Embryo transfer factors that may alter clinical pregnancy rates: an observational, cohort study

Background: Whether serum progesterone (P4) level on the day of human chorionic gonadotropin (hCG) trigger is related to the outcome of artificial reproductive technology (ART) is still a debatable issue. The objective of this study was to evaluate relationship between serum Progesterone levels on the day of hCG trigger and ICSI outcome.Method: This was a retrospective, non-interventional, observational, cohort study of patients undergoing ICSI at 21st Century Group of Hospitals, Killa Pardi and Surat, Gujarat during the period of January 2018 to March 2018. Patients with age group of 20-40 years who underwent ICSI-ET using GnRH antagonist flexible protocol during this period, had obtained 2 or more MII oocytes during retrieval and had at least one grade I embryo transferred were included in this study. Women using donor oocytes were excluded. Serum progesterone levels were analysed on day of hCG trigger. Total 165 patients were included in the study. They were divided into two groups, those with β-hCG less than or equal to 1.5 ng/ml and those with β-hCG more than 1.5 ng/ml. Student's t test and Chi square test were used to compare the clinical pregnancy rates between two groups.Results: Clinical pregnancy rate decreases with increase in serum progesterone levels on the day of hCG trigger. Patients with serum progesterone levels ≤1.5 ng/ml had significantly higher clinical pregnancy rates than those with progesterone levels >1.5 ng/ml (45% vs 6%; p :<0.001).Conclusion: Pre-hCG rise in serum Progesterone concentration does not affect the oocyte quality. But, it significantly decreases the chances of implantation and the clinical pregnancy rates.

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Comparative Study Between Mock Embryo Transfer Prior To The Treatment Cycle and Real Embryo Transfer In In Vitro Fertilization

KnE Medicine ◽

10.18502/kme.v1i1.538 ◽

2016 ◽

Vol 1 (1) ◽

Author(s):

Hilma Putri Lubis

Keyword(s):

In Vitro Fertilization ◽

Embryo Transfer ◽

Treatment Cycle ◽

Uterine Cavity ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Vitro Fertilization ◽

Significant Difference ◽

Clinical Pregnancy Rates

IntroductionA trial or mock embryo transfer (ET) may influence pregnancy rates and it performed prior to ET allows the clinician to assess the uterine cavity and the utero-cervical angle. The aim of this study is to compare the consistency of the type of ET in mock ET with real ET.Material & MethodsA retrospective comparative analysis of patients who underwent in vitro fertilization or ICSI cycle from January 2014 to December 2014 in Halim Fertility Center was done. The type of transfer was divided into two groups: ‘easy’ or ‘difficult’. An easy ET was defined as a transfer that occurred without the use of manipulation or other instrumentation and difficult ET was considered when additional instrumentation was required.ResultsFrom the study, 103 patients who underwent Mock-ET, we found 58 patients (56.3%) with easy ET and 45 patients (43.7%) with difficult ET, which with hard catheter ET in 17 patients (16.5%), with osfander assistance in 20 patients (19.4%) and with stylet in 8 patients (7,8%). 58 patients with Easy Mock ET group were entirely easy real ET (100%) and 45 patients with difficult Mock ET group also entirely were difficult real ET (100%). The Statistical analysis shows no significant difference between the mock ET and real ET groups (p>0,05). In easy real ET, clinical pregnancy rates were 32.8% and in difficult real ET, clinical pregnancy rates were 26.7% with no significant difference between the groups (p>0,05).Conclusion:Mock ET prior to the treatment cycle is consistent with real ET.

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The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i9.7664 ◽

2020 ◽

Author(s):

Robab Davar ◽

Soheila Pourmasumi ◽

Banafsheh Mohammadi ◽

Maryam Mortazavi Lahijani

Keyword(s):

Clinical Trial ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Low Dose ◽

Endometrial Thickness ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Clinical Pregnancy Rates

Background: The results of previous studies on the effect of low-dose aspirin in frozenthawed embryo transfer (FET) cycles are limited and controversial. Objective: To evaluate the effect of low-dose aspirin on the clinical pregnancy in the FET cycles. Materials and Methods: This study was performed as a randomized clinical trial from May 2018 to February 2019; 128 women who were candidates for the FET were randomly assigned to two groups receiving either 80 mg oral aspirin (n = 64) or no treatment. The primary outcome was clinical pregnancy rate and secondary outcome measures were the implantation rate, miscarriage rate, and endometrial thickness. Results: The endometrial thickness was lower in patients who received aspirin in comparison to the control group. There were statistically significant differences between the two groups (p = 0.018). Chemical and clinical pregnancy rates and abortion rate was similar in the two groups and there was no statistically significant difference. Conclusion: The administration of aspirin in FET cycles had no positive effect on the implantation and the chemical and clinical pregnancy rates, which is in accordance with current Cochrane review that does not recommend aspirin administration as a routine in assisted reproductive technology cycles. Key words: Aspirin, Embryo transfer, Pregnancy rates.

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Do Multiple Attempts at Embryo Transfer Affect Clinical Pregnancy Rates?

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/s1701-2163(15)30586-7 ◽

2014 ◽

Vol 36 (5) ◽

pp. 406-407 ◽

Cited By ~ 3

Author(s):

Ayman Oraif ◽

Jackie Hollet-Caines ◽

Valter Feyles ◽

Maggie Rebel ◽

Hanin Abduljabar

Keyword(s):

Embryo Transfer ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rates

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The effect of embryo transfer loading volume on clinical pregnancy rates in normoresponders underwent long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.07.417 ◽

2013 ◽

Vol 100 (3) ◽

pp. S463

Author(s):

S. Guven ◽

E. Odaci ◽

E. Yulug ◽

C. Kart ◽

M. Unsal ◽

...

Keyword(s):

Embryo Transfer ◽

Intracytoplasmic Sperm Injection ◽

Single Embryo Transfer ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rates

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Effectiveness of highly purified HMG plus r-FSH vs r-FSH alone vs r-FSH plus r-LH in IVF-ET/ ICSI patients：a retrospective cohort study

10.21203/rs.3.rs-81451/v1 ◽

2020 ◽

Author(s):

Zhong-Kai Wang ◽

She-ling Wu ◽

Xiao-Na Yu ◽

Hong-Wu Qiao ◽

Hua Lou ◽

...

Keyword(s):

Cohort Study ◽

Subgroup Analysis ◽

Retrospective Cohort Study ◽

Ovulation Induction ◽

Retrospective Cohort ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Current Standard ◽

Significant Difference ◽

Clinical Pregnancy Rates

Abstract Objective: To evaluate the effectiveness of highly purified human menopausal gonadotropins (hp-HMG) plus recombinant follicle stimulating hormone (r-FSH) vs r-FSH vs r-FSH plus recombinant luteinizing hormone （r-LH） in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) patients。Design :Retrospective cohort studyMethods:This was a retrospective study. Among a total number of 3568 patients who had undergone IVF/ICSI applications, 409 eligible patients were included.Total units of follitropin alpha preparations used in ovulation induction, total number of meiois-2 phase oocytes, total number of used oocytes in ICSI cycle, fertilization rate and clinical pregnancy rates of both groups were analyzed. In this retrospective cohort study, women undergoing IVF/ICSI Gonadotropin releasing hormone (GnRH) antagonist cycles downregulation. 409 patients were included in the study. Among them One group followed the current standard protocol of no LH or hp-HMG supplementation given(n=64). The other had LH supplementation in the form of r -LH (Luveris; Merck Serono, Switzerland) (n=221), Another group had hp-HMG supplementation in the form of hp-HMG (Menopur , Ferring,Germany)(n=121).In the Subgroup analysis were decided by AFC ,7 < AFC〈20 or AFC>20 of the three group.Result: Mean duration of stimulation and was longer in the group of patients treated with hp-HMG plus rFSH compared to the group of patients treated with r-FSH and the group of r-LH plus r-FSH (13.24 days and 12.72days and12.21days, respectively; P<0.05). The amount of GN does for patients treated withhp-HMG plus rFSH compared to the group of patients treated with r-FSH plus r-LH and the group of r-FSH alone respectively (P<0.05). Clinical pregnancy rates were 76.6% and 60.9% and 62.9% （P<0.05）in the groups of patients treated with hp-hMG plus rFSH, r-FSH plus r-LH,r-FSHalonerespectively. What’s morea greater live birth rate was noted in the hp-hMG plus r-FSH group, there was statistically significant difference between the three groups (P>0.05).in the subgroup analysis when AFC>20 hp-HMG plus rFSH group have more lower ovarian hyperstimulation syndrome （OHSS） than r-FSH plus r-LH and rFSH alone,respectively.Clonclusion:The higher oocyte yield with r-FSH does not result in higher quality embryos.hp-HMG or r-LH supplementation is an option for improving IVF outcome in patients ovulation induction with r-FSH during GnRH agonist down-regulation. Particularly, hp-HMG is recommended as it may have a beneficial action on implantation in selected group especially AFC more than 20patients.

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