Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer's disease

2016 ◽  
Vol 11 (7) ◽  
pp. 629-646 ◽  
Author(s):  
Shubham Misra ◽  
Kanwaljit Chopra ◽  
Uma Nahar Saikia ◽  
Vivek Ranjan Sinha ◽  
Rakesh Sehgal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Model Of Alzheimer’S Disease

scholarly journals Modulation of microglia and presynaptic protein expression after mesenchymal stem cells treatment in a rat model of Alzheimer's disease

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S478
Author(s):  
Maria Florencia Zappa Villar ◽  
Juliette Lopez Hanotte ◽  
Joaquin Pardo ◽  
Gustavo Ramon Morel ◽  
Mariana Gabriela Garcia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Protein Expression ◽  
Rat Model ◽  
Model Of Alzheimer’S Disease ◽  
Presynaptic Protein

Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer's disease

2020 ◽  
Vol 108 ◽  
pp. 101804
Author(s):  
Mahdi Ramezani ◽  
Alireza Komaki ◽  
Nasrin Hashemi-Firouzi ◽  
Keywan Mortezaee ◽  
Nafiseh Faraji ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Therapeutic Effects ◽  
Model Of Alzheimer’S Disease ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Mesenchymal stem cells act as stimulators of neurogenesis and synaptic function in a rat model of Alzheimer's disease

Heliyon ◽  
2021 ◽  
pp. e07996
Author(s):  
Maryam Doshmanziari ◽  
Sadegh Shirian ◽  
Mohammad-Reza Kouchakian ◽  
Seyedeh Farzaneh Moniri ◽  
Saranaz Jangnoo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Synaptic Function ◽  
Model Of Alzheimer’S Disease

Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cells (Admscs) and/or Taurine in Aluminum Chloride-Induced Alzheimer's Disease Rat Model

2021 ◽  
Author(s):  
Mohamed Hosney ◽  
Alaa Sakraan ◽  
Aman Asaad ◽  
Mervat El-Deftar ◽  
Emad Elzayat
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Cell Activation ◽  
Therapeutic Potential ◽  
Brain Homogenate ◽  
Oxidative Stress Marker

Abstract Alzheimer's disease (AD) is the most prevalent type of dementia characterized by its progression, neurobehavioral and neuro-pathological characteristics, leading to a diverse neuronal loss. Adipose-derived mesenchymal stem cells (ADMSCs) have previously proved potential role in preventing the pathogenesis of several neurodegenerative disorders, so regarded as a promising new approach for AD regenerative therapy. Taurine was found to enhance stem cell activation and propagation yielding a higher concentration of neural progenitors and stem cells, and aid to lessen the number of activated microglia leading to down-regulated inflammation in vitro. The present study aimed to investigate the possible therapeutic potential of ADMSCs and/or taurine in treating AD rat model. It was planned to include three successive phases; induction, withdrawal, and therapeutic phases. Fifty male Wistar rats were divided into 2 main groups: control (C) group and AD model group. Behavioral changes, as manifested by the T-Maze experiment, had been recorded. β-amyloid levels had been measured in brain homogenate and serum by ELISA. Oxidative stress marker (MDA), and anti-oxidant enzymes activity (SOD, GSH, and CAT) in brain, as well as serum acetylcholine esterase activity were spectrophotometrically determined. Pro-apoptotic (p53 and Bax) and anti-apoptotic (Bcl2) gene expression in brain were evaluated using RT-qPCR. The histopathological alterations in brain tissues were also observed. The present study proved the potential therapeutic ability of ADMSCs and/or taurine in alleviating the adverse pathological changes induced by AlCl3 in AD rat model at both physiological and molecular levels.

Melatonin-pretreated adipose-derived mesenchymal stem cells efficeintly improved learning, memory, and cognition in an animal model of Alzheimer's disease

2019 ◽  
Vol 34 (4) ◽  
pp. 1131-1143 ◽  
Author(s):  
Ebrahim Nasiri ◽  
Akram Alizadeh ◽  
Amaneh Mohammadi Roushandeh ◽  
Rouhollah Gazor ◽  
Nasrin Hashemi-Firouzi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Animal Model ◽  
Mesenchymal Stem Cells ◽  
Model Of Alzheimer’S Disease ◽  
Improved Learning

P1-312: Improved efficacy of mesenchymal stem cells by co-administration with galantamine in a tau hyperphophorylated model of Alzheimer's disease in rats

2015 ◽  
Vol 11 (7S_Part_10) ◽  
pp. P476-P476
Author(s):  
Shubham Misra ◽  
Kanwaljit Chopra ◽  
Uma Nahar Saikia ◽  
Bikash Medhi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Model Of Alzheimer’S Disease

scholarly journals Evaluation of Aβ Deposits in the Hippocampus of a Rat Model of Alzheimer’s Disease After Intravenous Injection of Human Adipose Derived Stem Cells by Immuno- and Thioflavin S-Costaining

Thrita ◽  
2019 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Doshmanziari ◽  
Arash Sarveazad ◽  
Fatemeh Moradi ◽  
Marjan Shariatpanahi ◽  
Esfandiar Doshmanziari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Intravenous Injection ◽  
Rat Model ◽  
Adipose Derived Stem Cells ◽  
Model Of Alzheimer’S Disease

scholarly journals The Effect of Intracerebroventricular Administration of Streptozocin on Cell Proliferation in Subventricular Zone Stem Cells in a Rat Model of Alzheimer’s Disease

2015 ◽  
Vol 3 (4) ◽  
pp. 80-86 ◽  
Author(s):  
Hoda Pasand Mozhdeh ◽  
Bahman Zeynali ◽  
Hadi Aligholi ◽  
Iraj Kashani Radgerdi ◽  
Sajad Sahab Negah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Rat Model ◽  
Subventricular Zone ◽  
Intracerebroventricular Administration ◽  
Model Of Alzheimer’S Disease

Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer’s Disease

2022 ◽  
Author(s):  
Henrique C. Campos ◽  
Deidiane Elisa Ribeiro ◽  
Debora Hashiguchi ◽  
Deborah Y. Hukuda ◽  
Christiane Gimenes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Transgenic Model ◽  
Model Of Alzheimer’S Disease
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