scholarly journals A meta-analysis of the relationship between antidepressant use in pregnancy and the risk of preterm birth and low birth weight

2014 ◽  
Vol 36 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Hsiang Huang ◽  
Shane Coleman ◽  
Jeffrey A. Bridge ◽  
Kimberly Yonkers ◽  
Wayne Katon
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Meta Analysis ◽  
Antidepressant Use ◽  
The Relationship ◽  
In Pregnancy

scholarly journals Associations between high temperatures in pregnancy and risk of preterm birth, low birth weight, and stillbirths: systematic review and meta-analysis

BMJ ◽  
2020 ◽  
pp. m3811
Author(s):  
Matthew Francis Chersich ◽  
Minh Duc Pham ◽  
Ashtyn Areal ◽  
Marjan Mosalam Haghighi ◽  
Albert Manyuchi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Random Effects ◽  
High Temperatures ◽  
Meta Analysis ◽  
Middle Income ◽  
Statistical Heterogeneity ◽  
In Pregnancy

Abstract Objective To assess whether exposure to high temperatures in pregnancy is associated with increased risk for preterm birth, low birth weight, and stillbirth. Design Systematic review and random effects meta-analysis. Data sources Medline and Web of Science searched up to September 2018, updated in August 2019. Eligibility criteria for selecting studies Clinical studies on associations between high environmental temperatures, and preterm birth, birth weight, and stillbirths. Results 14 880 records and 175 full text articles were screened. 70 studies were included, set in 27 countries, seven of which were countries with low or middle income. In 40 of 47 studies, preterm births were more common at higher than lower temperatures. Exposures were classified as heatwaves, 1°C increments, and temperature threshold cutoff points. In random effects meta-analysis, odds of a preterm birth rose 1.05-fold (95% confidence interval 1.03 to 1.07) per 1°C increase in temperature and 1.16-fold (1.10 to 1.23) during heatwaves. Higher temperature was associated with reduced birth weight in 18 of 28 studies, with considerable statistical heterogeneity. Eight studies on stillbirths all showed associations between temperature and stillbirth, with stillbirths increasing 1.05-fold (1.01 to 1.08) per 1°C rise in temperature. Associations between temperature and outcomes were largest among women in lower socioeconomic groups and at age extremes. The multiple temperature metrics and lag analyses limited comparison between studies and settings. Conclusions Although summary effect sizes are relatively small, heat exposures are common and the outcomes are important determinants of population health. Linkages between socioeconomic status and study outcomes suggest that risks might be largest in low and middle income countries. Temperature rises with global warming could have major implications for child health. Systematic review registration PROSPERO CRD 42019140136 and CRD 42018118113.

scholarly journals Low birth weight, preterm birth and small for gestational age association with adult depression: systematic review and meta-analysis

2014 ◽  
Vol 205 (5) ◽  
pp. 340-347 ◽  
Author(s):  
Christian Loret De Mola ◽  
Giovanny Vinícius Araújo De França ◽  
Luciana de Avila Quevedo ◽  
Bernardo Lessa Horta
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Premature Birth ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Adult Depression ◽  
Meta Analyses ◽  
Relationship Of ◽  
The Relationship

BackgroundThere is no consensus on the effects that low birth weight, premature birth and intrauterine growth have on later depression.AimsTo review systematically the evidence on the relationship of low birth weight, smallness for gestational age (SGA) and premature birth with adult depression.MethodWe searched the literature for original studies assessing the effect of low birth weight, premature birth and SGA on adult depression. Separate meta-analyses were carried out for each exposure using random and fixed effects models. We evaluated the contribution of methodological covariates to heterogeneity using meta-regression.ResultsWe identified 14 studies evaluating low birth weight, 9 premature birth and 4 SGA. Low birth weight increased the odds of depression (OR = 1.39, 95% CI 1.21–1.60). Premature birth and SGA were not associated with depression, but publication bias might have underestimated the effect of the former and only four studies evaluated SGA.ConclusionsLow birth weight was associated with depression. Future studies evaluating premature birth and SGA are needed.

Efficacy of additional psychosocial intervention in reducing low birth weight and preterm birth in teenage pregnancy: A systematic review and meta-analysis

2015 ◽  
Vol 44 ◽  
pp. 106-116 ◽  
Author(s):  
Kanokporn Sukhato ◽  
Chathaya Wongrathanandha ◽  
Ammarin Thakkinstian ◽  
Alan Dellow ◽  
Pornpot Horsuwansak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Psychosocial Intervention ◽  
Teenage Pregnancy ◽  
Meta Analysis

scholarly journals Relation of Hemoglobin Measured at Different Times in Pregnancy to Preterm Birth and Low Birth Weight in Shanghai, China

1998 ◽  
Vol 148 (10) ◽  
pp. 998-1006 ◽  
Author(s):  
L.-M. Zhou ◽  
W.-W. Yang ◽  
J.-Z. Hua ◽  
C.-Q. Deng ◽  
X. Tao ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
In Pregnancy

scholarly journals Effect of per Capita Income on the Relationship between Periodontal Disease during Pregnancy and the Risk of Preterm Birth and Low Birth Weight Newborn. Systematic Review and Meta-Analysis

2020 ◽  
Vol 17 (21) ◽  
pp. 8015
Author(s):  
Carmen Alba Moliner-Sánchez ◽  
José Enrique Iranzo-Cortés ◽  
José Manuel Almerich-Silla ◽  
Carlos Bellot-Arcís ◽  
José Carmelo Ortolá-Siscar ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Periodontal Disease ◽  
Pregnant Women ◽  
Capita Income ◽  
Meta Analysis ◽  
Income Level ◽  
Per Capita Income ◽  
Per Capita

This work analyzed the available evidence in the scientific literature about the risk of preterm birth and/or giving birth to low birth weight newborns in pregnant women with periodontal disease. A systematic search was carried out in three databases for observational cohort studies that related periodontal disease in pregnant women with the risk of preterm delivery and/or low birth weight, and that gave their results in relative risk (RR) values. Eleven articles were found, meeting the inclusion criteria. Statistically significant values were obtained regarding the risk of preterm birth in pregnant women with periodontitis (RR = 1.67 (1.17–2.38), 95% confidence interval (CI)), and low birth weight (RR = 2.53 (1.61–3.98) 95% CI). When a meta-regression was carried out to relate these results to the income level of each country, statistically significant results were also obtained; on the one hand, for preterm birth, a RR = 1.8 (1.43–2.27) 95% CI was obtained and, on the other hand, for low birth weight, RR = 2.9 (1.98–4.26) 95% CI. A statistically significant association of periodontitis, and the two childbirth complications studied was found, when studying the association between these results and the country’s per capita income level. However, more studies and clinical trials are needed in this regard to confirm the conclusions obtained.

scholarly journals Warning of Immortal Time Bias When Studying Drug Safety in Pregnancy: Application to Late Use of Antibiotics and Preterm Delivery

2020 ◽  
Vol 17 (18) ◽  
pp. 6465
Author(s):  
Giovanni Corrao ◽  
Federico Rea ◽  
Matteo Franchi ◽  
Benedetta Beccalli ◽  
Anna Locatelli ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Preterm Delivery ◽  
Apgar Score ◽  
Time Varying ◽  
Immortal Time Bias ◽  
Increased Risk ◽  
In Pregnancy

This study aimed to illustrate and account for immortal time bias in pregnancy observational investigations, using the relationship between late use of antibiotics and risk of preterm birth as an example. We conducted a population-based cohort study including 549,082 deliveries between 2007 and 2017 in Lombardy, Italy. We evaluated the risk of preterm births, low birth weight, small for gestational age, and low Apgar score associated with antibiotic dispensing during the third trimester of pregnancy. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) of the outcomes, considering the use of antibiotics as time-fixed (with biased classification of exposure person-time) and time-varying (with proper classification of exposure person-time) exposure. There were 23,638 (4.3%) premature deliveries. There was no association between time-fixed exposure to antibiotics and preterm delivery (adjusted HR 0.96; 95% CI 0.92 to 1.01) but an increased risk of preterm birth when time-varying exposure to antibiotics was considered (1.27; 1.21 to 1.34). The same trend was found for low birth weight and low Apgar score. Immortal time bias is a common and sneaky trap in observational studies involving exposure in late pregnancy. This bias could be easily avoided with suitable design and analysis.

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