Association of nitric oxide synthase 2(NOS2G-954C) polymorphism with cardiomyopathy in Trypanosoma cruzi infection

2005 ◽  
Vol 66 (8) ◽  
pp. 68
Author(s):  
Mercedes T. Fernandez-Mestre ◽  
Eva Salazar ◽  
Zulay E. Layrisse
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase ◽  
Cruzi Infection

Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase

1997 ◽  
Vol 6 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Huan Huang, MD ◽  
John Chan, MD ◽  
Murray Wittner, MD, PhD ◽  
Louis M Weiss, MD, MPH ◽  
J Bacchi, PhD ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Oxide Synthase ◽  
Cruzi Infection

Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice

2018 ◽  
Vol 129 ◽  
pp. 227-236 ◽  
Author(s):  
Amanda A. Felizardo ◽  
Ivo S. Caldas ◽  
Andréa A.S. Mendonça ◽  
Reggiani V. Gonçalves ◽  
Fernanda L. Tana ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Oxide Synthase ◽  
Cruzi Infection ◽  
Expression And Activity

scholarly journals Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytes

2008 ◽  
Vol 10 (14-15) ◽  
pp. 1558-1566 ◽  
Author(s):  
Fabiana S. Machado ◽  
Janeusa T. Souto ◽  
Marcos A. Rossi ◽  
Lisia Esper ◽  
Herbert B. Tanowitz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Cardiac Myocytes ◽  
Chemokine Production ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Placental Trypanosoma cruzi infection is restricted by nitric oxide production by endothetial nitric oxide synthase isoform

Placenta ◽  
2017 ◽  
Vol 51 ◽  
pp. 116-117
Author(s):  
M.F. Triquell ◽  
E. Benizio ◽  
M.J. Moreira-Espinoza ◽  
J.C. Ramírez ◽  
L. Mezzano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Cruzi Infection

scholarly journals Inducible Nitric Oxide Synthase Is Not Essential for Control of Trypanosoma cruzi Infection in Mice

2004 ◽  
Vol 72 (7) ◽  
pp. 4081-4089 ◽  
Author(s):  
Kara L. Cummings ◽  
Rick L. Tarleton
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Inducible Nitric Oxide Synthase ◽  
Interleukin 1 ◽  
Mouse Strains ◽  
Wild Type ◽  
Necrosis Factor Alpha ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

ABSTRACT Immune control of many intracellular pathogens, including Trypanosoma cruzi, is reported to be dependent on the production of nitric oxide. In this study, we show that mice deficient in inducible nitric oxide synthase (iNOS or NOS2) exhibit resistance to T. cruzi infection that is comparable to that of wild-type mice. This is the case for two iNOS-deficient mouse strains, Nos2tm1Lau and Nos2 N5, infected with the Brazil or Tulahuen strain of T. cruzi. In all cases, blood parasitemia, tissue parasite load, and survival rates are similar between wild-type and iNOS-deficient mice. In contrast, both wild-type and Nos2tm1Lau mice died within 32 days postinfection when treated with the nitric oxide synthase inhibitor aminoguanidine. Increased transcription of NOS1 or NOS3 is not found in iNOS-knockout (KO) mice, indicating that the absence of nitric oxide production through iNOS is not compensated for by increased production of other NOS isoforms. However, Nos2tm1Lau mice exhibit enhanced expression of tumor necrosis factor alpha, interleukin-1, and macrophage inflammatory protein 1α compared to that of wild-type mice, and these alterations may in part compensate for the lack of iNOS. These results clearly show that iNOS is not required for control of T. cruzi infection in mice.

Retinoic Acid Inhibits Nitric Oxide Synthase-2 Expression through the Retinoic Acid Receptor-α

2000 ◽  
Vol 270 (3) ◽  
pp. 846-851 ◽  
Author(s):  
Allan Sirsjö ◽  
Andreas C Gidlöf ◽  
Anneli Olsson ◽  
Hans Törmä ◽  
Mikko Ares ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Retinoic Acid ◽  
Nitric Oxide Synthase ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Deficiency of Nitric Oxide Synthase 2 Results in Increased Neointima Formation in a Mouse Model of Vascular Injury

2003 ◽  
Vol 41 (6) ◽  
pp. 897-902 ◽  
Author(s):  
Allan Sirsjö ◽  
Anders Löfving ◽  
Göran K. Hansson ◽  
Dick Wågsäter ◽  
Shinichi Tokuno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mouse Model ◽  
Vascular Injury ◽  
Neointima Formation ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

scholarly journals Nitric-oxide Synthase-2 Linkage to Focal Adhesion Kinase in Neutrophils Influences Enzyme Activity and β2Integrin Function

2013 ◽  
Vol 288 (7) ◽  
pp. 4810-4818 ◽  
Author(s):  
Stephen R. Thom ◽  
Veena M. Bhopale ◽  
Tatyana N. Milovanova ◽  
Ming Yang ◽  
Marina Bogush ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Enzyme Activity ◽  
Nitric Oxide Synthase ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase
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