scholarly journals 023 Risk Stratification Using CHA2DS2-VASc and CHADS2 Scores in Patients With Chronic Atherosclerotic Cardiovascular Disease Receiving Aspirin With or Without Rivaroxaban: An Analysis of the COMPASS Trial

2020 ◽  
Vol 29 ◽  
pp. S48
Author(s):  
J. Sen ◽  
A. Tonkin ◽  
J. Varigos ◽  
S. Fonguh ◽  
S. Berkowitz ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Stratification ◽  
Atherosclerotic Cardiovascular Disease

Abstract P019: A Single Model For Predicting Major Adverse Cardiovascular Events In Individuals With And Without History Of Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk In Communities (aric) Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Yejin Mok ◽  
Lena Mathews ◽  
Ron C Hoogeveen ◽  
Michael J Blaha ◽  
Christie M Ballantyne ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Risk Stratification ◽  
Cardiovascular Events ◽  
Major Adverse Cardiovascular Events ◽  
Atherosclerotic Cardiovascular Disease ◽  
Single Model ◽  
History Of ◽  
Very High

Background: In the 2018 AHA/ACC Cholesterol guideline, risk stratification is an essential element. The use of a Pooled Cohort Equation (PCE) is recommended for individuals without atherosclerotic cardiovascular disease (ASCVD), and the new dichotomous classification of very high-risk vs. high-risk has been introduced for patients with ASCVD. These distinct risk stratification systems mainly rely on traditional risk factors, raising the possibility that a single model can predict major adverse cardiovascular events (MACEs) in persons with and without ASCVD. Methods: We studied 11,335 ARIC participants with (n=885) and without (n=10,450) a history of ASCVD (myocardial infarction, ischemic stroke, and symptomatic peripheral artery disease) at baseline (1996-98). We modeled factors in the PCE and the new classification for ASCVD patients (Figure legend) in a single CVD prediction model. We examined their associations with MACEs (myocardial infarction, stroke, and heart failure) using Cox models and evaluated the discrimination and calibration for a single model including those factors. Results: During a median follow-up of 18.4 years, there were 3,658 MACEs (3,105 in participants without ASCVD). In general, the factors in the PCE and the risk classification system for ASCVD patients were associated similarly with MACEs regardless of baseline ASCVD status, although age and systolic blood pressure showed significant interactions. A single model with these predictors and the relevant interaction terms showed good calibration and discrimination for those with and without ASCVD (c-statistic=0.729 and 0.704, respectively) (Figure). Conclusion: A single CVD prediction model performed well in persons with and without ASCVD. This approach will provide a specific predicted risk to ASCVD patients (instead of dichotomy of very high vs. high risk) and eliminate a practice gap between primary vs. secondary prevention due to different risk prediction tools.

Associations Among Daily Fish Intake, Monocyte/HDL-C Ratio, and Lifestyle in Japanese Males Aged >50: Risk Stratification of Atherosclerotic Cardiovascular Disease

2021 ◽  
Author(s):  
Shigemasa Tani ◽  
Wataru Atsumi ◽  
Kazuhiro Imatake ◽  
Yasuyuki Suzuki ◽  
Tsukasa Yagi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Stratification ◽  
Inflammatory Marker ◽  
Health Planning ◽  
Smoking Habit ◽  
Fish Intake ◽  
University Hospital ◽  
Atherosclerotic Cardiovascular Disease ◽  
Lifestyle Behaviors ◽  
Clinical Trial Registration

Abstract Background: The monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) may be a novel inflammatory marker of the developing atherosclerotic cardiovascular disease (ASCVD). We investigated the relationship between the average number of days of fish intake per week and the MHR and lifestyle behaviors and to explore the validity of stratifying the risk of ASCVD using the combination of MHR and the serum HDL-C level.Methods: This cross-sectional study was conducted in a population of 2485 males aged over 50 years at the Health Planning Center of Nihon University Hospital between April 2018 and March 2019.Results: The average frequency of fish intake was 2.32 ± 1.31 per week. Multiple stepwise regression analysis identified increased weekly fish frequency intake as an independent determinant of a decreased MHR (β = -0.072, p < 0.0001). Healthier lifestyle behaviors were also significantly associated with decreased MHR. As the fish intake frequency increased, the proportion of subjects with the cigarette smoking habit decreased (p = 0.014), that of subjects with aerobic exercise habit increased (p < 0.0001), and that of subjects with alcohol drinking habit increased (p < 0.0001). A risk stratification or ASCVD by combining the HDL-C level and fish intake frequency with the MHR could be developed, indicating that even with similar HDL-C levels, higher HMR and fish frequency are associated with higher risk ASCVD. Conclusion: A high fish intake frequency may be associated with healthier lifestyle behaviors as well as a lower MHR, and may thus represent a component of a healthy lifestyle associated with a lower risk of ASCVD in Japanese males aged over 50 years. These associations may be related to being the preventive effect of fish intake on ASCVD.Clinical Trial Registration: UMIN (http://www.umin.ac.jp/) Study ID: UMIN 000041368 registered 10/08/2020

CAC for Risk Stratification Among Individuals With Hypertriglyceridemia Free of Clinical Atherosclerotic Cardiovascular Disease

2021 ◽  
Author(s):  
Miguel Cainzos-Achirica ◽  
Renato Quispe ◽  
Ramzi Dudum ◽  
Philip Greenland ◽  
Donald Lloyd-Jones ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Stratification ◽  
Atherosclerotic Cardiovascular Disease

scholarly journals Risk stratification of atherosclerotic cardiovascular disease in Chinese adults

2016 ◽  
Vol 2 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Xue-Li Yang ◽  
Ji-Chun Chen ◽  
Jian-Xin Li ◽  
Jie Cao ◽  
Xiang-Feng Lu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Stratification ◽  
Atherosclerotic Cardiovascular Disease ◽  
Chinese Adults

scholarly journals Consensus statement for the management of dyslipidemia and hypertension in the Indian population with diabetes

2019 ◽  
Vol 6 (2) ◽  
pp. 562
Author(s):  
Jayagopal P. B. ◽  
M. Srinivas Rao ◽  
R. Vijaykumar ◽  
Soumitra Kumar ◽  
Girish Parthan
Keyword(s):  
Cardiovascular Disease ◽  
Risk Stratification ◽  
Blood Cholesterol ◽  
Risk Category ◽  
Multidisciplinary Teams ◽  
Extensive Literature ◽  
Atherosclerotic Cardiovascular Disease ◽  
Simultaneous Treatment ◽  
Treatment Targets ◽  
Patients With Diabetes

The mortality rate from cardiovascular disease (CVD) in India is higher than the global figures (272 per 100,000 persons vs. 235 per 100,000 persons, respectively). Smoking, obesity, hypertension, diabetes and dyslipidemia are the known risk factors for atherosclerotic cardiovascular disease (ASCVD). The treatment of either condition aims to reduce the risk of ASCVD. This goal is achievable only when a holistic, simultaneous treatment is initiated and is monitored to reduce the blood glucose, blood cholesterol, and BP. India heralds a huge population of nearly 73 million people with diabetes. Diabetes is one of the major contributors of ASCVD, dyslipidemia and hypertension often coexist with diabetes. Patients diagnosed with either condition need risk stratification, followed by defining the treatment target for each risk category and developing appropriate treatment strategies based on the risk category. Unfortunately, there is no clear guideline that defines the treatment targets and subsequent management. This statement has been created based on the vast experience and an extensive literature review conducted by experts from multidisciplinary teams to address several treatment dilemmas that are routinely faced by clinicians when treating their patients with diabetes. An attempt is made to provide well-defined answers to these quandaries. This statement discusses screening, diagnosis, risk stratification, treatment targets, and management of dyslipidemia and/or hypertension in patients with diabetes and provides a roadmap for the treatment of Indian patients to curtail the risk of ASCVD.

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