scholarly journals Is the sum greater than the whole? Association of heart risk factors and echocardiographic parameters with reduction in 6-minute walk test in stage A heart failure

2015 ◽  
Vol 24 ◽  
pp. S210
Author(s):  
M. Nolan ◽  
Y. Wang ◽  
H. Yang ◽  
T. Marwick
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Walk Test ◽  
Echocardiographic Parameters ◽  
6 Minute Walk Test ◽  
Minute Walk

Abstract 15403: Is the Sum Greater Than the Whole? Association of Heart Risk Factors and Echocardiographic Parameters With Reduction in 6-Minute Walk Test in Stage A Heart Failure

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mark T Nolan ◽  
Ying Wang ◽  
Hilda Yang ◽  
Thomas H Marwick
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Walk Test ◽  
Prior Chemotherapy ◽  
6Mwt Distance ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
6 Minute Walk Test ◽  
Minute Walk

Introduction: Chemotherapy increases long-term risk of heart failure (HF), but its impact relative to other HF risk factors is unknown. 6 minute walk test (6MWT) provides prognostic information regarding hospitalization and mortality in HF patients. We sought the relative role of these factors on echocardiographic changes and 6MWT. Hypothesis: Prior chemotherapy is associated with greater functional impairment than other stage A HF risk factors. Methods: We recruited 521 asymptomatic pts from the community aged ¬>65 years with stage A heart failure (SAHF, based on at least one of: diabetes, obesity, hypertension, coronary artery disease or chemotherapy). All went echocardiographic studies and 6MWT. 45 patients had previous chemotherapy (mean interval 7±7.5 years) and underwent 6MWT. These patients were matched 2:1 using demographic and clinical characteristics with patients who did not receive chemotherapy. Fisher’s test and independent t-test were used for statistical analysis. Results: There were no significant difference in demographic variables. The chemotherapy group had a significantly lower 6MWT distance (mean difference -155m) and significantly higher proportion of patients with 6MWT distance < 400m (26.7% vs. 11%, p=0.043). There were no significant difference in other echocardiographic parameters assessing systolic, diastolic and geometrical parameters. Conclusion: Prior chemotherapy has a significant long-term effect on functional capacity in comparison with other SAHF factors. As no one echo parameter was associated with this difference, this could potentially be secondary to noncardiac (including vascular) parameters.

Direct Myocardial Implantation of Human Fetal Stem Cells in Heart Failure Patients: Long-term Results

2010 ◽  
Vol 13 (1) ◽  
pp. 31 ◽  
Author(s):  
Federico Benetti ◽  
Ernesto Pe�herrera ◽  
Teodoro Maldonado ◽  
Yan Duarte Vera ◽  
Valvanur Subramanian ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Cardiac Function ◽  
Nyha Class ◽  
Left Ventricular ◽  
Long Term Results ◽  
Walk Test ◽  
The Mean ◽  
6 Minute Walk Test ◽  
Minute Walk

Background: End-stage heart failure (HF) is refractory to current standard medical therapy, and the number of donor hearts is insufficient to meet the demand for transplantation. Recent studies suggest autologous stem cell therapy may regenerate cardiomyocytes, stimulate neovascularization, and improve cardiac function and clinical status. Although human fetal-derived stem cells (HFDSCs) have been studied for the treatment of a variety of conditions, no clinical studies have been reported to date on their use in treating HF. We sought to determine the efficacy and safety of HFDSC treatment in HF patients.Methods and Results: Direct myocardial transplantation of HFDSCs by open-chest surgical procedure was performed in 10 patients with HF due to nonischemic, nonchagasic dilated cardiomyopathy. Before and after the procedure, and with no changes in their preoperative doses of medications (digoxin, furosemide, spironolactone, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, betablockers), patients were assessed for New York Heart Association (NYHA) class, performance in the exercise tolerance test (ETT), ejection fraction (EF), left ventricular end-diastolic dimension (LVEDD) via transthoracic echocardiography, performance in the 6-minute walk test, and performance in the Minnesota congestive HF test. All 10 patients survived the operation. One patient had a stroke 3 days after the procedure, and although she later recovered, she was unable to perform the follow-up tests. Another male patient experienced pericardial effusion 3 weeks after the procedure. Although it resolved spontaneously, the patient abandoned his control tests and died 5 months after the procedure. An autopsy of the myocardium suggested that new young cells were present in the cardiomyocyte mix. At 40 months, the mean (SD) NYHA class decreased from 3.4 0.5 to 1.33 0.5 (P = .001); the mean EF increased 31%, from 26.6% 4% to 34.8% 7.2% (P = .005); and the mean ETT increased 291.3%, from 4.25 minutes to 16.63 minutes (128.9% increase in metabolic equivalents, from 2.46 to 5.63) (P < .0001); the mean LVEDD decreased 15%, from 6.85 0.6 cm to 5.80 0.58 cm (P < .001); mean performance in the 6-minute walk test increased by 43.2%, from 251 113.1 seconds to 360 0 seconds (P = .01); the mean distance increased 64.4%, from 284.4 144.9 m to 468.2 89.8 m (P = .004); and the mean result in the Minnesota test decreased from 71 27.3 to 6 5.9 (P < .001).Conclusion: Although these initial findings suggest direct myocardial implantation of HFDSCs is feasible and improves cardiac function in HF patients at 40 months, more clinical research is required to confirm these observations.

scholarly journals Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure

2017 ◽  
Vol 240 ◽  
pp. 285-290 ◽  
Author(s):  
Nicole H.M.K. Uszko-Lencer ◽  
Rafael Mesquita ◽  
Eefje Janssen ◽  
Christ Werter ◽  
Hans-Peter Brunner-La Rocca ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Construct Validity ◽  
Test Performance ◽  
Walk Test ◽  
6 Minute Walk Test ◽  
Minute Walk

Utility of 6-Minute Walk Test to Predict Response to Cardiac Resynchronization Therapy in Patients With Mild Heart Failure

2020 ◽  
Vol 132 ◽  
pp. 79-86
Author(s):  
Spencer Z. Rosero ◽  
Natalia Hernandez ◽  
Ilan Goldenberg ◽  
Scott McNitt ◽  
Bronislava Plonsky ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Resynchronization Therapy ◽  
Cardiac Resynchronization ◽  
Walk Test ◽  
Resynchronization Therapy ◽  
Mild Heart Failure ◽  
6 Minute Walk Test ◽  
Minute Walk

The Utility of the 6-Minute Walk Test as a Measure of Frailty in Older Adults with Heart Failure

2008 ◽  
Vol 17 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Rebecca S. Boxer ◽  
Zhu Wang ◽  
Stephen J. Walsh ◽  
David Hager ◽  
Anne M. Kenny
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Walk Test ◽  
6 Minute Walk Test ◽  
Minute Walk
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