Endothelial dysfunction, ADMA and insulin resistance in essential hypertension

Patients and methods. The authors have conducted clinical, functional and laboratory examination of 104 adolescents aged 11-18 years with a primary abdominal obesity type. It was additionally studied the reaction of the brachial artery in the process of conducting endothelial test with reactive hyperemia and calculated of percentage flow-mediated dilation (%FMD). Results. In 66% (n=67) cases it was identified endothelial dysfunction vessel (EDV) among adolescents on the basis of positive endothelial samples (FMD<10%). A further analysis was performed among children with dysfunction of endothelium of the brachial artery. The children were divided into 2 groups: children with essential hypertension and EDV and children without essential hypertension and EDV. Adolescents with essential hypertension had a moderate increase in the percentage content of fat mass (M=31,4±4,7%) and metabolic disorders in the blood are recorded with a frequency: hyperglycemia – 16,6%, ВЕСТНИК НОВЫХ МЕДИЦИНСКИХ ТЕХНОЛОГИЙ – 2015 – № 4 Электронный журнал Библиографическая ссылка: Маскова Г.С., Черная Н.Л., Дадаева О.Б. Патогенетические варианты развития дисфункции эндотелия сосудов у подростков с ожирением // Вестник новых медицинских технологий. Электронное издание. 2015. №4. Публикация 2-4. URL: http://www.medtsu.tula.ru/VNMT/Bulletin/E2015-4/5216.pdf (дата обращения: 18.11.2015). DOI:12737/14921 hypercholesterolemia – 4%, hyperinsulinemia – 27% and insulin resistance – 17%. Children without essential hypertension were characterized by significantly more pronounced metabolic disorders in the blood. In particular, hyperglycemia was reported among 33% of adolescents (p=0,04), hypercholesterolemia among 33% (p=0,04), hyperinsulinemia- 45% (p=0,041) and insulin resistance among 30% (p=0,042). Metabolic disorders of blood were registered at a higher percentage of body fat in the body (M=39,45±4,4%). Conclusion. The results analysis of the selected groups allows to reveal a predominant factor that causes dysfunction of endothelium among adolescents with obesity (high systemic blood pressure or hyperinsulinemia), as well as to determine the pathogenetic variants of further progress obesity: the development essential hypertension or increase metabolic disorders with the formation of diabetes type 2.

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W09.220 Endothelial dysfunction in subjects with early stages of the metabolic syndrome. Association with visceral adiposity and insulin resistance

Atherosclerosis ◽

10.1016/s0021-9150(04)90219-5 ◽

2004 ◽

Vol 5 (1) ◽

pp. 51

Author(s):

R GILABERT

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Endothelial Dysfunction ◽

Visceral Adiposity ◽

Early Stages ◽

The Metabolic Syndrome ◽

Syndrome Association

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Relation of insulin resistance and left ventricular function and structure in non-diabetic patients with essential hypertension

Acta Cardiologica ◽

10.2143/ac.60.2.2005031 ◽

2005 ◽

Vol 60 (2) ◽

pp. 191-198 ◽

Cited By ~ 13

Author(s):

Harun EVRENGUL ◽

Dursun DURSUNOGLU ◽

Asuman KAFTAN ◽

Fethi KILICASLAN ◽

Halil TANRIVERDI ◽

...

Keyword(s):

Insulin Resistance ◽

Essential Hypertension ◽

Left Ventricular Function ◽

Ventricular Function ◽

Left Ventricular ◽

Diabetic Patients

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Endothelial Dysfunction, Obesity and Insulin Resistance

Current Vascular Pharmacology ◽

10.2174/1570161112666140423221008 ◽

2014 ◽

Vol 12 (3) ◽

pp. 412-426 ◽

Cited By ~ 85

Author(s):

Dolores Prieto ◽

Cristina Contreras ◽

Ana Sanchez

Keyword(s):

Insulin Resistance ◽

Endothelial Dysfunction

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Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666180220114322 ◽

2018 ◽

Vol 18 (4) ◽

pp. 401-406 ◽

Cited By ~ 1

Author(s):

Cem Haymana ◽

Aydogan Aydogdu ◽

Ibrahim Demirci ◽

Mustafa Dinc ◽

Orhan Demir ◽

...

Keyword(s):

Insulin Resistance ◽

Endothelial Dysfunction ◽

Klinefelter Syndrome

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Magnesium intake, insulin resistance and markers of endothelial function among women

Public Health Nutrition ◽

10.1017/s1368980021001063 ◽

2021 ◽

pp. 1-9

Author(s):

Narges Ghorbani Bavani ◽

Parvane Saneei ◽

Ammar Hassanzadeh Keshteli ◽

Ahmadreza Yazdannik ◽

Ebrahim Falahi ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Endothelial Dysfunction ◽

Endothelial Function ◽

Adhesion Molecule ◽

Cell Function ◽

Intercellular Adhesion Molecule ◽

Model Assessment ◽

Serum Concentrations ◽

Homeostasis Model Assessment

Abstract Objective: We investigated the association of dietary Mg intake with insulin resistance and markers of endothelial function among Iranian women. Design: A cross-sectional study. Setting: Usual dietary intakes were assessed using a validated FFQ. Dietary Mg intake was calculated by summing up the amount of Mg in all foods. A fasting blood sample was taken to measure serum concentrations of glycemic indices (fasting plasma glucose and insulin) and endothelial function markers (E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1). Insulin resistance and sensitivity were estimated using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), Homeostasis Model Assessment β-cell function (HOMA-β) and quantitative insulin sensitivity check index (QUICKI). Participants: Iranian female nurses (n 345) selected by a multistage cluster random sampling method. Results: The Mg intake across energy-adjusted quartiles was 205 (se 7), 221·4 (se 8), 254·3 (se 7) and 355·2 (se 9) mg/d, respectively. After adjustments for potential confounders, QUICKI level was significantly different across quartiles of Mg intake (Q1: 0·34 (se 0·02), Q2: 0·36 (se 0·01), Q3: 0·40 (se 0·01), and Q4: 0·39 (se 0·02), P = 0·02); however, this association disappeared after considering markers of endothelial function, indicating that this relation might be mediated through endothelial dysfunction. After controlling for all potential confounders, Mg intake was inversely, but not significantly, associated with serum concentrations of sICAM (Q1: 239 (se 17), Q2: 214 (se 12), Q3: 196 (se 12), and Q4: 195 (se 17), P = 0·29). There was no other significant association between dietary Mg intake and other indicators of glucose homoeostasis or endothelial markers. Conclusions: Higher dietary Mg intake was associated with better insulin sensitivity in Iranian females. This linkage was mediated through reduced endothelial dysfunction.

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We-W34:4 Endothelial dysfunction predicts type 2 diabetes in essential hypertension

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)81257-2 ◽

2006 ◽

Vol 7 (3) ◽

pp. 313

Author(s):

R. Maio ◽

M. Vatrano ◽

G. Iemma ◽

A. Sciacqua ◽

F. Borrello ◽

...

Keyword(s):

Type 2 Diabetes ◽

Essential Hypertension ◽

Endothelial Dysfunction

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Comparison of biomarkers of endothelial dysfunction and microvascular endothelial function in patients with primary aldosteronism and essential hypertension

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320321999491 ◽

2021 ◽

Vol 22 (1) ◽

pp. 147032032199949

Author(s):

Miaomiao Sang ◽

Yu Fu ◽

Chenmin Wei ◽

Jing Yang ◽

Xueting Qiu ◽

...

Keyword(s):

Essential Hypertension ◽

Endothelial Dysfunction ◽

Endothelial Function ◽

Primary Aldosteronism ◽

Cardiovascular Events ◽

Statistical Significance ◽

Enzyme Linked Immunosorbent Assay ◽

Microvascular Endothelial ◽

Pai 1 ◽

Microvascular Endothelial Function

Introduction: Studies have shown that primary aldosteronism (PA) has a higher risk of cardiovascular events than essential hypertension (EH). Endothelial dysfunction is an independent predictor of cardiovascular events. Whether PA and EH differ in the endothelial dysfunction is uncertain. Our study was designed to investigate the levels of biomarkers of endothelial dysfunction (Asymmetric dimethylarginine, ADMA; E-selectin, and Plasminogen activator inhibitor-1, PAI-1) and assess the microvascular endothelial function in patients with PA and EH, respectively. Methods: The biomarkers of endothelial dysfunction were measured by enzyme-linked immunosorbent assay (ELISA). Microvascular endothelial function was evaluated by Pulse amplitude tonometry (PAT). Results: Thirty-one subjects with EH and 36 subjects with PA including 22 with aldosterone-producing adenoma (APA) and 14 with idiopathic hyperaldosteronism (IHA) were enrolled in our study. The ADMA levels among the three groups were different (APA 47.83 (27.50, 87.74) ng/ml vs EH 25.08 (22.44, 39.79) ng/ml vs IHA 26.00 (22.23, 33.75) ng/ml; p = 0.04), however, when the APA group was compared with EH and IHA group, there was no statistical significance (47.83 (27.50, 87.74) ng/ml vs 25.08 (22.44, 39.79) ng/ml for EH, p = 0.11; 47.83 (27.50, 87.74) ng/ml vs IHA 26.00 (33.75) ng/ml, p = 0.07). The results of ADMA levels are presented as Median (p25, p75). Whereas, levels of PAI-1 and E-selectin, microvascular endothelial function were not significantly different between PA and EH subjects. Conclusions: Our study shows no significant differences between PA and EH in terms of biomarkers of endothelial dysfunction and microvascular endothelial function. The microvascular endothelial function of PA and EH patients is comparable.

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