Sequential drug delivery of vancomycin and rhBMP-2 via pore-closed PLGA microparticles embedded photo-crosslinked chitosan hydrogel for enhanced osteointegration

The present manuscript reports the ultrasound radiation induced synthesis of grafted chitosan hydrogels (CAAT and CAAG) using terephthalaldehyde/glutaraldehyde as crosslinking agents and its application for removal of synthetic dyes from...

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Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2016.05.077 ◽

2016 ◽

Vol 91 ◽

pp. 85-91 ◽

Cited By ~ 40

Author(s):

Qiong Jiang ◽

Wei zhou ◽

Jun Wang ◽

Rupei Tang ◽

Di Zhang ◽

...

Keyword(s):

Wound Dressing ◽

Chitosan Hydrogel ◽

Crosslinked Chitosan ◽

Hydrogel Films

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Studies on dynamic behavior of water in crosslinked chitosan hydrogel

Journal of Applied Polymer Science ◽

10.1002/(sici)1097-4628(19980207)67:6<983::aid-app3>3.0.co;2-i ◽

1998 ◽

Vol 67 (6) ◽

pp. 983-988 ◽

Cited By ~ 18

Author(s):

Guo-Xiang Cheng ◽

Jing Liu ◽

Ren-Zhe Zhao ◽

Kang-De Yao ◽

Ping-Chuan Sun ◽

...

Keyword(s):

Dynamic Behavior ◽

Chitosan Hydrogel ◽

Crosslinked Chitosan

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Efficient removal and recycle of acid blue 93 dye from aqueous solution by acrolein crosslinked chitosan hydrogel

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2021.127825 ◽

2021 ◽

pp. 127825

Author(s):

Yun Liu ◽

Yue-Fei Zhang ◽

Jian Tang ◽

Yuting Tan ◽

Hang Lei ◽

...

Keyword(s):

Aqueous Solution ◽

Efficient Removal ◽

Chitosan Hydrogel ◽

Crosslinked Chitosan ◽

Acid Blue

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PLA and PLGA microparticles for intravitreal drug delivery: an overview

Journal of Drug Delivery Science and Technology ◽

10.1016/s1773-2247(07)50002-x ◽

2007 ◽

Vol 17 (1) ◽

pp. 11-17 ◽

Cited By ~ 11

Author(s):

R. Herrero-Vanrell ◽

I.T. Molina-Martinez

Keyword(s):

Drug Delivery ◽

Intravitreal Drug Delivery ◽

Plga Microparticles

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Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review

Veterinární Medicína ◽

10.17221/161/2018-vetmed ◽

2019 ◽

Vol 64 (No. 7) ◽

pp. 287-293

Author(s):

J Matejkova ◽

P Podhorec

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery System ◽

Delivery System ◽

Hormonal Treatment ◽

The United States ◽

Pharmaceutical Products ◽

European Medicines Agency ◽

Sustained Drug Delivery ◽

Plga Microparticles

Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning in species with asynchronous or multiple batch group synchronous ovarian physiology. The most recent development is the incorporation of GnRHa into microparticles of biodegradable polymers that release the drug during a certain period of time ranging from days to weeks. The most attractive polymeric candidate used as a carrier for administering a pharmaceutical products is poly(lactic-co-glycolic acid); (PLGA). PLGA has excellent biodegradability and biocompatibility and is generally recognised as safe by international regulatory agencies including the European Medicines Agency and the United States Food and Drug Administration. This review describes methods of hormonal treatment in fish, highlights the advantage of sustained drug delivery system and discusses the potential of PLGA microparticles as a tool for achieving successful reproduction.

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