scholarly journals Tu1150 A FOLLOW-UP STUDY OF ENDOSCOPIC RADIOFREQUENCY ABLATION IN TREATING EARLY ESOPHAGEAL SQUAMOUS CELL NEOPLASIA∼LESSONS FROM PATHOLOGICAL ANALYSIS OF RECURRENT LESIONS

2018 ◽  
Vol 87 (6) ◽  
pp. AB542-AB543
Author(s):  
Wen-Lun Wang ◽  
Ching-Tai Lee ◽  
Ming-Hung Hsu ◽  
Chi-Ming Tai ◽  
Hsiu-Po Wang
Keyword(s):  
Radiofrequency Ablation ◽  
Squamous Cell ◽  
Pathological Analysis ◽  
Follow Up Study ◽  
Endoscopic Radiofrequency Ablation

Lessons from pathological analysis of recurrent early esophageal squamous cell neoplasia after complete endoscopic radiofrequency ablation

Endoscopy ◽  
2018 ◽  
Vol 50 (08) ◽  
pp. 743-750 ◽  
Author(s):  
Wen-Lun Wang ◽  
I-Wei Chang ◽  
Chien-Chuan Chen ◽  
Chi-Yang Chang ◽  
Cheng-Hao Tseng ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Local Recurrence ◽  
Endoscopic Resection ◽  
Squamous Cell ◽  
Complete Response ◽  
Primary Treatment ◽  
Long Term Follow Up ◽  
Endoscopic Radiofrequency Ablation ◽  
Lost To Follow Up

Abstract Background Endoscopic radiofrequency ablation (RFA) is a treatment option for early esophageal squamous cell neoplasia (ESCN); however, long-term follow-up studies are lacking. The risks of local recurrence and “buried cancer” are also uncertain. Methods Patients with flat-type ESCN who were treated with balloon-type ± focal-type RFA were consecutively enrolled. Follow-up endoscopy was performed at 1, 3, and 6 months, and then every 6 months thereafter. Endoscopic resection was performed for persistent and recurrent ESCN, and the histopathology of resected specimens was assessed. Results A total of 35 patients were treated with RFA, of whom 30 (86 %) achieved a complete response, three were lost to follow-up, and five (14 %) developed post-RFA stenosis. Two patients had persistent ESCN and received further endoscopic resection, in which the resected specimens all revealed superficial submucosal invasive cancer. Six of the 30 patients with successful RFA (20 %) developed a total of seven episodes of local recurrence (mean size 1.4 cm) during the follow-up period (mean 40.1 months), all of which were successfully resected endoscopically without adverse events. Histological analysis of the resected specimens revealed that six (86 %) had esophageal glandular ductal involvement, all of which extended deeper than the muscularis mucosae layer. Immunohistochemistry staining for P53 and Ki67 suggested a clonal relationship between the ductal involvement and epithelial cells. None of the tumors extended out of the ductal structure; no cases of cancer buried beneath the normal neosquamous epithelium were found. Conclusions Because ductal involvement is not uncommon and may be related to recurrence, the use of RFA should be conservative and may not be the preferred primary treatment for early ESCN.

scholarly journals Radiofrequency Ablation for Early Superficial Flat Esophageal Squamous Cell Neoplasia: A Comprehensive Review

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Siyu Lei ◽  
Sachin Mulmi Shrestha ◽  
Ruihua Shi
Keyword(s):  
Radiofrequency Ablation ◽  
Early Detection ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Epithelium ◽  
Current Evidence ◽  
Eastern Asia ◽  
Comprehensive Review ◽  
Neoplastic Lesions ◽  
Endoscopic Radiofrequency Ablation

Esophageal squamous cell carcinoma comprises the majority of esophageal carcinoma in the Eastern Asia. The need of early detection of precancerous neoplastic lesions and cancer has been necessitated due to the probability of progression to the advanced stage and its poor prognosis. In recent times, many endoscopic modalities have come into practice for early detection and treatment. Endoscopic radiofrequency ablation (RFA) has been recommended as an efficient therapy in treating the dysplastic mucosa in Barrett’s esophagus (BE). Its potential in reversing neoplastic lesions in squamous epithelium has been gradually explored. This article is aimed at reviewing the current evidence regarding the use of RFA on esophageal squamous cell neoplasia.

scholarly journals Outcomes from a prospective trial of endoscopic radiofrequency ablation of early squamous cell neoplasia of the esophagus

2011 ◽  
Vol 74 (6) ◽  
pp. 1181-1190 ◽  
Author(s):  
Jacques J.G.H.M. Bergman ◽  
Yue-Ming Zhang ◽  
Shun He ◽  
Bas Weusten ◽  
Liyan Xue ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Squamous Cell ◽  
Prospective Trial ◽  
Endoscopic Radiofrequency Ablation

Medical Image Analysis Based on Endoscopic Radiofrequency Ablation Catheter System on the Treatment of Gastroesophageal Reflux Disease Related Extra-Esophageal Symptoms

2019 ◽  
Vol 9 (8) ◽  
pp. 1765-1769
Author(s):  
Wei-Tao Liang ◽  
Tao Li ◽  
Ji-Min Wu ◽  
Zhi-Wei Hu ◽  
Chao Yan ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Statistical Significance ◽  
Medical Image Analysis ◽  
Final Analysis ◽  
Symptom Scores ◽  
Endoscopic Radiofrequency Ablation

Objective: Gastroesophageal reflux disease is easily missed on X-ray or even computer tomography. This study was to evaluate the endoscopic imaging for the radiofrequency ablation (RA) on the diagnosis and management of gastroesophageal reflux disease related extra-esophageal symptoms. Methods: From January 2011, to January 2012, we allocated 51 patients to LTF and 47 to RA procedure. Primary outcome measures, including symptom scores of globus hysterics, chest pain, belching, hiccup, cough and asthma as well as proton pump inhibitors (PPIs) use, were analyzed after 5-year follow-up. Results: There were 90 patients following RA procedure (N = 40) or LTF (N = 50) that completed the designated 5-year follow-up and were included in the final analysis. At the end of 5-year follow-up, the symptom scores were all significantly decreased as compared with the corresponding values before the two procedures in both groups (p < 0.05). Moreover, the improvement in symptom scores between the two groups did not achieve statistical significance. After RA procedure and LTF, 18 (45%) and 32 (64%) patients in each group achieved complete PPIs therapy independence (p = 0.071). Comparing with LTF, however, the RA procedure had a higher risk of reoperation (17.5% vs. 0, p = 0.002). Conclusion: Comparing with LTF in controlling GERD-related extra-esophageal symptoms, RA procedure can offer equivalent relief on symptoms and PPIs independence. However, it has a higher risk of reoperation during the 5 years follow-up.

Balloon-based, circumferential, endoscopic radiofrequency ablation of Barrett's esophagus: 1-year follow-up of 100 patients (with video)

2007 ◽  
Vol 65 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Virender K. Sharma ◽  
Kenneth K. Wang ◽  
Bergein F. Overholt ◽  
Charles J. Lightdale ◽  
M. Brian Fennerty ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Endoscopic Radiofrequency Ablation
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