Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase

1997 ◽  
Vol 6 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Huan Huang, MD ◽  
John Chan, MD ◽  
Murray Wittner, MD, PhD ◽  
Louis M Weiss, MD, MPH ◽  
J Bacchi, PhD ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Oxide Synthase ◽  
Cruzi Infection

Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice

2018 ◽  
Vol 129 ◽  
pp. 227-236 ◽  
Author(s):  
Amanda A. Felizardo ◽  
Ivo S. Caldas ◽  
Andréa A.S. Mendonça ◽  
Reggiani V. Gonçalves ◽  
Fernanda L. Tana ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Oxide Synthase ◽  
Cruzi Infection ◽  
Expression And Activity

Association of nitric oxide synthase 2(NOS2G-954C) polymorphism with cardiomyopathy in Trypanosoma cruzi infection

2005 ◽  
Vol 66 (8) ◽  
pp. 68
Author(s):  
Mercedes T. Fernandez-Mestre ◽  
Eva Salazar ◽  
Zulay E. Layrisse
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase ◽  
Cruzi Infection

Placental Trypanosoma cruzi infection is restricted by nitric oxide production by endothetial nitric oxide synthase isoform

Placenta ◽  
2017 ◽  
Vol 51 ◽  
pp. 116-117
Author(s):  
M.F. Triquell ◽  
E. Benizio ◽  
M.J. Moreira-Espinoza ◽  
J.C. Ramírez ◽  
L. Mezzano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Cruzi Infection

Chronic rapamycin pretreatment modulates arginase/inducible nitric oxide synthase balance attenuating aging-dependent susceptibility to Trypanosoma cruzi infection and acute myocarditis

2021 ◽  
pp. 111676
Author(s):  
Margarida Pereira-Santos ◽  
Elda Gonçalves-Santos ◽  
Matheus Augusto Souza ◽  
Ivo Santana Caldas ◽  
Graziela Domingues Almeida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Inducible Nitric Oxide Synthase ◽  
Acute Myocarditis ◽  
Oxide Synthase ◽  
Cruzi Infection ◽  
Inducible Nitric Oxide

scholarly journals Inducible Nitric Oxide Synthase Is Not Essential for Control of Trypanosoma cruzi Infection in Mice

2004 ◽  
Vol 72 (7) ◽  
pp. 4081-4089 ◽  
Author(s):  
Kara L. Cummings ◽  
Rick L. Tarleton
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Inducible Nitric Oxide Synthase ◽  
Interleukin 1 ◽  
Mouse Strains ◽  
Wild Type ◽  
Necrosis Factor Alpha ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

ABSTRACT Immune control of many intracellular pathogens, including Trypanosoma cruzi, is reported to be dependent on the production of nitric oxide. In this study, we show that mice deficient in inducible nitric oxide synthase (iNOS or NOS2) exhibit resistance to T. cruzi infection that is comparable to that of wild-type mice. This is the case for two iNOS-deficient mouse strains, Nos2tm1Lau and Nos2 N5, infected with the Brazil or Tulahuen strain of T. cruzi. In all cases, blood parasitemia, tissue parasite load, and survival rates are similar between wild-type and iNOS-deficient mice. In contrast, both wild-type and Nos2tm1Lau mice died within 32 days postinfection when treated with the nitric oxide synthase inhibitor aminoguanidine. Increased transcription of NOS1 or NOS3 is not found in iNOS-knockout (KO) mice, indicating that the absence of nitric oxide production through iNOS is not compensated for by increased production of other NOS isoforms. However, Nos2tm1Lau mice exhibit enhanced expression of tumor necrosis factor alpha, interleukin-1, and macrophage inflammatory protein 1α compared to that of wild-type mice, and these alterations may in part compensate for the lack of iNOS. These results clearly show that iNOS is not required for control of T. cruzi infection in mice.

scholarly journals Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Carolina Panis ◽  
Vanessa Jacob Victorino ◽  
Vera Lúcia Hideko Tatakihara ◽  
Rubens Cecchini ◽  
Luiz Vicente Rizzo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Response ◽  
Trypanosoma Cruzi ◽  
Early Stage ◽  
Inos Activity ◽  
Heart Injury ◽  
Oxide Synthase ◽  
Inos Inhibition ◽  
And Oxidative Stress ◽  
Cruzi Infection

Infection with the protozoan Trypanosoma cruzi causes Chagas disease and consequently leads to severe inflammatory heart condition; however, the mechanisms driving this inflammatory response have not been completely elucidated. Nitric oxide (NO) is a key mediator of parasite killing in T. cruzi-infected mice, and previous studies have suggested that leukotrienes (LTs) essentially regulate the NO activity in the heart. We used infected 5-lipoxygenase-deficient mice (5-LO−/−) to explore the participation of nitric oxide synthase isoforms, inducible (iNOS) and constitutive (cNOS), in heart injury, cytokine profile, and oxidative stress during the early stage of T. cruzi infection. Our evidence suggests that the cNOS of the host is involved in the resistance of 5-LO−/− mice during T. cruzi infection. iNOS inhibition generated a remarkable increase in T. cruzi infection in the blood and heart of mice, whereas cNOS inhibition reduced cardiac parasitism (amastigote nests). Furthermore, this inhibition associates with a higher IFN-γ production and lower lipid peroxidation status. These data provide a better understanding about the influence of NO-interfering therapies for the inflammatory response toward T. cruzi infection.

scholarly journals Neurodegeneration and Increased Production of Nitrotyrosine, Nitric Oxide Synthase, IFN-γ and S100β Protein in the Spinal Cord of IL-12p40-Deficient Mice Infected with Trypanosoma cruzi

2010 ◽  
Vol 17 (2) ◽  
pp. 67-78 ◽  
Author(s):  
André Luis Bombeiro ◽  
Maria Regina D’Império Lima ◽  
Gerson Chadi ◽  
José Maria Álvarez
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
S100β Protein ◽  
Ifn Γ ◽  
Oxide Synthase ◽  
Deficient Mice

scholarly journals Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytes

2008 ◽  
Vol 10 (14-15) ◽  
pp. 1558-1566 ◽  
Author(s):  
Fabiana S. Machado ◽  
Janeusa T. Souto ◽  
Marcos A. Rossi ◽  
Lisia Esper ◽  
Herbert B. Tanowitz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Trypanosoma Cruzi ◽  
Cardiac Myocytes ◽  
Chemokine Production ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document