Silencing of FTS increases radiosensitivity by blocking radiation-induced Notch1 activation and spheroid formation in cervical cancer cells

2019 ◽  
Vol 126 ◽  
pp. 1318-1325 ◽  
Author(s):  
D.S. Prabakaran ◽  
Sridhar Muthusami ◽  
T. Sivaraman ◽  
Jae-Ran Yu ◽  
Woo-Yoon Park
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Spheroid Formation ◽  
Cervical Cancer Cells ◽  
Radiation Induced

scholarly journals Retraction: Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5021-5021
Author(s):  
Laura Fisher
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Down Regulation ◽  
Cervical Cancer Cells ◽  
Radiation Induced

Retraction of ‘Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells’ by Yunxiang Qi et al., RSC Adv., 2020, 10, 1132–1141, DOI: 10.1039/C9RA04962B.

scholarly journals MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis

2015 ◽  
Vol 33 (6) ◽  
pp. 2853-2862 ◽  
Author(s):  
SHA LIU ◽  
XIAOFEN PAN ◽  
QIN YANG ◽  
LU WEN ◽  
YAO JIANG ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cervical Cancer Cells ◽  
Radiation Induced ◽  
Induced Apoptosis

scholarly journals Effect of Pentoxifylline on Radiation-Induced G 2 -Phase Delay and Radiosensitivity of Human Colon and Cervical Cancer Cells

1998 ◽  
Vol 149 (4) ◽  
pp. 338 ◽  
Author(s):  
Ye-Xiong Li ◽  
Kerstin Weber-Johnson ◽  
Lin-Quan Sun ◽  
Nicolas Paschoud ◽  
René-Olivier Mirimanoff ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Phase Delay ◽  
Cervical Cancer Cells ◽  
Radiation Induced

scholarly journals SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Songyan Wang ◽  
Cliff J. Luke ◽  
Stephen C. Pak ◽  
Victoria Shi ◽  
Liyun Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Protease Inhibitor ◽  
Cancer Cells ◽  
Cathepsin L ◽  
Cysteine Protease Inhibitor ◽  
Knock Out ◽  
Lysosomal Protease ◽  
Cervical Cancer Cells ◽  
Radiation Induced

AbstractThe endogenous lysosomal cysteine protease inhibitor SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) is elevated in patients with cervical cancer and other malignancies. High serum SERPINB3 is prognostic for recurrence and death following chemoradiation therapy. Cervical cancer cells genetically lacking SERPINB3 are more sensitive to ionizing radiation (IR), suggesting this protease inhibitor plays a role in therapeutic response. Here we demonstrate that SERPINB3-deficient cells have enhanced sensitivity to IR-induced cell death. Knock out of SERPINB3 sensitizes cells to a greater extent than cisplatin, the current standard of care. IR in SERPINB3 deficient cervical carcinoma cells induces predominantly necrotic cell death, with biochemical and cellular features of lysoptosis. Rescue with wild-type SERPINB3 or a reactive site loop mutant indicates that protease inhibitory activity is required to protect cervical tumor cells from radiation-induced death. Transcriptomics analysis of primary cervix tumor samples and genetic knock out demonstrates a role for the lysosomal protease cathepsin L in radiation-induced cell death in SERPINB3 knock-out cells. These data support targeting of SERPINB3 and lysoptosis to treat radioresistant cervical cancers.

The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells

Tumor Biology ◽  
2015 ◽  
Vol 37 (3) ◽  
pp. 4083-4091 ◽  
Author(s):  
Zongyan Chen ◽  
Benli Wang ◽  
Feifei Yu ◽  
Qiao Chen ◽  
Yuxi Tian ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Autophagic Cell Death ◽  
Cervical Cancer Cells ◽  
Radiation Induced

scholarly journals Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 1132-1141
Author(s):  
Yunxiang Qi ◽  
Jinyi Lang ◽  
Xiaodong Zhu ◽  
Jianming Huang ◽  
Lu Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Prognostic Factor ◽  
Cancer Cells ◽  
Squamous Carcinoma ◽  
Independent Prognostic Factor ◽  
Down Regulation ◽  
Cervical Cancer Cells ◽  
Radiation Induced

The phosphorylation of EGFRThr654 is required for nuclear EGFR importing, and our previous study has shown that pEGFRThr654 is an independent prognostic factor for the low survival rate of patients with cervical squamous carcinoma.

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