High prevalence of plasmid-mediated quinolone resistance determinant aac(6′)-Ib-cr amongst Salmonella enterica serotype Typhimurium isolates from hospitalised paediatric patients with diarrhoea in China

2011 ◽  
Vol 37 (2) ◽  
pp. 152-155 ◽  
Author(s):  
Fangyou Yu ◽  
Qiang Chen ◽  
Xiaojun Yu ◽  
Jingye Pan ◽  
Qiaoqiao Li ◽  
...  
2009 ◽  
Vol 53 (7) ◽  
pp. 3112-3114 ◽  
Author(s):  
Marina Cerquetti ◽  
Aurora García-Fernández ◽  
Maria Giufrè ◽  
Daniela Fortini ◽  
Marisa Accogli ◽  
...  

ABSTRACT A qnrS1-positive strain of Escherichia coli was detected among 73 poultry isolates showing ciprofloxacin MICs of ≥0.125 μg/ml. The qnrS1 gene was associated with a Tn3-like transposon, as previously described to occur in a Salmonella enterica serovar Infantis strain of animal origin, but the plasmid scaffold carrying this element resembled that of a plasmid previously identified in Salmonella enterica serovar Dublin. These elements suggest genetic exchanges among Salmonella and E. coli and a potential animal reservoir for the qnr genes.


2017 ◽  
Vol 11 (1) ◽  
pp. 189-194 ◽  
Author(s):  
Shirin Malehmir ◽  
Reza Ranjbar ◽  
Naser Harzandi

Introduction:Salmonellais known as one of the most important causes of gastrointestinal disease in the world. Quinolones and fluoroquinolones are used successfully in the treatment of salmonellosis particularly for infections that have become resistant to several antibiotics. But non-susceptible isolates to quinolones have been reported in several countries. The data are limited about the prevalence of quinolone-resistant isolates in our country. Therefore, this study investigated the plasmid-mediated quinolone resistance genes inSalmonella entericaisolated in Children's Medical Center in Tehran during 2014-2015.Methods and Materials:Salmonellaisolates were isolated and identified using standard microbiological methods. Antibiotic susceptibility testing and screening ofSalmonellastrains resistant to quinolones were performed according to the CLSI guidelines. The molecular investigation was done using specific primers for detection of qnr genes including:qnrA,qnrB andqnrS, by polymerase chain reaction.Results:Overall, 92 (66.6%) strains were resistant to nalidixic acid. None of the strains showed resistance to ciprofloxacin. Out of the 92 nalidixic acid resistant strains, 52 (56.52%) harboredqnrS genes, 15 strains (16.30%) had bothqnrA andqnrS genes. Two (1.1%) isolates were positive forqnrB gene. Twenty four (26.08%) nalidixic acid resistant isolates did not have any qnr qens.Conclusion:The results of this study show high prevalence of resistance to nalidixic and qnr genes inSalmonellaisolates. Plasmid nature of this type of resistance poses an increased risk of dissemination of quinolone resistance betweenSalmonellaand non-Salmonellaisolates circulating in hospitals environments.


2012 ◽  
Vol 6 (05) ◽  
pp. 462-464 ◽  
Author(s):  
Fanny González ◽  
Lucia Pallecchi ◽  
Gian María Rossolini ◽  
María Araque

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2007 ◽  
Vol 59 (6) ◽  
pp. 1071-1075 ◽  
Author(s):  
Katie L. Hopkins ◽  
Lara Wootton ◽  
Martin R. Day ◽  
E. John Threlfall

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Przemyslaw Kardas ◽  
Marek Dabrowa ◽  
Konrad Witkowski

Abstract Background Due to high prevalence, non-adherence to prescribed treatment seriously undermines the effectiveness of evidence-based therapies in paediatric patients. In order to change this negative scenario, physicians need to be aware of adherence problem, as well as of possible solutions. Unfortunately, full potential of adherence-targeting interventions is still underused in Poland. Therefore, the aim of this study was to assess the knowledge, attitudes and behaviours toward non-adherence in Polish paediatricians. Methods An anonymous cross-sectional nationwide survey was conducted in the convenience sample of Polish doctors providing care to paediatric patients. The survey focused on the prevalence of non-adherence, its causes, and interventions employed. Primary studied parameter was perceived prevalence of non-adherence in paediatric patients. Reporting of this study adheres to STROBE guidelines. Results One thousand and thirty-three responses were eligible for analysis. Vast majority of respondents were female (85.9%), most of them worked in primary care (90.6%). The respondents represented all 16 Polish Voivodeships, with the biggest number coming from the Mazowieckie Voivodeship (n = 144, 13.9%). Survey participants believed that on average 28.9% of paediatric patients were non-adherent to medication. More than half of the respondents (n = 548, 53.0%) were convinced that their own patients were more adherent than average. Duration of the professional practice strongly correlated with a lower perceived prevalence of non-adherence. Professionals with more than 40 years of practice believed that the percentage of non-adherent patients was <=20% particularly often (OR = 3.82 (95% CI 2.11–6.93) versus those up to 10 years in practice). Out of all respondents, they were also most often convinced that their own patients were more adherent than the general population (P < 0.01). Consequently, they underestimated the need for training in this area. Conclusions Physicians taking care of Polish paediatric patients underestimated the prevalence of medication non-adherence and believed that this was a problem of other doctors. This optimistic bias was particularly pronounced in older doctors. These results identify important barriers toward improving patient adherence that are worth addressing in the pre- and post-graduate education of Polish physicians. They also put some light over the challenges that educational activities in this area may face.


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