scholarly journals Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

2013 ◽  
Vol 65 ◽  
pp. 324-334 ◽  
Author(s):  
Jeriel T.R. Keeney ◽  
Sarah Förster ◽  
Rukhsana Sultana ◽  
Lawrence D. Brewer ◽  
Caitlin S. Latimer ◽  
...  
1980 ◽  
Vol 238 (2) ◽  
pp. G124-G130
Author(s):  
J. C. Barton ◽  
M. E. Conrad ◽  
L. Harrison ◽  
S. Nuby

A relationship between lead retention and vitamin D has been recognized for many years, but the reasons for this association remained unknown. In rats, the manipulation of dietary vitamin D content had no significant effect on the absorption of lead from isolated gut loops and parenteral vitamin D stimulation did not affect lead absorption in rachitic animals. In contrast, dietary vitamin D deficiency and repletion resulted in increased absorption in intact animals due to prolonged gastrointestinal transit time. Both dietary vitamin D deficiency and repletion were associated with decreased body retention of radiolead given intravenously. Further, single doses of parenteral vitamin D administered to animals previously given tracer radiolead resulted in a dose-related enhancement of lead excretion and changes in tissue lead content.


Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3528
Author(s):  
Maša Hribar ◽  
Hristo Hristov ◽  
Živa Lavriša ◽  
Barbara Koroušić Seljak ◽  
Matej Gregorič ◽  
...  

Vitamin D is involved in calcium and phosphorus metabolism, and is vital for numerous bodily functions. In the absence of sufficient UV-B light-induced skin biosynthesis, dietary intake becomes the most important source of vitamin D. In the absence of biosynthesis, the recommended dietary vitamin D intake is 10–20 µg/day. Major contributors to dietary vitamin D intake are the few foods naturally containing vitamin D (i.e., fish), enriched foods, and supplements. The present study aimed to estimate the vitamin D intake in Slovenia, to identify food groups that notably contribute to vitamin D intake, and to predict the effects of hypothetical mandatory milk fortification. This study was conducted using data collected by the national cross-sectional food consumption survey (SI.Menu) in adolescents (n = 468; 10–17 years), adults (n = 364; 18–64 years), and the elderly (n = 416; 65–74 years). Data collection was carried out between March 2017 and April 2018 using the EU Menu Methodology, which included two 24-hour recalls, and a food propensity questionnaire. Very low vitamin D intakes were found; many did not even meet the threshold for very low vitamin D intake (2.5 µg/day). Mean daily vitamin D intake was 2.7, 2.9, and 2.5 µg in adolescents, adults, and the elderly, respectively. Daily energy intake was found to be a significant predictor of vitamin D intake in all population groups. In adolescents and adults, sex was also found to be a significant predictor, with higher vitamin D intake in males. The study results explained the previously reported high prevalence of vitamin D deficiency in Slovenia. An efficient policy approach is required to address the risk of vitamin D deficiency, particularly in vulnerable populations.


BMJ ◽  
1989 ◽  
Vol 299 (6693) ◽  
pp. 236-237 ◽  
Author(s):  
A. H. Sultan ◽  
F. E. Bruckner ◽  
J. B. Eastwood

2007 ◽  
Vol 137 (2) ◽  
pp. 461-465 ◽  
Author(s):  
Hope A. Weiler ◽  
William D. Leslie ◽  
John Krahn ◽  
Pauline Wood Steiman ◽  
Colleen J. Metge

2021 ◽  
Vol 17 (1) ◽  
pp. 38-42
Author(s):  
I.V. Pankiv

In addition to the classic role of vitamin D in maintaining the normal state of the musculoskeletal system in the last decade, there is evidence that reduced serum concentrations of 25(OH)D are associated with a number of extraskeletal diseases (diabetes mellitus, hypertension, thyroid diseases, age-related cognitive decline, dysfunction of the immune and reproductive systems, etc.). Prevention of these diseases is achieved with significantly higher concentrations of 25(OH)D in the serum than those necessary to maintain normal bone tissue, regulate absorption and maintain calcium homeostasis. To ensure the concentration of the circulating form of vitamin D — 25(OH)D in the serum at a level that ensures optimal functioning, you need a higher consumption of this vitamin. Decreased blood concentration of vitamin D (< 30 ng/ml) is observed in 92 % of the adult population of Ukraine, regardless of the season. The causes of vitamin D deficiency are the low efficiency of its endogenous synthesis in the skin due to insufficient insolation and inadequate intake of this vitamin with food. Due to the half-life of vitamin D of about two months, periodic weekly or monthly intake of total doses of cholecalciferol provides the same values in the serum as daily intake. The review of the lite­rature considers the importance of vitamin D deficiency and deficiency in disorders of many systems of the human body and the development of various pathological conditions, which justifies the wider use of methods to correct the status of vitamin D. Despite the need for large-scale randomized clinical trials to determine the use of vitamin D, now there is no doubt that the normalization of the level of 25(OH)D in the serum is required at all age stages of ontogenesis.


2021 ◽  
Author(s):  
Federica Conte ◽  
Judith Okely ◽  
Olivia Hamilton ◽  
Janie Corley ◽  
Danielle Page ◽  
...  

Identifying predictors of cognitive decline within older age helps to understand its mechanisms and to identify those at greater risk. Here we examine how cognitive change from 11 to 70 years is associated with cognitive change within older age (70 to 82 years) in the Lothian Birth Cohort 1936 longitudinal study (N=1091 at recruitment). Using latent growth curve models, we estimate rates of change from age 70 to 82 in general cognitive ability (g) and in three cognitive domains: visuospatial, memory and processing speed. g accounted for 71.3% of interindividual change variance. Greater 11-70 cognitive gain predicted slower decline in g over 12 subsequent years (β = .163, p = .001), independently of cognitive level at age 70, and domain-specific change beyond g. These results contribute toward identifying people at higher risk of age-related cognitive decline. Age-related cognitive decline is a significant threat to the quality of life in older age. Its economic and social impact on society will increase together with the steadily rising life expectancy. How can we preserve cognitive health in older age? Researchers have made significant advances in identifying protective and risk factors. However, most studies focus on a limited age range, and cognitive change mechanisms are not yet completely understood. This work takes advantage of almost life-spanning longitudinal data to test if cognitive trajectory across childhood and adulthood can predict cognitive trajectories in older age. Our findings show that earlier change is associated with later change. Some factors related to individual differences in cognitive change might thus operate over much of the adult life course, and certainly before older age. This knowledge can help identify individuals at higher risk of decline and understand the mechanisms and factors responsible.


1990 ◽  
Vol 183 (4) ◽  
pp. 1303
Author(s):  
A. Loffreda ◽  
S. Vitagliano ◽  
V. de Novellis ◽  
C. Losasso ◽  
D. De Santis ◽  
...  

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