Fetal nucleated red blood cells in maternal peripheral blood and gestational age

In general, there is a reversal of the normal in the ratio of clasmatocytes in the spleen to clasmatocytes in the bone marrow in pernicious anemia, with a marked tendency toward the phagocytosis of young, immature, nucleated red blood cells in the bone marrow. The peripheral blood picture suggests that these cells had never been in circulation. The observations made do not indicate that the spleen takes any directly active part in an increased destruction of blood in pernicious anemia.

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SIGNIFICANCE OF NUCLEATED RED BLOOD CELLS IN PERIPHERAL BLOOD

Journal of the American Medical Association ◽

10.1001/jama.1954.02940500019007 ◽

1954 ◽

Vol 154 (16) ◽

pp. 1339 ◽

Cited By ~ 43

Author(s):

Steven O. Schwartz

Keyword(s):

Red Blood Cells ◽

Peripheral Blood ◽

Blood Cells ◽

Nucleated Red Blood Cells

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Persistent nucleated red blood cells in peripheral blood is a poor prognostic factor in patients with multiple organ failure

Clinical & Laboratory Haematology ◽

10.1111/j.1365-2257.2006.00760.x ◽

2006 ◽

Vol 28 (2) ◽

pp. 145-145 ◽

Cited By ~ 4

Author(s):

J. F. Lesesve ◽

P. Bordigoni ◽

P. Maurer ◽

T. Lecompte

Keyword(s):

Prognostic Factor ◽

Multiple Organ Failure ◽

Red Blood Cells ◽

Organ Failure ◽

Peripheral Blood ◽

Blood Cells ◽

Multiple Organ ◽

Poor Prognostic Factor ◽

Nucleated Red Blood Cells

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Beta-Thalassemia: Analysis of Mrna Precursors of a Mutant Human Globin Gene with Defective Splicing Using Peripheral Blood Nucleated Red Blood Cells

Hemoglobin ◽

10.3109/03630268609036562 ◽

1986 ◽

Vol 10 (6) ◽

pp. 573-586 ◽

Cited By ~ 4

Author(s):

Ariella Qppenheim ◽

Alice Karsai ◽

Richard Treisman ◽

Eitan Fibach ◽

Aliza Treves ◽

...

Keyword(s):

Red Blood Cells ◽

Peripheral Blood ◽

Blood Cells ◽

Globin Gene ◽

Beta Thalassemia ◽

Nucleated Red Blood Cells

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The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome

Frontiers in Medicine ◽

10.3389/fmed.2021.665410 ◽

2021 ◽

Vol 8 ◽

Author(s):

Jingang Zhang ◽

Kang Tang ◽

Yun Zhang ◽

Ying Ma ◽

Chunmei Zhang ◽

...

Keyword(s):

Red Blood Cells ◽

Disease Severity ◽

Peripheral Blood ◽

Blood Cells ◽

Expression Profiles ◽

Hemorrhagic Fever ◽

Hantaan Virus ◽

Pathological Changes ◽

Hematological Indices ◽

Nucleated Red Blood Cells

Hemorrhagic fever with renal syndrome (HFRS) is a regional infectious disease of epidemic potential caused by the Hantaan virus (HTNV). Red blood cells (RBCs) are the major components of peripheral blood. However, pathological changes in RBCs and the underlying mechanisms during HTNV infection remain largely unclear. Therefore, this study sought to explore changes in RBCs in the peripheral blood of HFRS patients. We isolated PBMCs from HFRS patients and performed single-cell RNA sequencing. The results showed that clusters of RBCs in the peripheral blood of HFRS could be classified as nucleated red blood cells (NRBC) based on their cellular components, gene expression profiles and cell surface markers. In addition, it was shown that the higher the count of NRBC in peripheral blood, the more severe the disease status was. Moreover, hematological indices related to RBCs were analyzed and the results showed that impairment in the folate pathway might be the possible reason behind the presence of NRBCs. This study, for the first time showed that the presence of NRBCs in the peripheral blood of HFRS patients was associated with disease severity. This was also the first study to show that infection with the HTNV virus hindered the maturation of RBCs. Therefore, this work provides further insights on the role of and pathological changes in RBCs during HTNV infection.

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