GATA3 expression in small cell carcinoma of bladder and prostate and its potential role in determining primary tumor origin

2014 ◽  
Vol 45 (8) ◽  
pp. 1682-1687 ◽  
Author(s):  
Stephania Martins Bezerra ◽  
Tamara Levin Lotan ◽  
Sheila Friedrich Faraj ◽  
Sarah Karram ◽  
Rajni Sharma ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumor ◽  
Potential Role ◽  
Small Cell ◽  
Tumor Origin ◽  
Gata3 Expression

scholarly journals Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Debebe Theodros ◽  
C. Rory Goodwin ◽  
Genevieve M. Crane ◽  
Jason Liauw ◽  
Lawrence Kleinberg ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Surgical Resection ◽  
Small Cell Carcinoma ◽  
Vestibular Schwannoma ◽  
Primary Tumor ◽  
Cerebellopontine Angle ◽  
Internal Auditory Canal ◽  
Small Cell ◽  
Poorly Differentiated ◽  
Small Intestinal

Extrapulmonary small cell carcinomas (EPSCC) are rare malignancies with poor patient prognoses. We present the case of a 63-year-old male who underwent surgical resection of a poorly differentiated small cell carcinoma, likely from a small intestinal primary tumor that metastasized to the cerebellopontine angle (CPA). A 63-year-old male presented with mild left facial paralysis, hearing loss, and balance instability. MRI revealed a 15 mm mass in the left CPA involving the internal auditory canal consistent with a vestibular schwannoma. Preoperative MRI eight weeks later demonstrated marked enlargement to 35 mm. The patient underwent a suboccipital craniectomy and the mass was grossly different visually and in consistency from a standard vestibular schwannoma. The final pathology revealed a poorly differentiated small cell carcinoma. Postoperative PET scan identified avid uptake in the small intestine suggestive of either a small intestinal primary tumor or additional metastatic disease. The patient underwent whole brain radiation therapy and chemotherapy and at last follow-up demonstrated improvement in his symptoms. Surgical resection and radiotherapy are potential treatment options to improve survival in patients diagnosed with NET brain metastases. We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.

Small Cell Carcinoma: An Unusual Primary Tumor of Esophagus

2011 ◽  
Vol 106 ◽  
pp. S177
Author(s):  
Liliane Deeb ◽  
Kenneth Banner ◽  
Jinjuan Yao ◽  
Gurinder Sidhu ◽  
Safak Reka
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumor ◽  
Small Cell

Extrapulmonary Small Cell Carcinoma: Multimodality Treatment Results

2003 ◽  
Vol 89 (3) ◽  
pp. 274-277 ◽  
Author(s):  
Meric Sengoz ◽  
Ufuk Abacioglu ◽  
Taflan Salepci ◽  
Funda Eren ◽  
Fulden Yumuk ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Median Survival ◽  
Primary Tumor ◽  
Multimodality Treatment ◽  
Small Cell ◽  
Treatment Results ◽  
Extensive Disease ◽  
Primary Tumor Site ◽  
Extrapulmonary Small Cell Carcinoma

Aims and Background Extrapulmonary small cell carcinoma is a distinct entity that can occur in many sites, and it is pathologically similar to small-cell lung cancer. We report the results of a retrospective study of a multimodality treatment of 16 consecutive patients with a diagnosis of extrapulmonary small-cell carcinoma. Methods Primary tumor site was prostate in 2, gallbladder in 2, uterine cervix in 2, liver in 2, endometrium in 1, epididymis in 1, colon in 1, larynx in 1, breast in 1, and unknown primary tumor in 3 patients. Patients’ ages ranged from 19 to 79 years (median, 62). Nine patients had limited and 7 had extensive disease. Histologically, 14 were pure extrapulmonary small-cell carcinoma and 2 were mixed with squamous-cell carcinoma. Results Curative surgery was attempted in 8 patients. Seven patients received local-regional adjuvant radiotherapy. All patients, except the one with a breast primary, were treated with chemotherapy (mostly platinum-based regimens). Overall survival for all patients was 41% and 11% at 2 and 5 years, respectively (median survival, 14 months). Median survival for patients with limited disease was 25 months compared to 12 months for patients with extensive disease (P = 0.05). Conclusions Treatment results for extrapulmonary small-cell carcinoma are comparable to those of small-cell carcinomas of the lung. Extent of disease is a significant prognostic factor for survival.

The role of surgery in the management of selected patients with small-cell carcinoma of the lung.

1987 ◽  
Vol 5 (5) ◽  
pp. 697-702 ◽  
Author(s):  
R R Baker ◽  
D S Ettinger ◽  
J D Ruckdeschel ◽  
J C Eggleston ◽  
M F McKneally ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumor ◽  
Residual Disease ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Operative Specimen

This study was designed to evaluate the efficacy of surgical resection of the primary tumor and lymph nodes in patients with localized small-cell carcinoma who had responded to induction chemotherapy. The study was performed in 37 patients who received two cycles of chemotherapy consisting of cyclophosphamide, doxorubicin, and etoposide. Those patients who achieved a complete or partial (greater than 50%) response were evaluated for thoracotomy and the primary tumor and regional lymph nodes excised when feasible. Postoperatively, the patients received prophylactic cranial irradiation and were maintained on the same chemotherapy for an average of 11 months. Twelve patients were resected and found to have residual small-cell carcinoma in the operative specimen (ten) or no residual disease (two). Seven of these patients (58%) are alive without evidence of disease (median follow-up, 24 months). Seven other patients who were resected proved to have either residual foci or small-cell carcinoma mixed with adenocarcinoma or large-cell carcinoma (four) or only focal areas of adenocarcinoma, large-cell carcinoma, or squamous-cell carcinoma with no evidence of residual small-cell carcinoma. Five of these patients (71%) are alive without evidence of disease (median follow-up, 36 months). Two of the 16 patients who were not resected but treated with chemotherapy and radiation are alive at 15 and 31 months without evidence of disease, the other 14 are dead of disease.

scholarly journals EPID-04. THE SINGLE CENTER STUDY FOR BRAIN METASTASES OF UNDIAGNOSED PRIMARY TUMOR AND THE ROLE OF SURGICAL REMOVAL

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii79-ii79
Author(s):  
Yuzaburo Shimizu ◽  
Mario Suzuki ◽  
Osamu Akiyama ◽  
Akihide Kondo
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumor ◽  
Surgical Intervention ◽  
Small Cell ◽  
Surgical Removal ◽  
Primary Tumors

Abstract BACKGROUND The diagnosis of a brain metastases is generally made during the follow up examinations of patients with primary known cancer. However, there are some patients presenting brain metastases as the first manifestation of a previously undiagnosed primary tumor (UDP) pathological confirmation of the diagnosis. The timing of a subsequent neurosurgical intervention is influenced by the distribution of primary tumors in UDP patients. The purpose of this study was to investigate the optimal diagnostic approach and the role of surgery for UDP patients. METHODS In a retrospective study, 35 patients admitted to our institution and underwent brain tumor removal from 2017 to 2019 with the diagnosis of cerebral metastases and diagnosed lung cancer as primary tumor subsequently, or previously diagnosed lung cancer. RESULTS UDP patients represented 46% of the whole group. Primary tumor subtype was the adenocarcinoma (n=13, 81%), small cell carcinoma (n=2, 13%), and neuroendocrine carcinoma (n=1, 6%). They did not have bronchoscopy nor excision of lung cancer. On the other hand, the patients previously diagnosed lung cancer represented 54% and subtype was adenocarcinoma (n=14, 74%) and small cell carcinoma (n=5, 26%). EGFR mutation was detected from 7 patients (44%) in UDP group and treated by EGFR tyrosine kinase inhibitor. CONCLUSION The significance of surgical intervention in metastatic brain tumors has been limited. However, active surgical intervention in UDP patients could identify not only histological diagnosis but also molecular biological characteristics. Our study suggests the possibility to avoid whole brain radiation in UDP patient by the active surgery.

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