Pro- and anti-inflammatory cytokine expression in carp blood and head kidney leukocytes exposed to cyanotoxin stress – An in vitro study

2012 ◽  
Vol 33 (2) ◽  
pp. 382-388 ◽  
Author(s):  
Anna Rymuszka ◽  
Łukasz Adaszek
2013 ◽  
Vol 65 ◽  
pp. 128
Author(s):  
Ewa Obuchowicz ◽  
Anna M. Bielecka ◽  
Monika Paul-Samojedny ◽  
Marta Nowacka

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Dan Li ◽  
Chenyu Li ◽  
Yan Xu

Abstract Background and Aims Acute kidney injury (AKI), commonly appeared in cardiac arrest, surgery and kidney transplantation which involved in ischemia-reperfusion (IR) injury of kidney. However, the mechanisms underlying inflammatory response in IR AKI is still unclear. Method Public dataset showed kruppel-like factor 6 (KLF6) was significantly highly expressed (P<0.05) in AKI, implies KLF6 might be associated with AKI. To evaluate the mechanism of KLF6 on IR AKI, 30 rats were randomly divided into sham and IR group, and were sacrificed at 0 h, 3 h, 6 h, 12 h or 24 h after IR. Results The results showed KLF6 expression was peaking at 6 h after IR, and the expression of pro-inflammatory cytokines MCP-1 and TNF-α were increased both in serum and kidney tissues after IR, while anti-inflammatory cytokine IL-10 was decreased after IR. Furthermore, in vitro results showed KLF6 knock-down reduced the pro-inflammatory cytokines expression and increased the anti-inflammatory cytokines expression. Conclusion These results suggest that (1) KLF6 might be a novel biomarker for early diagnosis of AKI and (2) targeting KLF6 expression may offer novel strategies to protect kidneys from IR AKI Figure KLF6, AKI, Control Inflammation


2020 ◽  
Vol 14 ◽  
pp. 177-183
Author(s):  
Chang-Chin Wu ◽  
Yi-Ru Chen ◽  
Dai-Hua Lu ◽  
Li-Ho Hsu ◽  
Kai-Chiang Yang ◽  
...  

2018 ◽  
Vol 72 (9) ◽  
pp. 2171-2180 ◽  
Author(s):  
Zorica D. Petrović ◽  
Jelena Đorović ◽  
Dušica Simijonović ◽  
Snežana Trifunović ◽  
Vladimir P. Petrović

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