scholarly journals Perfluorobutanoic acid (PFBA): No high-level accumulation in human lung and kidney tissue

2021 ◽  
Vol 237 ◽  
pp. 113830
Author(s):  
Klaus Abraham ◽  
Ahmed H. El-Khatib ◽  
Tanja Schwerdtle ◽  
Bernhard H. Monien
Keyword(s):  
Human Lung ◽  
Kidney Tissue ◽  
High Level ◽  
Lung And Kidney

Expression of membrane-bound carbonic anhydrase in developing human lung and kidney

1989 ◽  
Vol 17 (6) ◽  
pp. 1122-1123
Author(s):  
NICK CARTER ◽  
ANTHONY FRYER ◽  
ROBERT HUME ◽  
RICHARD STRANGE ◽  
PER WISTRAND
Keyword(s):  
Carbonic Anhydrase ◽  
Human Lung ◽  
Membrane Bound ◽  
Lung And Kidney

scholarly journals Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2

2020 ◽  
Vol 11 ◽  
Author(s):  
Ching-Yuan Wu ◽  
Yu-Shih Lin ◽  
Yao-Hsu Yang ◽  
Li-Hsin Shu ◽  
Yu-Ching Cheng ◽  
...  
Keyword(s):  
Protein Expression ◽  
Hepg2 Cells ◽  
Kidney Tissue ◽  
Herbal Formula ◽  
Angiotensin Converting Enzyme 2 ◽  
Mrna And Protein Expression ◽  
Almost All ◽  
Lung And Kidney

Outbreak of coronavirus disease 2019 occurred in Wuhan and has rapidly spread to almost all parts of world. GB-1, the herbal formula from Tian Shang Sheng Mu of Chiayi Puzi Peitian Temple, is used for the prophylaxis of SARS-CoV-2 in Taiwan. In this study, we investigated that the effect of GB-1 and the index compounds of GB-1 on the ACE2 and TMPRSS2 expression through in vitro and in vivo study. In our result, GB-1 can inhibit ACE2 and TMPRSS2 protein expression in HepG2 cells, 293T cells, and Caco-2 cells without cytotoxicity. For the mouse model, GB-1 treatment could decrease ACE2 and TMPRSS2 expression levels of the lung and kidney tissue without adverse effects, including nephrotoxicity and hepatotoxicity. In the compositions of GB-1, 0.5–1 mg/ml of Glycyrrhiza uralensis Fisch. ex DC. extract could not inhibit ACE2 mRNA and protein expression in HepG2 cells. In addition, theaflavin-3-gallate could inhibit protein expression of ACE2 and TMPRSS2 without significant cytotoxicity. Our results suggest that GB-1 and theaflavin-3-gallate could act as potential candidates for prophylaxis or treatment of SARS-CoV-2 infection through inhibiting protein expression of ACE2 and TMPRSS2 for the further study.

scholarly journals High Level of Genetic Compatibility between Swine-Origin H1N1 and Highly Pathogenic Avian H5N1 Influenza Viruses

2010 ◽  
Vol 84 (20) ◽  
pp. 10918-10922 ◽  
Author(s):  
Cássio Pontes Octaviani ◽  
Makoto Ozawa ◽  
Shinya Yamada ◽  
Hideo Goto ◽  
Yoshihiro Kawaoka
Keyword(s):  
Influenza Virus ◽  
H5n1 Virus ◽  
Human Lung ◽  
Cultured Cells ◽  
Influenza Viruses ◽  
Compatibility Studies ◽  
Genetic Compatibility ◽  
Highly Pathogenic ◽  
H5n1 Influenza ◽  
High Level

Reassortment is an important mechanism for the evolution of influenza viruses. Here, we coinfected cultured cells with the pandemic swine-origin influenza virus (S-OIV) and a contemporary H5N1 virus and found that these two viruses have high genetic compatibility. Studies of human lung cell lines indicated that some reassortants had better growth kinetics than their parental viruses. We conclude that reassortment between these two viruses can occur and could create pandemic H5N1 viruses.

scholarly journals Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 129-134 ◽  
Author(s):  
Yoshiko Chuman ◽  
Ann-Charlotte Bergman ◽  
Takayuki Ueno ◽  
Shin'ichi Saito ◽  
Kazuyasu Sakaguchi ◽  
...  
Keyword(s):  
Kidney Tissue ◽  
Aspartic Protease ◽  
Normal Lung ◽  
Napsin A ◽  
Lung Adenocarcinomas ◽  
Lung And Kidney

scholarly journals RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects

DNA Repair ◽  
2016 ◽  
Vol 42 ◽  
pp. 44-55 ◽  
Author(s):  
Michelle C. Silva ◽  
Milagros D. Morrical ◽  
Katie E. Bryan ◽  
April M. Averill ◽  
Julie Dragon ◽  
...  
Keyword(s):  
Human Lung ◽  
Strand Exchange ◽  
Kidney Tumors ◽  
Dna Strand Exchange ◽  
Dna Strand ◽  
Lung And Kidney

scholarly journals Apoptosis correction in nephrotic children

2019 ◽  
pp. 15-19
Author(s):  
Ie. A. Burlaka ◽  
I.V. Bagdasarova
Keyword(s):  
Nephrotic Syndrome ◽  
Kidney Function ◽  
Kidney Tissue ◽  
Protective Effects ◽  
Controlling System ◽  
Clinical Investigations ◽  
Function Impairment ◽  
Apoptotic Marker ◽  
Nephrotic Children ◽  
High Level

Hypoxia-related disorders play an important role in irreversible kidney tissue damage via activation of certain secondary processes, i.e. apoptosis. This study aimed to investigate the levels of apoptosis controlling factors and nuclear transcriptional factor NF-κB in relation to the value of kidney function impairment; to evaluate possible protective effects of conventional therapy with the addition of an antioxidant agent tocopherol in pediatric patients with nephrotic syndrome. Methods. An examination of blood samples of 53 patients (aged 10 to 15 years) with nephrotic syndrome was performed. Conventional clinical investigations, immunoblotting were used in this study. Results. We demonstrate that nephrotic patients reveal a high level of pro-apoptotic marker Bax, low level of anti-apoptotic factor BcL-xL and anti-apoptotic unit of NF-κB (p65). Their dependence on level of kidney function impairment was detected.  Applied treatment composes conventional scheme and tocopherol shows a restored balance of apoptosis controlling factor and NF-κB activity.   Conclusion. Hypoxia-induces disorders in nephrotic children resulted in apoptosis controlling system disturbances can be attenuated by the antioxidants application.  

scholarly journals Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours

Oncogene ◽  
1998 ◽  
Vol 16 (23) ◽  
pp. 3083-3086 ◽  
Author(s):  
Sylvie Chevillard ◽  
J Pablo Radicella ◽  
Céline Levalois ◽  
Jérôme Lebeau ◽  
Marie-France Poupon ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Human Lung ◽  
Lung And Kidney

The effect of bilateral nephrectomy on the production and distribution of muramidase (lysozyme) in the rat

1970 ◽  
Vol 48 (2) ◽  
pp. 131-138 ◽  
Author(s):  
R. Keeler
Keyword(s):  
Kidney Tissue ◽  
High Plasma ◽  
Renal Tissue ◽  
Inhibitory Influence ◽  
Bilateral Nephrectomy ◽  
Venous Anastomosis ◽  
Rate Of Increase ◽  
Total Body ◽  
High Level

After bilateral nephrectomy total body muramidase in the rat increased by more than 50%. The mean rate of increase was 340 μg/h per 100 g. Skin and bone showed the greatest increase. Although the lungs contain a high level of muramidase there was no significant change in the level of enzyme activity after nephrectomy. Rats with sectioned ureters or with a uretero–venous anastomosis did not develop high plasma levels of muramidase. The response to nephrectomy is therefore not a response to uremia. Pretreatment of the animals with cortisone or DL-ethionine had no effect on the enzyme response to nephrectomy. This was taken to indicate that the response was not to antigenic material and did not depend upon hepatic synthesis of the enzyme. Pretreatment with the cytotoxic agent cyclophosphamide reduced the plasma and total body level of muramidase and blocked the response to nephrectomy. Direct measurement demonstrated a large increase in the rate of muramidase production by bone marrow. Since the in vitro inactivation of muramidase by kidney tissue could not be demonstrated, it is concluded that nephrectomy causes an increase in the rate of enzyme production rather than a failure of catabolism. Renal tissue might normally exert an inhibitory influence upon muramidase formation.

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