Effects of vitamin D on the absorption and retention of lead

1980 ◽  
Vol 238 (2) ◽  
pp. G124-G130
Author(s):  
J. C. Barton ◽  
M. E. Conrad ◽  
L. Harrison ◽  
S. Nuby

A relationship between lead retention and vitamin D has been recognized for many years, but the reasons for this association remained unknown. In rats, the manipulation of dietary vitamin D content had no significant effect on the absorption of lead from isolated gut loops and parenteral vitamin D stimulation did not affect lead absorption in rachitic animals. In contrast, dietary vitamin D deficiency and repletion resulted in increased absorption in intact animals due to prolonged gastrointestinal transit time. Both dietary vitamin D deficiency and repletion were associated with decreased body retention of radiolead given intravenously. Further, single doses of parenteral vitamin D administered to animals previously given tracer radiolead resulted in a dose-related enhancement of lead excretion and changes in tissue lead content.

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3528
Author(s):  
Maša Hribar ◽  
Hristo Hristov ◽  
Živa Lavriša ◽  
Barbara Koroušić Seljak ◽  
Matej Gregorič ◽  
...  

Vitamin D is involved in calcium and phosphorus metabolism, and is vital for numerous bodily functions. In the absence of sufficient UV-B light-induced skin biosynthesis, dietary intake becomes the most important source of vitamin D. In the absence of biosynthesis, the recommended dietary vitamin D intake is 10–20 µg/day. Major contributors to dietary vitamin D intake are the few foods naturally containing vitamin D (i.e., fish), enriched foods, and supplements. The present study aimed to estimate the vitamin D intake in Slovenia, to identify food groups that notably contribute to vitamin D intake, and to predict the effects of hypothetical mandatory milk fortification. This study was conducted using data collected by the national cross-sectional food consumption survey (SI.Menu) in adolescents (n = 468; 10–17 years), adults (n = 364; 18–64 years), and the elderly (n = 416; 65–74 years). Data collection was carried out between March 2017 and April 2018 using the EU Menu Methodology, which included two 24-hour recalls, and a food propensity questionnaire. Very low vitamin D intakes were found; many did not even meet the threshold for very low vitamin D intake (2.5 µg/day). Mean daily vitamin D intake was 2.7, 2.9, and 2.5 µg in adolescents, adults, and the elderly, respectively. Daily energy intake was found to be a significant predictor of vitamin D intake in all population groups. In adolescents and adults, sex was also found to be a significant predictor, with higher vitamin D intake in males. The study results explained the previously reported high prevalence of vitamin D deficiency in Slovenia. An efficient policy approach is required to address the risk of vitamin D deficiency, particularly in vulnerable populations.


BMJ ◽  
1989 ◽  
Vol 299 (6693) ◽  
pp. 236-237 ◽  
Author(s):  
A. H. Sultan ◽  
F. E. Bruckner ◽  
J. B. Eastwood

2007 ◽  
Vol 137 (2) ◽  
pp. 461-465 ◽  
Author(s):  
Hope A. Weiler ◽  
William D. Leslie ◽  
John Krahn ◽  
Pauline Wood Steiman ◽  
Colleen J. Metge

1990 ◽  
Vol 183 (4) ◽  
pp. 1303
Author(s):  
A. Loffreda ◽  
S. Vitagliano ◽  
V. de Novellis ◽  
C. Losasso ◽  
D. De Santis ◽  
...  

2020 ◽  
Vol 57 (6) ◽  
pp. 885-888
Author(s):  
Elise E. B. LaDouceur ◽  
Brian G. Murphy ◽  
Michael M. Garner ◽  
Andrew N. Cartoceti

Four captive, lesser hedgehog tenrecs ( Echinops telfairi) were euthanized for soft bones that prevented normal mastication and/or ambulation. Antemortem radiographs (available in 2 cases) revealed osteopenia. Antemortem bloodwork (available in 2 cases) revealed hypophosphatemia. Dietary history (available in 2 cases) indicated the animals were eating only insects. Histologically, all examined bones had wide osteoid seams that caused expansion of the cortices. Osteoid deposition was exuberant and it partially filled marrow cavities (hyperostosis). Nondecalcified sections of bone (available in 2 cases) revealed that osteoid was poorly mineralized, consistent with osteomalacia. Insects are poor dietary sources of vitamin D, and dietary vitamin D deficiency is considered the most likely cause for metabolic bone disease in these animals.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Honglin Dong ◽  
Viktorija Asmolovaite ◽  
Nareen Marseal ◽  
Maryam Mearbon

Purpose Vitamin D deficiency is prevalent worldwide. This paper aims to investigate the vitamin D status and dietary intake in young university students. Design/methodology/approach Forty-one healthy students aged 18–29 years from Coventry University UK were recruited during January-February 2019, including white Caucasians (n = 18), African-Caribbeans (n = 14) and Asians (n = 9). Plasma 25(OH)D concentrations were measured and dietary vitamin D intake was determined. Chi-square and simple linear regression were used to analyse the data. Findings The plasma 25(OH)D concentrations were (36.0 ± 22.2) nmol/L in all subjects, (46.5 ± 25.3) nmol/L in white Caucasians, (22.6 ± 7.4) nmol/L in African-Caribbeans and (37.4 ± 21.7 nmol/L) in Asians. The majority (85.7%) of African-Caribbeans were vitamin D deficient compared with 22.2% of white Caucasians and 33.3% of Asians (p = 0.001). Overweight/obese subjects showed a significant higher proportion of vitamin D deficiency (65%) than normal weight subjects (28.6%) (p = 0.04). The average dietary vitamin D intake in all subjects was (4.6 ± 3.9) µg/day. Only 12.1% of the subjects met the recommended dietary vitamin D intake of 10 µg/day. Dietary vitamin D intake (p = 0.04) and ethnicity (p = 0.01) were significant predictors of 25(OH)D levels and accounted for 13% and 18.5% of 25(OH)D variance, respectively. Research limitations/implications This small-scale study showed an alarmingly high prevalence of vitamin D deficiency among subjects from African-Caribbean origin during wintertime. Education programs and campaigns are urgently needed to fight the vitamin D deficiency in this population. Originality/value The targeted population were in a critical period of transition from adolescence toward adulthood involving in changes in behaviours and nutrition.


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