scholarly journals Mesenchymal stem cells act as stimulators of neurogenesis and synaptic function in a rat model of Alzheimer's disease

Heliyon ◽  
2021 ◽  
pp. e07996
Author(s):  
Maryam Doshmanziari ◽  
Sadegh Shirian ◽  
Mohammad-Reza Kouchakian ◽  
Seyedeh Farzaneh Moniri ◽  
Saranaz Jangnoo ◽  
...  
IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S478
Author(s):  
Maria Florencia Zappa Villar ◽  
Juliette Lopez Hanotte ◽  
Joaquin Pardo ◽  
Gustavo Ramon Morel ◽  
Mariana Gabriela Garcia ◽  
...  

2016 ◽  
Vol 11 (7) ◽  
pp. 629-646 ◽  
Author(s):  
Shubham Misra ◽  
Kanwaljit Chopra ◽  
Uma Nahar Saikia ◽  
Vivek Ranjan Sinha ◽  
Rakesh Sehgal ◽  
...  

2021 ◽  
Author(s):  
Mohamed Hosney ◽  
Alaa Sakraan ◽  
Aman Asaad ◽  
Mervat El-Deftar ◽  
Emad Elzayat

Abstract Alzheimer's disease (AD) is the most prevalent type of dementia characterized by its progression, neurobehavioral and neuro-pathological characteristics, leading to a diverse neuronal loss. Adipose-derived mesenchymal stem cells (ADMSCs) have previously proved potential role in preventing the pathogenesis of several neurodegenerative disorders, so regarded as a promising new approach for AD regenerative therapy. Taurine was found to enhance stem cell activation and propagation yielding a higher concentration of neural progenitors and stem cells, and aid to lessen the number of activated microglia leading to down-regulated inflammation in vitro. The present study aimed to investigate the possible therapeutic potential of ADMSCs and/or taurine in treating AD rat model. It was planned to include three successive phases; induction, withdrawal, and therapeutic phases. Fifty male Wistar rats were divided into 2 main groups: control (C) group and AD model group. Behavioral changes, as manifested by the T-Maze experiment, had been recorded. β-amyloid levels had been measured in brain homogenate and serum by ELISA. Oxidative stress marker (MDA), and anti-oxidant enzymes activity (SOD, GSH, and CAT) in brain, as well as serum acetylcholine esterase activity were spectrophotometrically determined. Pro-apoptotic (p53 and Bax) and anti-apoptotic (Bcl2) gene expression in brain were evaluated using RT-qPCR. The histopathological alterations in brain tissues were also observed. The present study proved the potential therapeutic ability of ADMSCs and/or taurine in alleviating the adverse pathological changes induced by AlCl3 in AD rat model at both physiological and molecular levels.


2019 ◽  
Vol 34 (4) ◽  
pp. 1131-1143 ◽  
Author(s):  
Ebrahim Nasiri ◽  
Akram Alizadeh ◽  
Amaneh Mohammadi Roushandeh ◽  
Rouhollah Gazor ◽  
Nasrin Hashemi-Firouzi ◽  
...  

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