Diabetic Polyneuropathy Relates to Bone Metabolism and Markers of Bone Turnover in Elderly Patients With Type 2 Diabetes: Greater Effects in Male Patients

2012 ◽  
Vol 9 (3) ◽  
pp. 187-196 ◽  
Author(s):  
Sazan Rasul ◽  
Aysegul Ilhan ◽  
Ludwig Wagner ◽  
Anton Luger ◽  
Alexandra Kautzky-Willer
Keyword(s):  
Type 2 Diabetes ◽  
Elderly Patients ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Diabetic Polyneuropathy ◽  
Markers Of Bone Turnover ◽  
Male Patients

scholarly journals Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Xin Zhao ◽  
Lili Huo ◽  
Xiaofeng Yu ◽  
Xiaomei Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Elderly Patients ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Elderly Male ◽  
Male Patients

Objective. This study is aimed at analyzing the association between bone metabolism indices and diabetic retinopathy (DR) in elderly patients with type 2 diabetes mellitus. Methods. Data of 352 men and 284 postmenopausal women, aged more than 50 years, with type 2 diabetes mellitus were retrospectively analyzed. Patients were divided into three groups based on the degree of DR: nondiabetic retinopathy (NDR) group, background diabetic retinopathy (BDR) group, and proliferative diabetic retinopathy (PDR) group. Results. (1) The diabetic duration and urinary albumin to creatinine ratio (UACR) were significantly higher in the PDR and BDR groups than in the NDR group ( P < 0.05 ). The level of beta-C-terminal telopeptide (β-CTX) in male patients was lower in the PDR and BDR groups than in the NDR group ( P < 0.05 ). In addition, the level of procollagen 1 intact N-terminal (P1NP) in female patients was higher in the PDR and BDR groups than in the NDR group ( P < 0.05 ). (2) For men and postmenopausal women, the proportion of vitamin deficiency was higher in the PDR and BDR groups than in the NDR group ( P < 0.05 ). (3) The logistic regression analysis in men and postmenopausal women showed that the diabetic duration and lower levels of UACR and 25(OH)D were independent risk factors for DR ( P < 0.05 ). (4) The diabetic duration was also an independent risk factor for PDR ( P < 0.05 ); however, no independent correlation was found between the level of 25(OH)D and PDR ( P > 0.05 ). Conclusions. A close association was observed between 25(OH)D level and DR in the elderly male patients and postmenopausal women with type 2 diabetes mellitus. P1NP and β-CTX levels might be closely related to DR in elderly male patients and postmenopausal women with type 2 diabetes mellitus.

Bone Markers (BMKs) and its Relation with Peripheral Neuropathy (PNP) in Type 2 Diabetic Patient (T2DM) in Basrah

2021 ◽  
Vol 19 (12) ◽  
pp. 50-54
Author(s):  
Shaimaa Sadiq Ahmed ◽  
Mustafa Abd Almajeed ◽  
Ali Abdulla AL Idani
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Bone Turnover ◽  
Diabetic Patient ◽  
Bone Metabolism ◽  
Diabetic Peripheral Neuropathy ◽  
Bone Markers ◽  
Markers Of Bone Turnover ◽  
Type 2 Diabetic

The aim of this study was to evaluate differences in bone metabolism by calculating markers of bone turnover (C-terminal telopeptide and osteocalcin) with type 2 diabetes and patients in diabetic peripheral neuropathy patients compared with those without diabetic peripheral neuropathy.

scholarly journals The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Wen-hua Xiao ◽  
Yan-rong Wang ◽  
Wen-fang Hou ◽  
Chao Xie ◽  
Hai-ning Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Fasting Blood Glucose ◽  
Serum Levels ◽  
Female Group ◽  
Markers Of Bone Turnover ◽  
Male Patients ◽  
Postmenopausal Female

Aim.To investigate whether pioglitazone had detrimental effects on biochemical markers of bone turnover in patients with type 2 diabetes (T2DM).Methods.Seventy patients with T2DM were included in this study. The patients remained on their previous antihyperglycemic therapies during the trial. Pioglitazone was then added on their regimen for 3 months.Results.After 3 months of treatment with pioglitazone, the levels of fasting blood glucose and HbA1cwere significantly decreased (7.9±1.5 mmol/L versus9.1±1.6 mmol/L and7.1±1.0%versus8.2±1.4%, resp.,P<0.01), compared with baseline in the overall patients. Serum concentrations of P1NP and BAP were significantly decreased from baseline (45.0±20.0 μg/L versus40.6±17.9 μg/L and13.23±4.7 μg/L versus12.3±5.0 μg/L, resp.,P<0.01) in female group, but not in male group. The serum levels of OC and CTX were unchanged in both female and male subgroups. In addition, the levels of serum BAP and P1NP were significantly decreased after pioglitazone treatment in postmenopausal subgroup, comparing with baseline.Conclusion.Pioglitazone inhibits bone formation and does not seem to affect bone resorption. Postmenopausal female patients rather than premenopausal or male patients are particularly vulnerable to this side effect of pioglitazone.

The effect of atorvastatin on markers of bone turnover in patients with type 2 diabetes

Bone ◽  
2004 ◽  
Vol 35 (3) ◽  
pp. 766-770 ◽  
Author(s):  
G.D. Braatvedt ◽  
W. Bagg ◽  
G. Gamble ◽  
J. Davidson ◽  
I.R. Reid
Keyword(s):  
Type 2 Diabetes ◽  
Bone Turnover ◽  
Markers Of Bone Turnover

scholarly journals Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease

2016 ◽  
Vol 174 (2) ◽  
pp. 115-124 ◽  
Author(s):  
Vikram V Shanbhogue ◽  
Stinus Hansen ◽  
Morten Frost ◽  
Niklas Rye Jørgensen ◽  
Anne Pernille Hermann ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Turnover ◽  
Cortical Bone ◽  
Biochemical Markers ◽  
Microvascular Disease ◽  
Cortical Porosity ◽  
Markers Of Bone Turnover

Objective and designPatients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectionalin vivostudy was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patients with and without diabetic microvascular disease (MVD+ and MVD− respectively) and to compare them with healthy controls.MethodsFifty-one T2D patients (MVD+ group:n=25) were recruited from Funen Diabetic Database and matched for age, sex and height with 51 healthy subjects. High-resolution peripheral quantitative tomography (HR-pQCT) was used to assess bone structure at the non-dominant distal radius and tibia. Estimated bone strength was calculated using finite element analysis. Biochemical markers of bone turnover were measured in all participants.ResultsAfter adjusting for BMI, MVD+ patients displayed lower cortical volumetric BMD (P=0.02) and cortical thickness (P=0.02) and higher cortical porosity at the radius (P=0.02) and a trend towards higher cortical porosity at the tibia (P=0.07) compared to controls. HR-pQCT parameters did not differ between MVD− and control subjects. Biochemical markers of bone turnover were significantly lower in MVD+ and MVD− patients compared to controls (allP<0.01). These were no significant correlations between disease duration, glycemic control (average glycated hemoglobin over the previous 3 years) and HR-pQCT parameters.ConclusionCortical bone deficits are not a characteristic of all T2D patients but of a subgroup characterized by the presence of microvascular complications. Whether this influences fracture rates in these patients needs further investigation.

scholarly journals Markers of Bone Turnover and 25-Hydroxy Vitamin D in Women with Type 2 Diabetes and Newly Diagnosed Osteoporosis

2016 ◽  
Vol 23 (1) ◽  
Author(s):  
Raluca Nan ◽  
Adrian Cursaru ◽  
Daniel Grigorie ◽  
Alina Şucaliuc ◽  
Ramona M. Drăguţ ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Bone Turnover ◽  
Newly Diagnosed ◽  
Markers Of Bone Turnover ◽  
25 Hydroxy Vitamin D

scholarly journals Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus

2021 ◽  
Vol 10 (10) ◽  
pp. 1337-1343
Author(s):  
Xiaoxia Jia ◽  
Yaxin An ◽  
Yuechao Xu ◽  
Yuxian Yang ◽  
Chang Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Fat Thickness ◽  
Turnover Markers ◽  
Perirenal Fat

Background Obesity is known as a common risk factor for osteoporosis and type 2 diabetes mellitus (T2DM). Perirenal fat, surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study aimed to explore the relationship between perirenal fat and bone metabolism in patients with T2DM. Methods A total of 234 patients with T2DM were recruited from September 2019 to December 2019 in the cross-sectional study. The biochemical parameters and bone turnover markers (BTMs) were determined in all participants. Perirenal fat thickness (PrFT) was performed by ultrasounds via a duplex Doppler apparatus. Associations between PrFT and bone metabolism index were determined via correlation analysis and regression models. Results The PrFT was significantly correlated with β-C-terminal telopeptides of type I collagen (β-CTX) (r = −0.14, P < 0.036), parathyroid hormone (iPTH) (r = −0.18, P ≤ 0.006), and 25 hydroxyvitamin D (25-OH-D) (r = −0.14, P = 0.001). Multivariate analysis confirmed that the association of PrFT and β-CTX (β = −0.136, P = 0.042) was independent of other variables. Conclusion This study showed a negative and independent association between PrFT and β-CTX in subjects with T2DM, suggesting a possible role of PrFT in bone metabolism. Follow-up studies and further research are necessary to validate the associations and to elucidate the underlying mechanisms.

scholarly journals Bone mineral density and bone metabolism in postmenopausal women with type 2 diabetes in a Chinese community: a cross-sectional study

2020 ◽  
Author(s):  
Wu Han ◽  
Yufan Zhang ◽  
Wenbin Zhou ◽  
Jing Dai ◽  
Tao Yao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Osteoporosis Fracture

Abstract AMI: There is growing evidence of a complex interaction between T2DM and osteoporosis. The purpose of this study was to further study the relationship between BTMs and fasting blood glucose (FBG) in postmenopausal patients with type 2 diabetes and to analyze the effect of hyperglycemia on bone metabolism. Methods: Six hundred and twelve (612) postmenopausal women were included, including one hundred and seven (107) subjects with T2DM and five hundred and five (505) subjects without diabetes. BMD was measured by DXA (dual-energy X-ray absorptiometry). Markers of bone formation (P1NP) and resorption ( CTX ) were quantified. Results: Compared to controls, postmenopausal women with diabetes had a higher prevalence of previous osteoporosis fracture (27.1% vs. 17.4% for diabetic and nondiabetic women, respectively) and a higher BMD. The P1NP level in women with T2DM was 49.451 ng/ml, while in N-DM individuals, it was 58.633 ng/ml, (p = 0.017). The CTX level in women with T2DM was 0.325 ng/ml, while in N-DM individuals, it was 0.412 ng/ml (p=0.039). In addition, P1NP was significantly negatively associated with age (β=-0.590; p= 0.002) and FBG (β=-1.950; p = 0.035). CTX was negatively associated with FBG (β=-0.029; p = 0.015). Conclusions: T2DM was associated with higher BMD and paradoxically, with an increased risk of fracture. Postmenopausal women with T2DM had lower bone turnover than controls. With increased levels of FBG, bone formation and bone resorption were reduced, and the overall bone turnover level was reduced. Keywords Type 2 diabetes mellitus · Bone mineral density · Bone turnover markers · Osteoporosis fracture

scholarly journals Bone mineral density and bone metabolism in postmenopausal women with type 2 diabetes in a Chinese community: a cross-sectional study

2020 ◽  
Author(s):  
Wu Han ◽  
Yufan Zhang ◽  
Wenbin Zhou ◽  
Guolong Zhang ◽  
Jindi Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Negatively Associated

Abstract Background: There is growing evidence of a complex interaction between type 2 diabetes (T2DM) and osteoporosis. The purpose of this study was to further study the relationship between Bone turnover markers (BTMs) and fasting blood glucose (FBG) in postmenopausal patients with type 2 diabetes and to analyze the effect of hyperglycemia on bone metabolism.Methods: Six hundred and twelve (612) postmenopausal women were included, including one hundred and seven (107) subjects with T2DM and five hundred and five (505) subjects without diabetes. Bone mineral density (BMD) was measured by DXA (dual-energy X-ray absorptiometry). Markers of bone formation Type 1 collagen N-terminal peptide (P1NP) and resorption C-telopeptide of type l collagen (CTX) were quantified.Results: Compared to controls, postmenopausal women with diabetes had a higher prevalence of previous osteoporosis fracture (27.1% vs. 17.4% for diabetic and nondiabetic women, respectively) and a higher BMD. The P1NP level in women with T2DM was 49.451 ng/ml, while in N-DM individuals, it was 58.633 ng/ml, (p = 0.017). The CTX level in women with T2DM was 0.325 ng/ml, while in N-DM individuals, it was 0.412 ng/ml (p=0.039). In addition, P1NP was significantly negatively associated with age (β=-0.590; p= 0.002) and FBG (β=-1.950; p = 0.035). CTX was negatively associated with FBG (β=-0.029; p = 0.015).Conclusions: T2DM was associated with higher BMD and paradoxically, with an increased risk of fracture. Postmenopausal women with T2DM had lower bone turnover than controls. With increased levels of FBG, bone formation and bone resorption were reduced, and the overall bone turnover level was reduced.

Sign in / Sign up

Export Citation Format

Share Document