Identification of novel human leukocyte antigen G alleles in an East African population by high-resolution sequence-based typing

2008 ◽  
Vol 69 (7) ◽  
pp. 426-429 ◽  
Author(s):  
William J.R. Turk ◽  
Xiao-Juan Mao ◽  
Thomas Bielawny ◽  
Robert Brunham ◽  
Ma Luo ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
African Population ◽  
East African ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G

scholarly journals High Resolution Human Leukocyte Antigen Class I Allele Frequencies and HIV-1 Infection Associations in Chinese Han and Uyghur Cohorts

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e50656
Author(s):  
Yanhou Liu ◽  
Zhongfang Zhao ◽  
Tianyi Li ◽  
Qi Liao ◽  
Nicholas Kushner ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Allele Frequencies ◽  
Class I ◽  
Chinese Han ◽  
Leukocyte Antigen ◽  
Hiv 1 ◽  
Leukocyte Antigen Class I

Expression of human leukocyte antigen-G in systemic lupus erythematosus

2008 ◽  
Vol 69 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Silvia Rosado ◽  
Gema Perez-Chacon ◽  
Susana Mellor-Pita ◽  
Inmaculada Sanchez-Vegazo ◽  
Carmen Bellas-Menendez ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Human Leukocyte Antigen ◽  
Lupus Erythematosus ◽  
Human Leukocyte ◽  
Systemic Lupus ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G

scholarly journals Human Herpesvirus 6A and 6B inhibit in vitro angiogenesis by induction of Human Leukocyte Antigen G

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Roberta Rizzo ◽  
Maria D’Accolti ◽  
Daria Bortolotti ◽  
Francesca Caccuri ◽  
Arnaldo Caruso ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Herpesvirus ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
In Vitro Angiogenesis

scholarly journals Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors

2021 ◽  
Vol 9 (10) ◽  
pp. e003050
Author(s):  
Chia-Ing Jan ◽  
Shi-Wei Huang ◽  
Peter Canoll ◽  
Jeffrey N Bruce ◽  
Yu-Chuan Lin ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Natural Killer ◽  
Solid Tumors ◽  
Low Dose ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Low Dose Chemotherapy ◽  
Human Leukocyte Antigen G

BackgroundImmunotherapy against solid tumors has long been hampered by the development of immunosuppressive tumor microenvironment, and the lack of a specific tumor-associated antigen that could be targeted in different kinds of solid tumors. Human leukocyte antigen G (HLA-G) is an immune checkpoint protein (ICP) that is neoexpressed in most tumor cells as a way to evade immune attack and has been recently demonstrated as a useful target for chimeric antigen receptor (CAR)-T therapy of leukemia by in vitro studies. Here, we design and test for targeting HLA-G in solid tumors using a CAR strategy.MethodsWe developed a novel CAR strategy using natural killer (NK) cell as effector cells, featuring enhanced cytolytic effect via DAP12-based intracellular signal amplification. A single-chain variable fragment (scFv) against HLA-G is designed as the targeting moiety, and the construct is tested both in vitro and in vivo on four different solid tumor models. We also evaluated the synergy of this anti-HLA-G CAR-NK strategy with low-dose chemotherapy as combination therapy.ResultsHLA-G CAR-transduced NK cells present effective cytolysis of breast, brain, pancreatic, and ovarian cancer cells in vitro, as well as reduced xenograft tumor growth with extended median survival in orthotopic mouse models. In tumor coculture assays, the anti-HLA-G scFv moiety promotes Syk/Zap70 activation of NK cells, suggesting reversal of the HLA-G-mediated immunosuppression and hence restoration of native NK cytolytic functions. Tumor expression of HLA-G can be further induced using low-dose chemotherapy, which when combined with anti-HLA-G CAR-NK results in extensive tumor ablation both in vitro and in vivo. This upregulation of tumor HLA-G involves inhibition of DNMT1 and demethylation of transporter associated with antigen processing 1 promoter.ConclusionsOur novel CAR-NK strategy exploits the dual nature of HLA-G as both a tumor-associated neoantigen and an ICP to counteract tumor spread. Further ablation of tumors can be boosted when combined with administration of chemotherapeutic agents in clinical use. The readiness of this novel strategy envisions a wide applicability in treating solid tumors.

scholarly journals EVALUATION OF A NOVEL ULTRA-HIGH-RESOLUTION ASSAY AND ANALYTIC SOFTWARE FOR NEXT GENERATION SEQUENCING BASED GENOTYPING OF 11 HUMAN LEUKOCYTE ANTIGEN LOCI

2020 ◽  
Vol 104 (S3) ◽  
pp. S310-S310
Author(s):  
Ji Yeon Kim ◽  
Hae-In Song ◽  
Mi Mi Jang ◽  
Kyoungyong Jung ◽  
Soo Ho Park ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
High Resolution ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Next Generation ◽  
Leukocyte Antigen ◽  
Generation Sequencing

Post-transplant increase in soluble human leukocyte antigen-G associated with non-severe cardiac allograft vasculopathy

2013 ◽  
Vol 74 (3) ◽  
pp. 318-324 ◽  
Author(s):  
R.M. Blanco-García ◽  
M.R. López-Álvarez ◽  
I.P. Garrido ◽  
G. Salgado-Cecilia ◽  
J.A. Campillo ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Allograft Vasculopathy ◽  
Leukocyte Antigen ◽  
Post Transplant ◽  
Human Leukocyte Antigen G

Correlation of Human Leukocyte Antigen-G (HLA-G) Expression and Disease Progression in Epithelial Ovarian Cancer

2009 ◽  
Vol 16 (11) ◽  
pp. 1103-1111 ◽  
Author(s):  
Yong Wook Jung ◽  
Young Tae Kim ◽  
Sang Wun Kim ◽  
Sunghoon Kim ◽  
Jae Hoon Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Human Leukocyte Antigen ◽  
Epithelial Ovarian Cancer ◽  
Disease Progression ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G
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