Extrapulmonary Small Cell Carcinoma: Multimodality Treatment Results

2003 ◽  
Vol 89 (3) ◽  
pp. 274-277 ◽  
Author(s):  
Meric Sengoz ◽  
Ufuk Abacioglu ◽  
Taflan Salepci ◽  
Funda Eren ◽  
Fulden Yumuk ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Median Survival ◽  
Primary Tumor ◽  
Multimodality Treatment ◽  
Small Cell ◽  
Treatment Results ◽  
Extensive Disease ◽  
Primary Tumor Site ◽  
Extrapulmonary Small Cell Carcinoma

Aims and Background Extrapulmonary small cell carcinoma is a distinct entity that can occur in many sites, and it is pathologically similar to small-cell lung cancer. We report the results of a retrospective study of a multimodality treatment of 16 consecutive patients with a diagnosis of extrapulmonary small-cell carcinoma. Methods Primary tumor site was prostate in 2, gallbladder in 2, uterine cervix in 2, liver in 2, endometrium in 1, epididymis in 1, colon in 1, larynx in 1, breast in 1, and unknown primary tumor in 3 patients. Patients’ ages ranged from 19 to 79 years (median, 62). Nine patients had limited and 7 had extensive disease. Histologically, 14 were pure extrapulmonary small-cell carcinoma and 2 were mixed with squamous-cell carcinoma. Results Curative surgery was attempted in 8 patients. Seven patients received local-regional adjuvant radiotherapy. All patients, except the one with a breast primary, were treated with chemotherapy (mostly platinum-based regimens). Overall survival for all patients was 41% and 11% at 2 and 5 years, respectively (median survival, 14 months). Median survival for patients with limited disease was 25 months compared to 12 months for patients with extensive disease (P = 0.05). Conclusions Treatment results for extrapulmonary small-cell carcinoma are comparable to those of small-cell carcinomas of the lung. Extent of disease is a significant prognostic factor for survival.

scholarly journals Small Cell Carcinoma of the Renal Pelvis: A Case Report and Review of the Literature

ISRN Urology ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Sachin Patil ◽  
R. C. M. Kaza ◽  
A. K. Kakkar ◽  
Ronald S. Chamberlain
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Median Survival ◽  
Renal Pelvis ◽  
Small Cell ◽  
Common Symptom ◽  
Current Case ◽  
Duration Of Symptoms ◽  
The Central Nervous System ◽  
Extrapulmonary Small Cell Carcinoma

Extrapulmonary small cell carcinoma occurs in nearly all organs except the central nervous system and the liver. We are presenting a case of renal small cell carcinoma (SCC) with two unique characters. A 75-year-old patient was evaluated for back pain with no other complaints. Magnetic Resonance (MR) imaging of the abdomen revealed homogeneous tumor in the left renal pelvis extending beyond the kidney. Metastatic workup was negative. A left nephroureterectomy was performed. Histopathology and immunohistochemistry revealed a small cell carcinoma of the renal pelvis. The patient declined adjuvant therapy and died 2 months after surgery due to unrelated causes. After comprehensive worldwide literature search, we found 13 cases of SCC of the renal pelvis, including the current case. The mean age was 61.6 years (37–83), with a M : F ratio of 1 : 1.8. The average duration of symptoms was 71.4 days (21–168). Gross hematuria was the most common symptom (69.2%) followed by pain (61.5%). Adjuvant chemotherapy was provided to 4 patients (30.7%), and neoadjuvant to 1 patient. The median survival of patients who did and did not receive chemotherapy was 5.5 months (3–8) and 6 months (2–31), respectively, P<.50. In conclusion, renal SCC (both parenchymal and pelvic SCC) is a rapidly fatal disease with a median survival of ≤8 months.

scholarly journals Effective Monotherapy with Amrubicin for a Refractory Extrapulmonary Small-Cell Carcinoma of the Liver

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Taichi Isobe ◽  
Shunichi Yanai ◽  
Hitoshi Kusaba ◽  
Shinichiro Yada ◽  
Yosuke Kuroda ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Disease Stage ◽  
Extensive Disease ◽  
First Case ◽  
Extrapulmonary Small Cell Carcinoma ◽  
Third Line ◽  
The Masses ◽  
Line Chemotherapy

Small-cell carcinoma of the liver is a rare neoplasm, and no standard treatment for it has yet been established. A 72-year-old man with an extensive disease stage of small-cell carcinoma of the liver was treated with systemic chemotherapy consisting of cisplatin and etoposide (PE) followed by irinotecan. Although the masses were markedly decreased once after the sixth course of PE, amrubicin monotherapy as third-line chemotherapy was started because the hepatic masses had increased again. The administration of amrubicin was repeated in 8 courses with regression of the disease, resulting in a 26-month survival since the first-line chemotherapy was started. This is the first case report of a refractory EPSCC successfully treated with amrubicin.

scholarly journals Patterns of relapse in extrapulmonary small cell carcinoma: retrospective analysis of outcomes from two cancer centres

BMJ Open ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. e006440-e006440 ◽  
Author(s):  
S. Gennatas ◽  
J. Noble ◽  
S. Stanway ◽  
R. Gunapala ◽  
R. Chowdhury ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Retrospective Analysis ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Extrapulmonary Small Cell Carcinoma

Primary Extrapulmonary Small Cell Carcinoma of the Appendix - A Case Report -

2010 ◽  
Vol 44 (1) ◽  
pp. 101
Author(s):  
Jong Hyeok Park ◽  
Ki Jae Park ◽  
Young Hoon Roh ◽  
Mee Sook Roh
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Extrapulmonary Small Cell Carcinoma

scholarly journals Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Debebe Theodros ◽  
C. Rory Goodwin ◽  
Genevieve M. Crane ◽  
Jason Liauw ◽  
Lawrence Kleinberg ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Surgical Resection ◽  
Small Cell Carcinoma ◽  
Vestibular Schwannoma ◽  
Primary Tumor ◽  
Cerebellopontine Angle ◽  
Internal Auditory Canal ◽  
Small Cell ◽  
Poorly Differentiated ◽  
Small Intestinal

Extrapulmonary small cell carcinomas (EPSCC) are rare malignancies with poor patient prognoses. We present the case of a 63-year-old male who underwent surgical resection of a poorly differentiated small cell carcinoma, likely from a small intestinal primary tumor that metastasized to the cerebellopontine angle (CPA). A 63-year-old male presented with mild left facial paralysis, hearing loss, and balance instability. MRI revealed a 15 mm mass in the left CPA involving the internal auditory canal consistent with a vestibular schwannoma. Preoperative MRI eight weeks later demonstrated marked enlargement to 35 mm. The patient underwent a suboccipital craniectomy and the mass was grossly different visually and in consistency from a standard vestibular schwannoma. The final pathology revealed a poorly differentiated small cell carcinoma. Postoperative PET scan identified avid uptake in the small intestine suggestive of either a small intestinal primary tumor or additional metastatic disease. The patient underwent whole brain radiation therapy and chemotherapy and at last follow-up demonstrated improvement in his symptoms. Surgical resection and radiotherapy are potential treatment options to improve survival in patients diagnosed with NET brain metastases. We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.

scholarly journals Extrapulmonary small cell carcinoma: A single-institution experience and review of the literature

1994 ◽  
Vol 5 (10) ◽  
pp. 909-913 ◽  
Author(s):  
G. Lo Re ◽  
V. Canzonieri ◽  
A. Veronesi ◽  
V.Dal Bo ◽  
L. Barzan ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Review Of The Literature ◽  
Single Institution ◽  
Extrapulmonary Small Cell Carcinoma

Extrapulmonary small cell carcinoma: Prognostic factors, patterns of care, and overall survival

2020 ◽  
Vol 46 (9) ◽  
pp. 1596-1604 ◽  
Author(s):  
Steven F. Mandish ◽  
Jeremy T. Gaskins ◽  
Mehran B. Yusuf ◽  
Brendan P. Little ◽  
Neal E. Dunlap
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Patterns Of Care ◽  
Extrapulmonary Small Cell Carcinoma

Effect of initial resection of small-cell carcinoma of the lung: a review of Southwest Oncology Group Study 7628.

1985 ◽  
Vol 3 (7) ◽  
pp. 964-968 ◽  
Author(s):  
G G Friess ◽  
J D McCracken ◽  
M L Troxell ◽  
R Pazdur ◽  
C A Coltman ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Survival Time ◽  
Surgical Resection ◽  
Small Cell Carcinoma ◽  
Median Survival ◽  
Median Survival Time ◽  
Small Cell ◽  
Oncology Group ◽  
Primary Tumors ◽  
Southwest Oncology Group

The role of surgery in small-cell carcinoma of the lung (SCCL) has been recently re-evaluated. We reviewed the records of 262 patients with limited SCCL on Southwest Oncology Group (SWOG) protocol 7628. Fifteen patients were identified who presented after surgical resection (12 lobectomy, three pneumonectomy). All patients were subsequently treated with chemotherapy, radiotherapy +/- immunotherapy (BCG). Median survival time was 10.5 months. Median survival time of patients with initial surgical resection was 25 months (P = .004). Forty-five percent of the surgical patients were alive at two years v 13.7% of the nonsurgical patients (P less than .05). A second subgroup of 33 patients was identified with small primary tumors who did not undergo surgical resection. Median survival time in this group was ten months (P = .03). Site of initial relapse was clearly documented in 142 patients. Fifty-six percent of patients not receiving surgery had initial relapse within the chest compared to 13% of patients undergoing surgery (P = .002). Whether the survival benefit identified was caused by or was incidental to surgical resection of the primary lesion remains to be determined in randomized prospective trials of operable candidates.

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