Molecular level insight into the effect of triethyloctylammonium bromide on the structure, thermal stability, and activity of Bovine serum albumin

2018 ◽  
Vol 107 ◽  
pp. 186-193 ◽  
Author(s):  
Lakkoji Satish ◽  
Sabera Millan ◽  
Visakh Vijayalekshmi Sasidharan ◽  
Harekrushna Sahoo
Keyword(s):  
Thermal Stability ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Molecular Level ◽  
Insight Into

Thermal Aggregation of Bovine Serum Albumin in Conventional Buffers: An Insight into Molecular Level Interactions

2017 ◽  
Vol 46 (4) ◽  
pp. 831-848 ◽  
Author(s):  
Lakkoji Satish ◽  
Sabera Millan ◽  
Satyabrata Das ◽  
Sarita Jena ◽  
Harekrushna Sahoo
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Molecular Level ◽  
Thermal Aggregation ◽  
Insight Into

New insight into the stereoselective interactions of quinine and quinidine, with bovine serum albumin

2014 ◽  
Vol 27 (5) ◽  
pp. 239-249 ◽  
Author(s):  
Yan Liu ◽  
Mingmao Chen ◽  
Shuaihua Wang ◽  
Jingjing Lin ◽  
Lizhen Cai ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Insight Into

Insight into the interaction between chitosan and bovine serum albumin

2017 ◽  
Vol 176 ◽  
pp. 75-82 ◽  
Author(s):  
Guo Li ◽  
Jianying Huang ◽  
Tao Chen ◽  
Xiangyang Wang ◽  
Haijiang Zhang ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Insight Into

An insight into the inhibition of fibrillation process verses disaggregation of preformed fibrils of bovine serum albumin by isoprenaline hydrochloride

2020 ◽  
Vol 154 ◽  
pp. 1448-1459 ◽  
Author(s):  
Tajalli Ilm Chandel ◽  
Mariyam Afghani ◽  
Aiman Masroor ◽  
Ibrar Ahmad Siddique ◽  
Syed Mohammad Zakariya ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Insight Into

A novel amalgamation of deep eutectic solvents and crowders as biocompatible solvent media for enhanced structural and thermal stability of bovine serum albumin

2020 ◽  
Vol 22 (42) ◽  
pp. 24410-24422
Author(s):  
Kavya Bhakuni ◽  
Niketa Yadav ◽  
Pannuru Venkatesu
Keyword(s):  
Thermal Stability ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Deep Eutectic Solvents ◽  
Solvent Medium ◽  
Thermal Stability Of

This study unravels the effect of a novel solvent medium designed by amalgamation of macromolecular crowders and deep eutectic solvents (DESs) on bovine serum albumin (BSA).

Heteroprotein complex formation of bovine serum albumin and lysozyme: Structure and thermal stability

2018 ◽  
Vol 74 ◽  
pp. 267-274 ◽  
Author(s):  
Monique Barreto Santos ◽  
Carlos Wanderlei Piler de Carvalho ◽  
Edwin Elard Garcia-Rojas
Keyword(s):  
Thermal Stability ◽  
Bovine Serum Albumin ◽  
Complex Formation ◽  
Serum Albumin ◽  
Bovine Serum

New Insight into Molecular Interactions of Imidazolium Ionic Liquids with Bovine Serum Albumin

2011 ◽  
Vol 115 (42) ◽  
pp. 12306-12314 ◽  
Author(s):  
Yang Shu ◽  
Menglin Liu ◽  
Shuai Chen ◽  
Xuwei Chen ◽  
Jianhua Wang
Keyword(s):  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Molecular Interactions ◽  
Bovine Serum ◽  
Imidazolium Ionic Liquids ◽  
Insight Into

scholarly journals Insight into the interaction between α-lapachone and bovine serum albumin employing a spectroscopic and computational approach

2016 ◽  
Vol 5 (1) ◽  
pp. 331-339 ◽  
Author(s):  
Otávio Augusto Chaves ◽  
Edgar Schaeffer ◽  
Carlos Maurício R. Sant'Anna ◽  
José Carlos Netto-Ferreira ◽  
Dari Cesarin-Sobrinho ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Spectroscopic Studies ◽  
The Body ◽  
Amino Acid Residues ◽  
Pharmacological Activities ◽  
Number Of Binding Sites ◽  
Insight Into

Serum albumin is the most abundant protein in blood plasma; among its functions is the transport of a high variety of drugs in the body. Quinones show several biological and pharmacological activities, such as anti-malarial, antitumor, anti-microbial, anti-inflammatory and anti-parasitic. We report fluorescence and circular dichroism (CD) spectroscopic studies to try to understand the interaction process between α-lapachone (α-LAP) and bovine serum albumin (BSA). Studies using computational methods, such as molecular docking, were performed to identify the main cavity in which this interaction occurs as well as the type of intermolecular interactions between the amino acid residues from albumin and the ligand. The BSA fluorescence quenching by added α-LAP is a static process, indicating an initial association BSA: α-LAP. The Ka and Kb values for the interaction BSA: α-LAP are in the range 105-104 L∙mol-1, indicating a strong binding between these two species. CD data show that there is no significant perturbation on the secondary structure of the protein with binding. The negative ΔGo values are consistent with spontaneous binding occurring endothermically (ΔHo = 127 kJ∙mol-1), and possibly driven by hydrophobic factors (ΔSo = 0.526 kJ∙mol-1∙s-1). The number of binding sites (n) indicates the existence of just one main binding site in BSA for α-LAP, with molecular docking results showing that it binds preferentially to the albumin in the domain IIA, where the Trp-212 residue is located. The ligand interacts via hydrogen bond with Arg-259 and Tyr-149 residues and via T-stacking with the fluorophore Trp-212 residue.

Construing the interactions between MnO2 nanoparticle and bovine serum albumin: insight into the structure and stability of a protein–nanoparticle complex

2017 ◽  
Vol 41 (16) ◽  
pp. 8130-8139 ◽  
Author(s):  
Ayonbala Baral ◽  
Lakkoji Satish ◽  
Dipti P. Das ◽  
Harekrushna Sahoo ◽  
Malay K. Ghosh
Keyword(s):  
Experimental Investigation ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Structure And Stability ◽  
Insight Into ◽  
Nanoparticle Complex

Systematic experimental investigation of MnO2–BSA complexes in terms of the structure and stability of the protein as well as the aggregation of the nanoparticle.

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