scholarly journals Laparoscopic partial sleeve duodenectomy for duodenal gist

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S599
Author(s):  
J. Broecker ◽  
D. Asbun ◽  
J. Stauffer
Keyword(s):  
Duodenal Gist

ASO Author Reflections: Proposed Algorithm for Surgical Treatment of Localized Duodenal GIST

2021 ◽  
Author(s):  
Frederiek Nuytens ◽  
Charles Honoré ◽  
Clément Dubois ◽  
Guillaume Piessen
Keyword(s):  
Surgical Treatment ◽  
Duodenal Gist

scholarly journals Safety of Regular-Dose Imatinib Therapy in Patients with Gastrointestinal Stromal Tumors Undergoing Dialysis

2016 ◽  
Vol 10 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Ryota Niikura ◽  
Takako Serizawa ◽  
Atsuo Yamada ◽  
Shuntaro Yoshida ◽  
Mariko Tanaka ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Imatinib Treatment ◽  
Efficacy And Safety ◽  
Tarry Stool ◽  
Dialysis Patients ◽  
Stromal Tumors ◽  
Duodenal Gist ◽  
Johnson Syndrome ◽  
Old Japanese ◽  
Steven Johnson Syndrome

The number of cancer patients undergoing dialysis has been increasing, and the number of these patients on chemotherapy is also increasing. Imatinib is an effective and safe therapy for KIT-positive gastrointestinal stromal tumors (GIST), but the efficacy and safety of imatinib in dialysis patients remain unclear. Because clinical trials have not been conducted in this population, more investigations are required. We report on a 75-year-old Japanese man undergoing dialysis who presented with massive tarry stool from a duodenal GIST. The duodenal GIST was 14 cm in diameter with multiple liver and bone metastases. The patient underwent an urgent pancreaticoduodenectomy to achieve hemostasis. After surgery, he was administered imatinib 400 mg/day. No severe adverse event including myelosuppression, congestive heart failure, liver functional impairment, intestinal pneumonia, or Steven-Johnson syndrome occurred, and the liver metastasis remained stable for 4 months. During chemotherapy, hemodialysis continued three times per week without adverse events. We suggest that regular-dose imatinib is an effective and safe treatment in patients with GIST undergoing dialysis. In addition, we present a literature review of the effectiveness and safety of imatinib treatment in dialysis patients.

scholarly journals Neoadjuvant treatment of a duodenal GIST revealed a new imatinib-sensitive exon 11 c-KIT-mutation

2016 ◽  
Vol 27 ◽  
pp. iv100
Author(s):  
V. Perfetti ◽  
S. Delfanti ◽  
L. Pugliese ◽  
R. Riboni ◽  
E. Dallera ◽  
...  
Keyword(s):  
Neoadjuvant Treatment ◽  
Kit Mutation ◽  
Duodenal Gist ◽  
Exon 11

scholarly journals Local Resection by Combined Laparoendoscopic Surgery for Duodenal Gastrointestinal Stromal Tumor

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Motohiko Kato ◽  
Kiyokazu Nakajima ◽  
Toshirou Nishida ◽  
Makoto Yamasaki ◽  
Tsutomu Nishida ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Postoperative Hemorrhage ◽  
Minimal Invasive ◽  
Local Resection ◽  
Gi Tract ◽  
Duodenal Gist ◽  
Attractive Option ◽  
Laparoscopic Assistance ◽  
Duodenal Resection ◽  
Dissection Technique

Combined laparoendoscopic surgery is a novel surgical method which consists of both endoscopic surgery from inside the gastrointestinal tract and laparoscopic surgery from the outside. We report a case of duodenal GIST, in which combined laparoendoscopic local resection was attempted. The lesion was resected endoscopically using endoscopic submucosal dissection technique under laparoscopic assistance. Laparoscope was used for originating the orientation of the tumor, intra-operative EUS, and monitoring serosal injury from the peritoneal cavity. Postoperative hemorrhage occurred; however, precise orientation of the lesion helped us to manage the patient with minimal invasive reoperation. And thus, the bowel integrity was completely preserved, by avoiding segmental duodenal resection and pancreaticoduodenectomy. This novel, less invasive surgical procedure may become an attractive option for the lesions originating in the anatomically challenging portion of the GI tract for endoscopic or laparoscopic surgery alone.

Duodenal GIST Masquerading as Pancreatic Head Mass in a Patient with Von Recklinghausenʼs Disease- Case Report

2016 ◽  
Vol 111 ◽  
pp. S972-S973
Author(s):  
Abhishek Bhurwal ◽  
Gaurav Sharma ◽  
Lawrence Rosenthal ◽  
Ronald Chamberlain
Keyword(s):  
Case Report ◽  
Pancreatic Head ◽  
Duodenal Gist ◽  
Disease Case

The clinicopathologic features and optimal surgical treatment of duodenal gastrointestinal tumor.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 519-519
Author(s):  
Seungjae Lee ◽  
Ki Byung Song
Keyword(s):  
Multivariate Analysis ◽  
Surgical Treatment ◽  
Surgical Resection ◽  
Tumor Size ◽  
Disease Free Survival ◽  
Mitotic Count ◽  
Perioperative Outcomes ◽  
Survival Outcomes ◽  
Clinicopathologic Features ◽  
Duodenal Gist

519 Background: Because of unclear clinicopathologic features, the optimal surgical procedure for duodenal gastrointestinal stromal tumor (GIST) remains poorly defined. We analyze clinicopathological features and recommend optimal surgical treatment of duodenal GIST. Methods: From July, 2000 to April 2017, 118 patients who had localized duodenal GIST were treated by curative surgical resection at a single institution. We retrospectively reviewed the clinicopathological characteristics and survival outcomes. Results: In survival analysis of all patients, 5-year overall survival (OS) and disease-free survival (DFS) rate were 94.9 and 79.2%, respectively. 19 patients developed recurrent disease at a median of 26.1 months from surgery and most common recurrence site was liver (63.2%). In multivariate analysis, mitotic count was the statistically significant prognostic factors of DFS. Our 20 cases of duodenal GIST in 1st or 4th portion were completely resected by limited resection(LR), regardless of tumor size. 98 patients with GISTs in 2nd or 3rd portion of duodenum underwent LR (n = 53) or pancreaticoduodenectomy (PD) (n = 45). Patients in the LR group had a smaller median tumor size (4.0 vs 5.3 cm, p = 0.026), more antimesenteric-sided location (41 vs 7cases, p < 0.001), less late complications (1 vs 7 cases, p = 0.014) and no postoperative newly developed diabetes mellitus (0 vs 4 cases, p = 0.027) than those in the PD group. When 53 patients in LR group further divided into minimal invasive LR (MILR) (n = 12) and open-LR (n = 41), MILR group had shorter operation time (155.0 vs 218.8 minutes, p = 0.013) and postoperative hospital stay (12.0 vs 19.4 days, p = 0.036). Conclusions: Patients with duodenal GIST who underwent complete surgical resection have favorable survival outcomes. Predictor of disease recurrence at multivariate analysis was mitotic count. LR is feasible and effective surgical treatment for the patients with small-sized, and anti-mesenteric sided duodenal GIST in terms of long-term oncologic outcomes and quality of life. MILR has better perioperative outcomes than open LR. Therefore, we should consider MILR as optimal surgical treatment for the selected patients with duodenal GIST.

scholarly journals Neoadjuvant Chemotherapy for Duodenal GIST: A Case Report

2017 ◽  
Vol 102 (1-2) ◽  
pp. 81-86
Author(s):  
Akiyoshi Seshimo ◽  
Masayoshi Tsuchiya ◽  
Yoshinobu Ueda ◽  
Makiko Kasuga ◽  
Mikiko Taneichi ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Hepatic Cirrhosis ◽  
Unknown Origin ◽  
Outer Side ◽  
Hepatitis C Infection ◽  
Complete Excision ◽  
Kit Mutation ◽  
Stromal Tumors ◽  
Duodenal Gist ◽  
Exon 11

The principal treatment for gastrointestinal stromal tumors (GISTs) is surgical; and complete excision is important, but cannot always be achieved. For such cases, neoadjuvant chemotherapy (NAC) with imatinib mesylate (IM) has been recommended. A case of a GIST of the second portion of the duodenum for which pancreatoduodenectomy was indicated, and for which partial resection was made possible as a result of cytoreduction by IM NAC, is reported. A 64-year-old man with pancytopenia due to hepatic cirrhosis caused by hepatitis C infection received repeated blood transfusions because of anemia of unknown origin starting 2 years earlier. Most recently, the patient had melena with hemoglobin of 5.1 mg/dL. Diagnostic imaging showed a solid tumor, 55 × 48 × 65 mm3, in the second portion of the duodenum showing mainly extramural development. Endoscopic aspiration biopsy showed proliferation of KIT-positive spindle-shaped heterotypic cells. GIST was diagnosed, and an exon 11 KIT mutation was found. Because of the exon 11 mutation, neoadjuvant IM was started at 400 mg/day and then eventually maintained at 300 mg/day for 10 months. Regular CT examinations showed gradual tumor shrinkage. At surgery, a tumor with strong extramural growth was found on the outer side of the duodenum that invaded the retroperitoneum. The tumor was excised as a mass, and the duodenum was resected partially. There has been no recurrence at 9 years postoperatively. Evaluating KIT exon mutations and predicting the effectiveness of NAC appear useful for determining the treatment policy for advanced GISTs.

scholarly journals Limited Wedge Resection of a Duodenal Gist in a Patient with Intermittent Melena

2021 ◽  
Keyword(s):  
Wedge Resection ◽  
Gi Bleeding ◽  
Gi Tract ◽  
Epigastric Discomfort ◽  
Stromal Tumors ◽  
Upper Gi ◽  
Duodenal Gist ◽  
Upper Gi Endoscopy ◽  
Subepithelial Lesion ◽  
Unexplained Symptoms

Gastrointestinal Stromal Tumors account for 1% - 2% of all gastrointestinal (GI) tract tumors. Among GISTs, duodenal localization occurs in less than 5% and usually presents with upper GI bleeding. A 45-year-old man presented in the outpatient department with complaints of epigastric discomfort, intermittent melena and undocumented weight loss for the preceding 3 months. Initial upper GI endoscopy showed mild duodenitis and no other upper GI pathology. For unexplained symptoms, a CT Scan was performed which demonstrated a well-defined solid lesion along the second part of the duodenum. An endoscopic ultrasound (EUS)-guided biopsy of a subepithelial lesion at D2 was performed. Immunohistochemistry findings were suggestive of GIST. Wedge resection of the duodenal mass was done. Duodenal GIST should be considered as a differential in cases of GI bleeding when other differentials have been ruled out. Limited resection of duodenal GIST should be considered over pancreaticoduodenectomy, in case of small size tumors.

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