Donor oocytes are associated with preterm birth when compared to fresh autologous in vitro fertilization cycles in singleton pregnancies

The aim of our study was to determine the effect of infertility and the method of fertilization on the frequency of preterm birth and low birth weight in singleton pregnancies achieved by in vitro fertilization (IVF). The study was conducted in the period 01.2013 - 12.2017 and included 286 patients with births from singleton IVF pregnancies. Classical IVF received 107 patients (group A1) and ICSI fertilization - 148 (group A2). Cases with tubal infertility were 81 (group B1), and 85 were with male infertility (group B2). In group A1, birth prior to 37 weeks of gestation (w.g.) was found in 33 (30.8%) cases, compared to 26 (17.6%) in group A2 (p=0.029).In group A1, birth weight <2500 g was observed in 27 (25.3%) of cases, and in group A2 - in 17 (11.5%) of cases (p=0.015). In group B1, birth prior to 37 w.g. was established in 26 (32.1%) of the cases, compared to 9 (10.6%) in group B2 (p=0.003). In group B1 there was birth weight <2500 g in 19 (23.5%) of patients, compared to 6 (7.1%) in group B2 (p = 0.009). The average weight of the newborn and average duration of pregnancy was lower in groups with IVF fertilization and tubal infertility compared to ICSI fertilization and male infertility. Tubal infertility and classical IVF fertilization are independent risk factors that increase the frequency of preterm birth and low birth weight in IVF singleton pregnancies.

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Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization–embryo transfer or gamete intrafallopian transfer: A meta-analysis

Fertility and Sterility ◽

10.1016/j.fertnstert.2004.06.038 ◽

2004 ◽

Vol 82 (6) ◽

pp. 1514-1520 ◽

Cited By ~ 133

Author(s):

Peter G. McGovern ◽

Amaury J. Llorens ◽

Joan H. Skurnick ◽

Gerson Weiss ◽

Laura T. Goldsmith

Keyword(s):

Preterm Birth ◽

In Vitro Fertilization ◽

Embryo Transfer ◽

Meta Analysis ◽

Gamete Intrafallopian Transfer ◽

Vitro Fertilization ◽

Increased Risk ◽

Singleton Pregnancies

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Preterm Birth and Small Size for Gestational Age in Singleton, In Vitro Fertilization Births Using Donor Oocytes

American Journal of Epidemiology ◽

10.1093/aje/kwy051 ◽

2018 ◽

Vol 187 (8) ◽

pp. 1642-1650 ◽

Cited By ~ 4

Author(s):

Sheree L Boulet ◽

Jennifer F Kawwass ◽

Sara Crawford ◽

Michael J Davies ◽

Dmitry M Kissin

Keyword(s):

Preterm Birth ◽

In Vitro Fertilization ◽

Gestational Age ◽

Vitro Fertilization ◽

Donor Oocytes

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Does donor sperm affect birth weight (BW), preterm birth (PB), And miscarriage rates in fresh autologous in vitro fertilization (IVF) cycles? analysis of 46,061 cycles reported to SART

Fertility and Sterility ◽

10.1016/j.fertnstert.2017.02.055 ◽

2017 ◽

Vol 107 (3) ◽

pp. e30 ◽

Cited By ~ 1

Author(s):

Rani Fritz ◽

Sangita K. Jindal ◽

Bo Yu ◽

Mario G. Vega ◽

Erkan Buyuk

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

In Vitro Fertilization ◽

Donor Sperm ◽

Vitro Fertilization

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Fertility Treatments and the Risk of Preterm Birth Among Women with Subfertility: A Linked-Data Retrospective Cohort Study

10.21203/rs.3.rs-206714/v1 ◽

2021 ◽

Author(s):

Jessica N Sanders ◽

Sara E Simonsen ◽

Christina A Porucznik ◽

Ahmad O Hammoud ◽

Ken Smith ◽

...

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

In Vitro Fertilization ◽

Retrospective Cohort ◽

Fetal Death ◽

Perinatal Outcomes ◽

Birth Certificates ◽

Vitro Fertilization ◽

Fertility Treatments

Abstract Background: In vitro fertilization (IVF) births contribute to a considerable proportion of preterm birth (PTB) each year. However, there is no formal surveillance of adverse perinatal outcomes for less invasive fertility treatments. The study objective was to determine the effect of fertility treatment (in vitro fertilization, intrauterine insemination, usually with ovulation drugs (IUI), or ovulation drugs alone) on preterm birth, compared to no treatment in subfertile women.Methods: The Fertility Experiences Study (FES) is a retrospective cohort study conducted at the University of Utah between April 2010 and September 2012. Women with a history of primary subfertility self-reported treatment data via survey and interviews. Participant data were linked to birth certificates and fetal death records to asses for perinatal outcomes, particularly preterm birth.Results: A total 487 birth certificates and 3 fetal death records were linked as first births for study participants who completed questionnaires. Among linked births, 19% had a PTB. After adjustment for maternal age, paternal age, maternal education, annual income, religious affiliation, female or male fertility diagnosis, and duration of subfertility, the odds ratios and 95% confidence intervals (CI) for PTB were 2.17 (CI: 0.99, 4.75) for births conceived using ovulation drugs, 3.17 (CI: 1.4, 7.19) for neonates conceived using IUI and 4.24 (CI: 2.05, 8.77) for neonates conceived by IVF, compared to women with subfertility who used no treatment during the month of conception. A reported diagnosis of female factor infertility increased the adjusted odds of having a PTB 2.99 (CI: 1.5, 5.97). Duration of pregnancy attempt was not independently associated with PTB. In restricting analyses to singleton gestation, odds ratios remained elevated but were not significant for any type of treatment.Conclusion: IVF, IUI, and ovulation drugs were all associated with a higher incidence of preterm birth and low birth weight, predominantly related to multiple gestation births.

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Preterm and premature rupture of membranes in pregnancies after in vitro fertilization

Medicinski pregled ◽

10.2298/mpns0508375t ◽

2005 ◽

Vol 58 (7-8) ◽

pp. 375-379 ◽

Cited By ~ 2

Author(s):

Dunja Tabs ◽

Tihomir Vejnovic ◽

Nebojsa Radunovic

Keyword(s):

In Vitro Fertilization ◽

Intrauterine Insemination ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Fertilization Program ◽

Vitro Fertilization ◽

Preterm Premature Rupture ◽

Natural Conception ◽

Singleton Pregnancies

Women conceiving by assisted reproduction are at higher risk for preterm and premature rupture of membranes. The aim of our study was to estimate and compare incidence of preterm premature rupture of membranes in singleton pregnancies of women who conceived by intrauterine insemination and in vitro fertilization, from 1999 to 2003. We investigated 87 women from the intrauterine insemination, and 102 from the in vitro fertilization program. There were no statistically significant differences in regard to preterm and premature rupture of membranes: p>0.75 in two groups. The incidence of premature rupture of membranes was 2.30% (after intrauterine insemination) and 2.94% (after in vitro fertilization). There was no statistically significant differences in regard to preterm and premature rupture of membranes in women who conceived by insemination and in vitro fertilization. Estimated incidence of preterm and premature rupture of membranes was similar to the literature data and also similar to incidence after natural conception.

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