Parental karyotype and subsequent live births in recurrent miscarriage

2004 ◽  
Vol 81 (5) ◽  
pp. 1296-1301 ◽  
Author(s):  
Howard Carp ◽  
Baruch Feldman ◽  
Gabriel Oelsner ◽  
Eyal Schiff
Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1350
Author(s):  
Veronika Günther ◽  
Ibrahim Alkatout ◽  
Lisa Meyerholz ◽  
Nicolai Maass ◽  
Siegfried Görg ◽  
...  

Although many potential causes have been established for recurrent implantation failure (RIF) and recurrent miscarriage (RM), about 50% of these remain idiopathic. Scientific research is focused on immunological risk factors. In the present study, we aim to evaluate live birth rates after immunization with paternal lymphocytes (lymphocyte immunotherapy (LIT)). This retrospective study consisted of 148 couples with a history of RM and/or RIF. The women underwent immunization with lymphocytes of their respective partners from November 2017 to August 2019. Fifty-five patients (43%) had live births. Stratified by indication (RM, RIF, combined), live birth rates in the RM and the combined group were significantly higher than that in the RIF group (53%, 59% and 33%, respectively, p = 0.02). The difference was especially noticeable during the first 90 days after immunization (conception rate leading to live births: 31%, 23% and 8% for RM, the combined group and RIF, respectively; p = 0.005), while there was no difference between groups during the later follow-up. LIT was associated with high live birth rates, especially in women with recurrent miscarriage. In view of the limited data from randomized studies, LIT cannot be recommended as routine therapy. However, it may be considered in individual cases.


2010 ◽  
Vol 25 (11) ◽  
pp. 2745-2752 ◽  
Author(s):  
H. S. Nielsen ◽  
F. Wu ◽  
Z. Aghai ◽  
R. Steffensen ◽  
A. G. van Halteren ◽  
...  

Author(s):  
Mamatha B. Shetty ◽  
Mounica Malyala ◽  
Asha Swarup ◽  
Suneha Pocha ◽  
Davis Sabu Pathadan ◽  
...  

Background: Recurrent pregnancies loss (RPL) is physically and emotionally devastating situation for the parents, along with difficult situation for obstetrician to handle. Present study aimed at investigation of the significance of various etiology in relation to pregnancy outcome in cases of recurrent pregnancy loss.Methods: It is a retrospective analysis of patients who presented to M. S. Ramaiah Medical college with recurrent miscarriage between April 2014 and August 2015. ANA was done on the basis of clinical and laboratory data which was obtained and eventually diagnosis was made. The study results were analysed in terms of term live births, maternal and fetal complications.Results: Out of the RPL cases that were studied, 78 patients came with recurrent pregnancy loss. Out of these cases, endocrine abnormalities, like diabetes mellitus and hypothyroidism were the maximum 26.92% and 12.82% respectively. Followed by unexplained causes were 37.3%. Thrombophila and APLA positive cases constituted for 16.66% and 3.4% respectively. ANA positive and cervical incompetence were 6.4% each.Conclusions: Recurrent pregnancy loss is very difficult situation to handle. Various etiology need various specialists, and requirements, and management mainly depends on the cause for recurrent pregnancy loss.


2007 ◽  
Author(s):  
Erica A. Tennenbaum ◽  
Merle A. Keitel ◽  
Diana Dibuono ◽  
Giovanna Forte

2015 ◽  
Vol 18 (3) ◽  
pp. 109
Author(s):  
Huseyin Saskin ◽  
Mustafa Idiz ◽  
Cagri Duzyol ◽  
Huseyin Macika ◽  
Rezan Aksoy

Pulmonary agenesis is associated with the absence of pulmonary vessels, bronchi, or parenchyma. This condition usually occurs between the 4th and 5th week of gestation during the embryonic phase. Etiopathogenic factors associated with pulmonary agenesis are not fully understood. In the literature, genetic and teratogenic factors, viral infections, and vitamin-A deficiency are shown to be associated with pulmonary agenesis [Malcon 2012]. This condition may be seen unilaterally or bilaterally. Although the precise rate of incidence is unknown, it is estimated to occur in one of every 10,000 to 12,000 live births [Yetim 2011]. There is a 1.3:1 female predominance with unilateral agenesis [Halilbasic 2013]


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