Endothelin-1 is potent endothelium derived as the strongest vasoconstrictor that has 21 amino acids and damage of endothelial layer activated the increasing of vasoconstriction, the increasing of endothelin-1 caused a resistence across the maternal vascular system that has endothelial layer make hypertension. This research aims is to determine te difference levels of endothelin-1 in primigravida pregnancy and multigravida pregnancy. The design type of this research was cross sectional study. There were 44 popltions, 22 mothers with primigravida pregnancy and 22 mothers with multigravida pregnancy respectively. The samples were selected using consecutive sampling technique. The instrument ofthis research was laboratory test. The result of this research were tested by Mann Whitney and Kruskal Wallis tests.The results indicate that the average of Endothelin-1 in primigravida pregnant mothers (91.02 ng / L), multigravida pregnancy’s parity ≤3 (89.04 ng / L), the Multigravida pregnancy’s parity >3 (62.13 ng / L) with p=0.367>0.05which means there is no difference of endothelin-1 between primigravida pregnancy and multigravida pregnancy.
Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study of rural Bangladeshi women
