Xanthones and benzophenones isolated from the endophytic fungus Penicillium sp. ct-28 of Corydlis tomentella and their cytotoxic activity

Two new verrucosidin derivatives, named nordeoxyverrucosidin (1) and norverrucosidinol acetate (2), along with three known analogues (3–5) were isolated from the marine-derived fungus Penicillium sp. XL-01 collected from the Bohai Sea. Their structures and relative configurations were elucidated by comparing with literature data and a combination of spectroscopic techniques. The absolute configuration of 1 was assigned by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. Compounds 1 and 3 displayed promising cytotoxic activity against the MGC-803 cell line, with IC50 values of 0.96 and 1.14 μM, respectively, more effective than the positive control (cisplatin).

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An antimicrobial alkaloid and other metabolites produced by Penicillium sp. An endophytic fungus isolated from Mauritia flexuosa L. f.

Química Nova ◽

10.1590/s0100-40422012000400022 ◽

2012 ◽

Vol 35 (4) ◽

pp. 771-774 ◽

Cited By ~ 19

Author(s):

Hector Henrique Ferreira Koolen ◽

Elzalina Ribeiro Soares ◽

Felipe Moura Araújo da Silva ◽

Richardson Alves de Almeida ◽

Afonso Duarte Leão de Souza ◽

...

Keyword(s):

Endophytic Fungus ◽

Penicillium Sp ◽

Mauritia Flexuosa

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Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.

Fitoterapia ◽

10.1016/j.fitote.2016.11.008 ◽

2017 ◽

Vol 116 ◽

pp. 72-76 ◽

Cited By ~ 15

Author(s):

Ming-Hua Yang ◽

Tian-Xiao Li ◽

Ying Wang ◽

Rui-Huan Liu ◽

Jun Luo ◽

...

Keyword(s):

Endophytic Fungus ◽

Penicillium Sp ◽

Antimicrobial Metabolites

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Penibruguieramine A, a Novel Pyrrolizidine Alkaloid from the Endophytic Fungus Penicillium sp. GD6 Associated with Chinese Mangrove Bruguiera gymnorrhiza

Organic Letters ◽

10.1021/ol5001523 ◽

2014 ◽

Vol 16 (5) ◽

pp. 1390-1393 ◽

Cited By ~ 47

Author(s):

Zhen-Fang Zhou ◽

Tibor Kurtán ◽

Xiao-Hong Yang ◽

Attila Mándi ◽

Mei-Yu Geng ◽

...

Keyword(s):

Endophytic Fungus ◽

Pyrrolizidine Alkaloid ◽

Bruguiera Gymnorrhiza ◽

Penicillium Sp

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A subchronic toxicity test of ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih (Curcuma zedoaria) against Swiss albino mice

Journal of Chinese Pharmaceutical Sciences ◽

10.5246/jcps.2018.02.014 ◽

2018 ◽

Vol 27 (2) ◽

pp. 123-130

Author(s):

Yohandini Heni

Keyword(s):

Ethyl Acetate ◽

Endophytic Fungus ◽

Toxicity Test ◽

Ethyl Acetate Extract ◽

Curcuma Zedoaria ◽

Subchronic Toxicity ◽

Swiss Albino Mice ◽

Penicillium Sp ◽

Albino Mice

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Chemical Constituents from an Endophytic Fungus Chaetomium Globosum Z1

Natural Product Communications ◽

10.1177/1934578x1300800907 ◽

2013 ◽

Vol 8 (9) ◽

pp. 1934578X1300800

Author(s):

Chun-Yan Zhang ◽

Xiao Ji ◽

Xuan Gui ◽

Bao-Kang Huang

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Endophytic Fungus ◽

Chemical Constituents ◽

2D Nmr ◽

Chaetomium Globosum ◽

Spectroscopic Methods ◽

Esi Ms

A new ergosterol, 15β-hydroxyl-(22 E,24 R)-ergosta-3,5,8,22-tetraen-one (1), along with three known ergosterols, two known cytochalasins, and two known azapholines were isolated from Chaetomium globosum Z1. The structures of these compounds were elucidated on the basis of spectroscopic methods (HR-ESI-MS, 1D NMR, and 2D NMR). Compound 6 showed significant cytotoxic activity against A-549 and MG-63 cell lines with IC50 values of 6.96 and 1.73 μg/mL, respectively.

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A New Metabolite from the Endophytic Fungus Penicillium citrinum

Natural Product Communications ◽

10.1177/1934578x1300800510 ◽

2013 ◽

Vol 8 (5) ◽

pp. 1934578X1300800 ◽

Cited By ~ 1

Author(s):

Xinlan Li ◽

Liang Zhang ◽

Yanhui Liu ◽

Zhiyong Guo ◽

Zhangshuang Deng ◽

...

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Cell ◽

Endophytic Fungus ◽

Cancer Cell Lines ◽

Penicillium Citrinum ◽

Hep G2 ◽

Different Levels

A new polyketide, penicillocitrin A (1), together with four known compounds, was isolated from the endophytic fungus Penicillium citrinum (CTGU-TS-24) of Tapiscia sinensis Oliv., and their structures were elucidated by NMR spectroscopic and MS spectrums. The five compounds were evaluated cytotoxic activity to four cancer cell lines A549, Hep G2, Hela and Caski at different levels.

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