Association of APOA1 gene polymorphisms (G-75A and C + 83 T) with deep vein thrombosis: An Indian study

Gene Reports ◽  
2021 ◽  
pp. 101304
Author(s):  
Vinay Kumar ◽  
Chhavi Rai ◽  
Babita Kumari ◽  
Swati Srivastava ◽  
UdayYanamandra ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Gene Polymorphisms ◽  
Vein Thrombosis ◽  
Apoa1 Gene ◽  
Indian Study ◽  
Deep Vein

Thrombophilic risk factors are laterally associated with Apolipoprotein E gene polymorphisms in deep vein thrombosis patients: An Indian study

2018 ◽  
Vol 34 (5) ◽  
pp. 324-335
Author(s):  
Pulkit Rastogi ◽  
Narender Kumar ◽  
Jasmina Ahluwalia ◽  
Reena Das ◽  
Neelam Varma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Deep Vein Thrombosis ◽  
Gene Polymorphisms ◽  
Apoe Gene ◽  
Therapeutic Implications ◽  
Vein Thrombosis ◽  
Apolipoprotein E Gene ◽  
Polymerase Chain ◽  
Apoe Genotypes ◽  
Deep Vein

Introduction Deep vein thrombosis is a multifactorial disease with many acquired and genetic risk factors. Polymorphism in the APOE gene is an upcoming potential pathogenic factor whose role is unclear in deep vein thrombosis. Methods An equal number of deep vein thrombosis cases and controls (N = 100, each) were investigated for APOE gene polymorphisms along with known acquired and hereditable thrombophilic risk factors. APOE genotyping was done by polymerase chain reaction. Results The ε3/ε4 and ε2/ε3 APOE genotypes were commoner in deep vein thrombosis cases than controls but not statistically significant ( ε3/ε4 → 18% versus 11%, OR = 1.776, CI = 0.792–3.984, p = 0.16; ε2/ε3 →10% versus 9%, OR = 1.123, CI = 0.436–2.895, p = 0.809). However, the following risk factors were found to be laterally associated with APOE genotypes in cases of deep vein thrombosis: pregnancy with ε2/ε3 genotype positivity (N = 29; p = 0.019), recurrent pregnancy loss with ε3/ε3 genotype (N = 29; p = 0.016), normal antithrombin levels with ε3/ε3 genotype (N = 62; p = 0.03) and non-O blood group with ε3/ε4 genotype (N = 100; p = 0.023). Conclusion APOE genotypes have shown only a modest association with deep vein thrombosis and were not statistically significant. A lateral association of these genotypes with thrombophilic risk factors was observed which may be investigated further for the possible pathogenetic mechanisms and their therapeutic implications.

The nitric oxide synthase 3 gene polymorphisms and their association with deep vein thrombosis in Asian Indian patients

2010 ◽  
Vol 411 (9-10) ◽  
pp. 649-652 ◽  
Author(s):  
Mohd. Suhail Akhter ◽  
Arijit Biswas ◽  
Ravi Ranjan ◽  
Amit Sharma ◽  
Sunil Kumar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Deep Vein Thrombosis ◽  
Nitric Oxide Synthase ◽  
Asian Indian ◽  
Gene Polymorphisms ◽  
Vein Thrombosis ◽  
Indian Patients ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase ◽  
Deep Vein

Association between estrogen receptor alpha and beta gene polymorphisms and deep vein thrombosis

2007 ◽  
Vol 120 (5) ◽  
pp. 639-645 ◽  
Author(s):  
Aline Morandi Aléssio ◽  
Nelci Fenalti Höehr ◽  
Lúcia Helena Siqueira ◽  
Margareth Castro Ozelo ◽  
Antônio de Pádua Mansur ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Deep Vein Thrombosis ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Beta Gene

scholarly journals Endothelial Nitric Oxyde Synthase Gene Polymorphisms in a Tunisian Deep Vein Thrombosis Group

2016 ◽  
Vol 04 (09) ◽  
pp. 33-41 ◽  
Author(s):  
Nedra Grira ◽  
Nadia Ben Abdelhafidh ◽  
Manel Ayoub ◽  
Rihab Sendesni ◽  
Bochra Adib ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Gene Polymorphisms ◽  
Vein Thrombosis ◽  
Deep Vein

Diagnostic potential of circulating micro RNA hsa-miR-320 in patients of high altitude induced deep vein thrombosis: An Indian study

Gene Reports ◽  
2019 ◽  
Vol 17 ◽  
pp. 100550
Author(s):  
Swati Srivastava ◽  
Iti Garg ◽  
Babita Kumari ◽  
Chhavi Rai ◽  
Yamini Singh ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
High Altitude ◽  
Micro Rna ◽  
Vein Thrombosis ◽  
Indian Study ◽  
Diagnostic Potential ◽  
Deep Vein

Feasibility Study of Catheter-directed Thrombolysis with Recombinant Staphylokinase in Deep Venous Thrombosis

1998 ◽  
Vol 79 (03) ◽  
pp. 517-519 ◽  
Author(s):  
Stephane Heymans ◽  
Raymond Verhaeghe ◽  
Luc Stockx ◽  
Désiré Collen
Keyword(s):  
Deep Vein Thrombosis ◽  
Continuous Infusion ◽  
High Speed ◽  
Minor Bleeding ◽  
Vein Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
Long Term Follow Up ◽  
Valve Function ◽  
Rotating Impeller ◽  
Deep Vein

SummaryThe feasibility of catheter-directed thrombolysis with recombinant staphylokinase was evaluated in six selected patients with deep vein thrombosis. The patients underwent intrathrombus infusion of recombinant staphylokinase (2 mg bolus followed by a continuous infusion of 1 mg/h). Heparin was given via the catheter as a bolus (5000 U) and as a continuous infusion (1000 U/h). Complete lyis was obtained in five patients and partial lysis in one patient. Complications consisted of minor bleeding in four subjects. Symptomatic reocclusion occurred in one. Debulking of the thrombus mass by a high speed rotating impeller (n = 1) and stenting (n = 3) were used as additional interventions. An underlying anatomical abnormality was present in two patients. Long term follow up revealed normal patency in all patients and normal valve function in four patients. Symptomatic venous insufficiency with valve dysfunction was present in the two with a second thrombotic episode.Thus catheter-directed infusion of recombinant staphylokinase in patients with deep vein thrombosis appears feasible and may be associated with a high frequency of thrombolysis. Larger studies to define the clinical benefit of this treatment appear to be warranted.

Deep Vein Thrombosis and Fibrinolysis

1991 ◽  
Vol 66 (04) ◽  
pp. 426-429 ◽  
Author(s):  
Marcel Levi ◽  
Anthonie W A Lensing ◽  
Harry R Büller ◽  
Paolo Prandoni ◽  
Gerard Dooijewaard ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Tissue Type ◽  
Controlled Study ◽  
First Episode ◽  
Control Group ◽  
Vein Thrombosis ◽  
Type Plasminogen Activator ◽  
Deep Vein

SummaryIn the present study 57 consecutive patients with a first episode of venographically proven deep vein thrombosis were investigated to evaluate the release of tissue-type plasminogen activator (t-PA) and of urokinase-type plasminogen activator (u-PA) in response to DDAVP stimulation as well as the resting plasminogen activator inhibitor (PAI) concentration, comparing this to the results obtained in 66 similar patients with a clinical suspicion of thrombosis but with a normal venogram. All assays were performed without knowledge of the patient's status.Four patients in the deep vein thrombosis-group (7%) had an absent u-PA antigen response upon DDAVP infusion, while a normal response was observed in all control subjects. Patients and controls showed similar increases in t-PA antigen level upon DDAVP. High resting PAI antigen levels were encountered in 5 patients in the deep vein thrombosis-group (9%) and in 6 subjects in the control group (9%).The results from this controlled study indicate that a defective release of u-PA may occur in patients with deep vein thrombosis and may have pathogenetic significance. Furthermore it is concluded that elevation of PAI levels cannot be considered as a specific risk factor for venous thrombosis.

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