scholarly journals Evaluation of antioxidant activities, toxicity studies and the DNA damage protective effect of various solvent extracts of Litsea cubeba fruits

Heliyon ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e03637
Author(s):  
Tapan Seal ◽  
Kausik Chaudhuri ◽  
Basundhara Pillai ◽  
Shrabana Chakrabarti ◽  
Tanmoy Mondal ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protective Effect ◽  
Antioxidant Activities ◽  
Toxicity Studies ◽  
Litsea Cubeba ◽  
Dna Damage Protective

scholarly journals Beneficial effects of mycophenolate mofetil on cardiotoxicity induced by tacrolimus in wistar rats

2016 ◽  
Vol 242 (4) ◽  
pp. 448-455 ◽  
Author(s):  
Hanen Ferjani ◽  
Rim Timoumi ◽  
Ines Amara ◽  
Salwa Abid ◽  
Abedellatif Achour ◽  
...  
Keyword(s):  
Dna Damage ◽  
Mycophenolate Mofetil ◽  
Oral Administration ◽  
Protective Effect ◽  
Cardiac Toxicity ◽  
De Novo ◽  
Antioxidant Activities ◽  
Solid Organ Transplantation ◽  
Protein Carbonyl ◽  
Solid Organ

The immunosuppressive drug tacrolimus (TAC) is used clinically to reduce the rejection rate in transplant patients. TAC has contributed to an increased prevalence of cardiovascular disease in patients receiving solid organ transplantation. Mycophenolate mofetil (MMF), a potent inhibitor of de novo purine synthesis, is known to prevent ongoing rejection in combination with TAC. In the present study, we investigated the antioxidant and antigenotoxic effect of MMF on TAC-induced cardiotoxicity in rats. Oral administration of TAC at 2.4, 24, and 60 mg/kg b.w. corresponding, respectively, to 1, 10, and 25% of LD50 for 24 h caused cardiac toxicity in a dose-dependant manner. TAC increased significantly DNA damage level in hearts of treated rats. Furthermore, it increased malondialdehyde (MDA) and protein carbonyl (PC) levels and decreased catalase (CAT) and superoxide dismutase (SOD) activities. The oral administration of MMF at 50 mg/kg b.w. simultaneously with TAC at 60 mg/kg b.w. proved a significant cardiac protection by decreasing DNA damage, MDA, and PC levels, and by increasing the antioxidant activities of CAT and SOD. Thus, our study showed, for the first time, the protective effect of MMF against cardiac toxicity induced by TAC. This protective effect was mediated via an antioxidant process.

Main nutrients, phenolics, antioxidant activity, DNA damage protective effect and microstructure of Sphallerocarpus gracilis root at different harvest time

2011 ◽  
Vol 127 (2) ◽  
pp. 615-622 ◽  
Author(s):  
Chun-yan Gao ◽  
Yue-hong Lu ◽  
Cheng-rui Tian ◽  
Jian-guo Xu ◽  
Xiao-peng Guo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Protective Effect ◽  
Harvest Time ◽  
Dna Damage Protective

scholarly journals DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster

2016 ◽  
Vol 39 (3) ◽  
pp. 431-441 ◽  
Author(s):  
Robson Alves da Silva ◽  
Rafael Rodrigues Dihl ◽  
Lucas Pinheiro Dias ◽  
Maiane Papke Costa ◽  
Bianca Regina Ribas de Abreu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drosophila Melanogaster ◽  
Protective Effect ◽  
Cashew Apple ◽  
Dna Damage Protective

Sulfated Polysaccharides from Tunisian Fish Skins: Antioxidant, DNA Damage Protective Effect and Antihypertensive Activities

2016 ◽  
Vol 24 (2) ◽  
pp. 166-175 ◽  
Author(s):  
Fatma Krichen ◽  
Wafa Karaoud ◽  
Nadhem Sayari ◽  
Assaâd Sila ◽  
Fatma Kallel ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protective Effect ◽  
Sulfated Polysaccharides ◽  
Dna Damage Protective

scholarly journals Nutritional profiles, phenolics, and DNA damage protective effect of Lycopus lucidus Turcz. root at different harvest times

2017 ◽  
Vol 20 (sup3) ◽  
pp. S3062-S3077
Author(s):  
Yue-hong Lu ◽  
Cheng-rui Tian ◽  
Chun-yan Gao ◽  
Run-guang Zhang ◽  
Qi Guo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protective Effect ◽  
Dna Damage Protective ◽  
Nutritional Profiles ◽  
Lycopus Lucidus
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