine-disrupting chemical bisphenol A (BPA) in normal human dermal fibroblasts (NHDF). BPA significantly induced apoptotic cell death and autophagy in NHDF. Autophagic cell death evoked by BPA was significantly restored upon a treatment with astaxanthin (10 μM) via the inhibition of intracellular reactive oxygen species (ROS) production. Astaxanthin inhibited the phosphorylation of extracellular signal-regulated kinases (ERK) stimulated by ROS production, but it did not influence the activation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in BPA-treated NHDF. Astaxanthin abrogated the ERK-mediated activation of nuclear factor-kappa B (NF-κB), which is responsible for the mRNA expression of LC3-II, Beclin-1, Atg12, and Atg14 during apoptotic cell death induced by BPA. These results indicate that astaxanthin is a pharmacological and nutritional agent that blocks the skin fibroblastic autophagic cell death induced by BPA in human dermal fibroblasts.

The protective effect of lipophilic iron chelator 2, 2′-dipyridyl after focal cerebral ischemia closely correlates with limitation of apoptotic cell death

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S482-S482
Author(s):  
Michaël C Van Hoecke ◽  
Anne Prigent-Tessier ◽  
Philippe E Garnier ◽  
Christine Marie ◽  
Alain Beley
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Protective Effect ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Iron Chelator ◽  
Apoptotic Cell Death

KIOM-79 prevents apoptotic cell death and AGEs accumulation in the retina of diabetic db/db mice

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
YS Kim ◽  
EJ Sohn ◽  
HY Lee ◽  
CS Kim ◽  
YM Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

Diabetes ◽  
1995 ◽  
Vol 44 (7) ◽  
pp. 733-738 ◽  
Author(s):  
H. Kaneto ◽  
J. Fujii ◽  
H. G. Seo ◽  
K. Suzuki ◽  
T. Matsuoka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death
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