scholarly journals Coronary artery disease in premenopausal versus postmenopausal women - Risk factors, clinical profile and angiographic characteristics

2021 ◽  
Vol 73 ◽  
pp. S2
Author(s):  
P. Praveen Kumar ◽  
T. Munusamy ◽  
J. Nambirajan
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Clinical Profile ◽  
Artery Disease

Study on Clinical Profile and risk factors of Coronary Artery Disease in Indian Women

2018 ◽  
Vol 4 (2) ◽  
pp. 94-99
Author(s):  
Keshavamurthy Ganapathy Bhat ◽  
◽  
Krishnakumar Kanniyyappan ◽  
Bhupinder Kaur Anand ◽  
Marwaha Manvinder Pal Singh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Clinical Profile ◽  
Indian Women ◽  
Artery Disease

scholarly journals Diabetes mellitus and other cardiovascular risk factors in lower-extremity peripheral artery disease versus coronary artery disease: an analysis of 1,121,359 cases from the nationwide databases

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Mitsuyoshi Takahara ◽  
◽  
Osamu Iida ◽  
Shun Kohsaka ◽  
Yoshimitsu Soga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Lower Extremity ◽  
Cardiovascular Risk Factors ◽  
Clinical Profile ◽  
Peripheral Artery ◽  
Artery Disease

Abstract Background Lower-extremity peripheral artery disease (LE-PAD) and coronary artery disease (CAD) are both pathologically rooted in atherosclerosis, and their shared clinical features regarding the exposure to cardiovascular risk factors have been emphasized. However, comparative data of the two cardiovascular diseases (CVDs) were so far lacking. The purpose of this study was to directly compare the clinical profile between cases undergoing endovascular therapy (EVT) for LE-PAD and those undergoing percutaneous coronary intervention (PCI). Methods Data were extracted from the nationwide procedural databases of EVT and PCI in Japan (J-EVT and J-PCI) between 2012 and 2017. A total of 1,121,359 cases (103,887 EVT cases for critical limb ischemia [CLI] or intermittent claudication and 1,017,472 PCI cases for acute coronary syndrome [ACS] or stable angina) were analyzed. Heterogeneity in clinical profile between CVDs was evaluated using the C statistic of the logistic regression model for which dependent variable was one CVD versus another, and explanatory variables were clinical profile. When two CVDs were completely discriminated from each other by the developed model, the C statistic (discrimination ability) of the model would be equal to 1, indicating that the two CVDs were completely different in clinical profile. On the other hand, when two CVDs were identical in clinical profile, the developed model would not discriminate them at all, with the C statistic equal to 0.5. Results Mean age was 73.5 ± 9.3 years in LE-PAD patients versus 70.0 ± 11.2 years in CAD patients (P < 0.001). The prevalence of diabetes mellitus and end-stage renal disease was 1.96- and 6.39-times higher in LE-PAD patients than in CAD patients (both P < 0.001). The higher prevalence was observed irrespective of age group. The exposure to other cardiovascular risk factors and the likelihood of cardiovascular risk clustering also varied between the diseases. The between-disease heterogeneity in patient profile was particularly evident between CLI and ACS, with the C statistic equal to 0.833 (95% CI 0.831–0.836). Conclusions The current study, an analysis based on nationwide procedural databases, confirmed that patient profiles were not identical but rather considerably different between clinically significant LE-PAD and CAD warranting revascularization.

scholarly journals Association between Endogenous Sex Hormones and Coronary Artery Disease in Postmenopausal Women

2021 ◽  
Author(s):  
Roopali Khanna ◽  
Avinash Bansal ◽  
Sudeep Kumar ◽  
Naveen Garg ◽  
Satyendra Tewari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Vessel Disease ◽  
Triple Vessel Disease ◽  
Traditional Risk Factors ◽  
Artery Disease

Background Incidence of coronary artery disease (CAD) increases significantly in postmenopausal women, which is assumed to be an imbalance between serum androgen and estrogen levels. However, studies assessing serum sex hormones and CAD are few and have shown conflicting results. Objective To compare serum sex hormone levels and traditional risk factors among postmenopausal women with angiographically proven CAD and without CAD. Method The study included consecutive postmenopausal women undergoing coronary angiography in our institute from May 2016 to June 2017. The clinical and coronary angiographic data and traditional risk factors were assessed. Fasting serum levels of estradiol (E2), testosterone (T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S), and insulin were measured. Results A total of 121 postmenopausal women were included in the study; 69 were CAD and 52 without CAD. Single-vessel disease was most common (55.1%), followed by double-vessel disease (24.6%) and triple-vessel disease (20.3%). Women with CAD had significantly lower estradiol/testosterone (E2/T) ratio (3.7 ± 2.6 vs. 5.4 ± 4.2, p = 0.008) compared with non-CAD group. SHBG, DHEA-S, and insulin levels were similar in CAD and non-CAD groups. The serum level of estradiol predicted the E2/T ratio (r = 0.316, p < 0.001) and positively associated with DHEA (r = 0.181, p = 0.047). Testosterone was negatively associated with E2/T ratio (r = – 0.682, p < 0.001). There was no significant correlation of estrogen, testosterone, or E2/T ratio to lipid profile (total cholesterol, HDL, LDL) in women with CAD. Conclusion E2/T ratio was significantly lowered in postmenopausal women with CAD. E2/T ratio may be a used a predictor of CAD in postmenopausal women

scholarly journals Risk Factors Analysis and Angiographic Profile in Postmenopausal Women with Coronary Artery Disease

1970 ◽  
Vol 1 (2) ◽  
pp. 161-164
Author(s):  
AAS Majumder ◽  
S Nasrin ◽  
AQM Reza ◽  
MAU Chowdhury
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Independent Predictor ◽  
Study Group ◽  
Estrogen Level ◽  
Group I ◽  
Group Ii ◽  
Artery Disease

Background : Postmenopausal women are at greater risk for coronary artery disease (CAD) than premenopausal women. This may be due to deprivation of estrogen, which acts directly and indirectly on the vasculature. In light of this finding the aim of the study was to find the relation of serum estrogen level with severity of atherosclerotic lesion and number of risk factors in CAD among postmenopausal women. Methods: One hundred postmenopausal women undergoing coronary angiography (CAG) were studied. Among them 50 patients with estrogen level <25 pg/ml constituted study Group I and another 50 postmenopausal women with >25 pg/ml constituted study Group II. Serum estrogen level was measured by radioimmunoassay. Other important risk factors like dyslipidaemia, diabetes mellitus, hypertension, family history of CAD, smoking and waist circumference were evaluated between the 2 groups of patients. CAG findings were analyzed by eye estimation and by Gensini score. Results: All the risk factors were significantly higher in Group I patients than that of Group II. Among the risk factors hypertension was most prevalent (64%) in Group I and dyslipidaemia (40%) in Group II. Multivariate regression analysis showed that serum estrogen was a strong and an independent predictor of CAD (p=0.001) when considered with other standard risk factors. Association between the angiographic severity of CAD and serum estrogen level were evaluated and negative correlation was observed, i.e. lower the serum estrogen level higher the vessel score. Conclusion: In postmenopausal women serum estrogen level is a strong & an independent predictor of CAD. It is also found that low estrogen group of postmenopausal women with CAD have more severe atherosclerotic lesions in comparison to the group with normal estrogen level. Keywords: Risk factor, Coronary artery disease, Postmenopausal women, Angiographic profile. DOI: http://dx.doi.org/10.3329/cardio.v1i2.8235 Cardiovasc. j. 2009; 1(2): 161-164

scholarly journals Clinical Profile of Acute Coronary Syndrome

2021 ◽  
pp. 259-262
Author(s):  
Azeem Ahamed ◽  
N. Deepthi
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Tobacco Use ◽  
Metabolic Disorders ◽  
Clinical History ◽  
Clinical Profile ◽  
Coronary Syndrome ◽  
Artery Disease

Background: In the developing world, coronary artery disease (CAD) is considered to be a leading source of illness and ultimately death. Indians are nowadays linked to a more dangerous variant of coronary artery disease (CAD) with a lower age of onset and is more common in men. Aim: To analyse the clinical profile of patients with ACS syndrome for the purpose of drawing predominance in demography, metabolic disorders and tobacco use. Materials and Methods: We enrolled 50 patients with characteristic ECG alterations and clinical history who were admitted to the emergency department between January and August 2021 in a prospective research at Saveetha Medical College and Hospital. Every patient had a predetermined Performa filled out, which included a full clinical history and investigation procedures. The clinical history disclosed details regarding the patient's age, gender, and risk factors. Results: On analysis, results were conclusive of male predominance probably accentuated by tobacco use, alcohol consumption and other metabolic disorders. Conclusion: With prevalence of risk factors on rise, younger individuals are also affected. Proper risk factor management will help in preventing Acute coronary syndrome.

scholarly journals STUDY OF CORONARY ARTERY DISEASE IN WOMEN– THE INCIDENCE OF RISK FACTORS AND CLINICAL PROFILE

2017 ◽  
Vol 6 (53) ◽  
pp. 4042-4047
Author(s):  
Thiagarajan Chakravarthi ◽  
Sappani Kasipandian ◽  
Pasupulati Venkatasamy Krishnan
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Clinical Profile ◽  
Artery Disease

scholarly journals CLINICAL PROFILE OF PATIENTS WITH CORONARY TORTUOSITY AND ITS RELATION WITH CORONARY ARTERY DISEASE

2018 ◽  
Author(s):  
Ankush Gupta ◽  
Prashant Panda ◽  
YASH SHARMA ◽  
Ashwin Mahesh ◽  
Prafull Sharma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Chronic Stable Angina ◽  
Clinical Profile ◽  
Objective Evidence ◽  
Artery Disease ◽  
Coronary Tortuosity ◽  
Cad Risk

Background: Coronary tortuosity is a common angiographic finding. Scarce data is available on clinical profile of patients with coronary tortuosity (CT) and its relation with coronary artery disease (CAD). Method: A total 224 patients undergoing angiography for suspected CAD were included in the study. CT was defined by the presence of ≥3 consecutive bends of &gt; 45 degree measured at end-diastole in an epicardial artery ≥2 mm in diameter. CT was present in 45(20.08%) patients in the study and another 45 patients without CT was randomly selected as control (NCT group). Clinical profile of CT and NCT group was compared. Results: Incidence of CT was significantly higher in females (p=0.000) and hypertensives (p=0.001) patients. CT was most commonly seen in Left circumflex coronary artery. Incidence of CAD was significantly lower in CT group as compare to NCT group (0.02). Risk factors for CAD was associated with reduced incidence of CT. Majority (88.46%) patient with CT without CAD presented with chronic stable angina out of which (65.21%) had an objective evidence of myocardial ischemia. Conclusion: CT is more commonly seen females and hypertensive patients. It has negative correlation with CAD. Risk factors of CAD do not predict CT. CT itself can lead to myocardial ischemia.

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