Myeloperoxidase-mediated oxidation of edaravone produces an apparent non-toxic free radical metabolite and modulates hydrogen peroxide-mediated cytotoxicity in HL-60 cells

2019 ◽  
Vol 143 ◽  
pp. 422-432 ◽  
Author(s):  
Lindsey Y.K. Suh ◽  
Dinesh Babu ◽  
Lusine Tonoyan ◽  
Béla Reiz ◽  
Randy Whittal ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Free Radical ◽  
Mediated Oxidation

scholarly journals RuIII(edta) mediated oxidation of azide in the presence of hydrogen peroxide. Azide versus peroxide activation

2014 ◽  
Vol 43 (8) ◽  
pp. 3087-3094 ◽  
Author(s):  
Debabrata Chatterjee ◽  
Alicja Franke ◽  
Maria Oszajca ◽  
Rudi van Eldik
Keyword(s):  
Hydrogen Peroxide ◽  
Peroxide Activation ◽  
Mediated Oxidation

Generation of free radical and hydrogen peroxide from 2-hydroxyemodin, a direct-acting mutagen, and dna strand breaks by active oxygen

1987 ◽  
Vol 37 (2) ◽  
pp. 149-156 ◽  
Author(s):  
M. Kodama ◽  
Y. Kamioka ◽  
T. Nakayama ◽  
C. Nagata ◽  
N. Morooka ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Free Radical ◽  
Dna Strand Breaks ◽  
Active Oxygen ◽  
Strand Breaks ◽  
Dna Strand ◽  
Direct Acting

scholarly journals Phytochemical screening and In-vitro antioxidant activity of Centella asiatica extracts

2017 ◽  
Vol 9 (4) ◽  
pp. 615
Author(s):  
Mukesh Kumar Yadav ◽  
Santosh Kumar Singh ◽  
JS Tripathi ◽  
YB Tripathi
Keyword(s):  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Centella Asiatica ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Phytochemical Screening

<p><em>Centella asiatica</em> also known as <em>mandukparni </em>or Indian pennywort or <em>jalbrahmi</em>, which has been used as a medicine in the Ayurveda from ancient times and mentioned in many classical texts of Ayurveda. <em>Centella asiatica</em> has long been used to improve memory and cognitive function.</p><p>The study aimed to identify the phytochemicals present in different solvent extracts of <em>Centella asiatica </em>(i.e. PECA- Petroleum ether extract of <em>C. asiatica, </em>CCA- Chloroform extract of <em>C. asiatica, </em>EACA- Ethyl acetate extract of <em>C. asiatica,</em> ECA- Ethanolic extract of <em>C. asiatica, </em>HACA- Hydro-alcoholic extract of <em>C. asiatica</em>)<em> </em>and evaluate the respective in-vitro antioxidant potentials. <em></em></p><p>The phytochemical screening of extracts was done with standardized procedures and the antioxidant potential of different solvent extracts of <em>Centella asiatica</em> was assessed by its free radical scavenging activity 2, 2-diphenyl -1- picrylhydrazyl (DPPH) as well as hydrogen peroxide scavenging assay respectively for reducing capability.</p><p>In all different solvent extracts of <em>C. asiatica</em> revealed excellent free radical scavenging activity as revealed by 2-2- diphenyl-1-picryl-hydrazyl (DPPH) assay with  EC<sub>50</sub> values for ECA=128.752±1.85 μg/ml, HACA=274.884±1.21 μg/ml and hydrogen peroxide assay against the standard (Butylated hydroxytoluene) BHT, with the EC<sub>50</sub> values ECA=429.69±0.92 μg/ml HACA=458.08±0.58 μg/ml while rest solvent extracts shown very less antioxidant activity.</p><p> The present study indicates that the <em>Centella asiatica</em> extracts have good antioxidant activity which can be used in stress and anxiety and also a good source to be used as natural drugs.</p>

Mechanism of Hydrogen Peroxide and Hydroxyl Free Radical–Induced Intracellular Acidification in Cultured Rat Cardiac Myoblasts

1996 ◽  
Vol 78 (4) ◽  
pp. 564-572 ◽  
Author(s):  
Mei-Lin Wu ◽  
Ke-Li Tsai ◽  
Seu-Mei Wang ◽  
Jiahn-Chun Wu ◽  
Bor-Sen Wang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Free Radical ◽  
Intracellular Acidification ◽  
Hydroxyl Free Radical ◽  
Cardiac Myoblasts

scholarly journals Auto-Cross-Linking Hydrogels of Hydrogen Peroxide-Oxidized Pectin and Gelatin for Applications in Controlled Drug Delivery

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Claudia A. Garrido ◽  
Michel Vargas ◽  
Jose F. Alvarez-Barreto
Keyword(s):  
Drug Delivery ◽  
Hydrogen Peroxide ◽  
Low Cost ◽  
Controlled Drug Delivery ◽  
Wound Dressings ◽  
Attractive Alternative ◽  
Swelling Properties ◽  
Degree Of Oxidation ◽  
Mediated Oxidation ◽  
Recent Attention

Pectin-based hydrogels for biomedical applications have attracted recent attention due to their low cost, large availability of the materials, and high levels of biocompatibility. Specifically, periodate-oxidized pectin has been combined with chitosan and gelatin to form different structures. However, hydrogen peroxide-mediated oxidation of pectin has not been studied for this application; furthermore, there is little information on the effect of the degree of oxidation on hydrogel characteristics nor has the feasibility of these systems as controlled drug delivery matrices been explored. Thus, the present work proposes to study the properties of gelatin-peroxide-oxidized pectin hydrogels as drug delivery systems in wound dressing applications. Combinations of pectin at different degrees of oxidation (high, low, and native pectin) and gelatin were analyzed and tested by swelling properties, reswelling from xerogel and aerogel forms, SEM, FTIR, and drug release. It was determined that hydrogels that contained oxidized pectin had improved swelling ratios and stability, at 32°C, compared to those with native pectin and only gelatin. The porosity of the oxidized pectin hydrogels allowed to have sustained and high release rates, which would make them an attractive alternative for wound dressings.

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