scholarly journals Haemoglobine S and C Protect Children Under Five 5 Years Living in the Saponé Health District (Burkina Faso) Against the Malaria Infection

2008 ◽  
Vol 12 ◽  
pp. e308-e309
Author(s):  
E.C. Bougouma
Keyword(s):  
Burkina Faso ◽  
Malaria Infection ◽  
Health District ◽  
Children Under Five ◽  
Under Five

scholarly journals Investigating host and parasite factors surrounding seasonal malaria chemoprevention in Bama, Burkina Faso

2020 ◽  
Author(s):  
Anyirékun Somé ◽  
Thomas Bazié ◽  
Ehrlich Hanna Y. ◽  
Justin Goodwin ◽  
Aine Lehane ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Malaria Infection ◽  
Large Scale ◽  
Plasma Concentrations ◽  
Dried Blood Spots ◽  
Children Under Five ◽  
Under Five ◽  
Blood Spots ◽  
Seasonal Malaria Chemoprevention ◽  
Parasite Factors

Abstract Background: Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) has been implemented on a large scale during the high malaria transmission season in Burkina Faso. We report in this paper the prevalence of microscopic and submicroscopic malaria infection at the outset and after the first round of SMC in children under five years old in Bama, Burkina Faso, as well as host and parasite factors involved in mediating the efficacy and tolerability of SMC. Methods: Two sequential cross-sectional surveys were carried out in the first month of SMC in a rural area in southwest Burkina Faso. Blood smears and dried blood spots were collected from 106 and 93 children under five, respectively, at the start of SMC and again three weeks later. Malaria infection was detected by microscopy and by PCR from dried blood spots. For all children, day 7 plasma concentrations of desethyl-amodiaquine (DEAQ) were measured and CYP2C8 genetic variants influencing AQ metabolism were genotyped. Samples were additionally genotyped for pfcrt K76T and pfmdr1 N86Y, molecular markers associated with reduced amodiaquine susceptibility. Results: 2.8% (3/106) of children were positive for Plasmodium falciparum infection by microscopy and 13.2% (14/106) by nested PCR within 2 days of SMC administration. Three weeks after SMC administration, in the same households, 4.3% (4/93) of samples were positive by microscopy and 14.0% (13/93) by PCR (p=0.0007). CYP2C8*2, associated with impaired amodiaquine metabolism, was common with an allelic frequency of 17.1% (95%CI=10.0-24.2). Day 7 concentration of DEAQ ranged from 0.48 to 362.80 ng/mL with a median concentration of 56.34 ng/mL. Pfmdr1 N86 predominated at both time points, whilst a non-significant trend towards a higher prevalence of pfcrt 76T was seen at week 3. Conclusion: This study showed a moderate prevalence of low-level malaria parasitemia in children 3 weeks following SMC during the first month of administration. Day 7 concentrations of the active DEAQ metabolite varied widely, likely reflecting variability in adherence and possibly metabolism. Our findings highlight factors that may contribute to the effectiveness of SMC in children in a high transmission setting.

scholarly journals Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso

2020 ◽  
Author(s):  
Anyirékun Somé ◽  
Thomas Bazié ◽  
Ehrlich Hanna Y. ◽  
Justin Goodwin ◽  
Aine Lehane ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Malaria Infection ◽  
Large Scale ◽  
Plasma Concentrations ◽  
Dried Blood Spots ◽  
Children Under Five ◽  
Under Five ◽  
Blood Spots ◽  
Seasonal Malaria Chemoprevention ◽  
Parasite Factors

Abstract Background: Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) has been implemented on a large scale during the high malaria transmission season in Burkina Faso. We report in this paper the prevalence of microscopic and submicroscopic malaria infection at the outset and after the first round of SMC in children under five years old in Bama, Burkina Faso, as well as host and parasite factors involved in mediating the efficacy and tolerability of SMC. Methods: Two sequential cross-sectional surveys were conducted in late July and August 2017 during the first month of SMC in a rural area in southwest Burkina Faso. Blood smears and dried blood spots were collected from 106 and 93 children under five, respectively, at the start of SMC and again three weeks later. Malaria infection was detected by microscopy and by PCR from dried blood spots. For all children, day 7 plasma concentrations of desethyl-amodiaquine (DEAQ) were measured and CYP2C8 genetic variants influencing AQ metabolism were genotyped. Samples were additionally genotyped for pfcrt K76T and pfmdr1 N86Y, molecular markers associated with reduced amodiaquine susceptibility. Results: 2.8% (3/106) of children were positive for Plasmodium falciparum infection by microscopy and 13.2% (14/106) by nested PCR within 2 days of SMC administration. Three weeks after SMC administration, in the same households, 4.3% (4/93) of samples were positive by microscopy and 14.0% (13/93) by PCR (p=0.0007). CYP2C8*2, associated with impaired amodiaquine metabolism, was common with an allelic frequency of 17.1% (95%CI=10.0-24.2). Day 7 concentration of DEAQ ranged from 0.48 to 362.80 ng/mL with a median concentration of 56.34 ng/mL. Pfmdr1 N86 predominated at both time points, whilst a non-significant trend towards a higher prevalence of pfcrt 76T was seen at week 3. Conclusion: This study showed a moderate prevalence of low-level malaria parasitemia in children 3 weeks following SMC during the first month of administration. Day 7 concentrations of the active DEAQ metabolite varied widely, likely reflecting variability in adherence and possibly metabolism. Our findings highlight factors that may contribute to the effectiveness of SMC in children in a high transmission setting.

scholarly journals Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso

2020 ◽  
Author(s):  
Anyirékun Somé ◽  
Thomas Bazié ◽  
Ehrlich Hanna Y. ◽  
Justin Goodwin ◽  
Aine Lehane ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Malaria Infection ◽  
Large Scale ◽  
Plasma Concentrations ◽  
Dried Blood Spots ◽  
Children Under Five ◽  
Under Five ◽  
Blood Spots ◽  
Seasonal Malaria Chemoprevention ◽  
Parasite Factors

Abstract Background: Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) has been implemented on a large scale during the high malaria transmission season in Burkina Faso. This paper reports the prevalence of microscopic and submicroscopic malaria infection at the outset and after the first round of SMC in children under five years old in Bama, Burkina Faso, as well as host and parasite factors involved in mediating the efficacy and tolerability of SMC. Methods: Two sequential cross-sectional surveys were conducted in late July and August 2017 during the first month of SMC in a rural area in southwest Burkina Faso. Blood smears and dried blood spots were collected from 106 and 93 children under five, respectively, at the start of SMC and again three weeks later. Malaria infection was detected by microscopy and by PCR from dried blood spots. For all children, day 7 plasma concentrations of desethylamodiaquine (DEAQ) were measured and CYP2C8 genetic variants influencing AQ metabolism were genotyped. Samples were additionally genotyped for pfcrt K76T and pfmdr1 N86Y, molecular markers associated with reduced amodiaquine susceptibility. Results: 2.8% (3/106) of children were positive for Plasmodium falciparum infection by microscopy and 13.2% (14/106) by nested PCR within 2 days of SMC administration. Three weeks after SMC administration, in the same households, 4.3% (4/93) of samples were positive by microscopy and 14.0% (13/93) by PCR (p=0.0007). CYP2C8*2, associated with impaired amodiaquine metabolism, was common with an allelic frequency of 17.1% (95%CI=10.0-24.2). Day 7 concentration of DEAQ ranged from 0.48 to 362.80 ng/mL with a median concentration of 56.34 ng/mL. Pfmdr1 N86 predominated at both time points, whilst a non-significant trend towards a higher prevalence of pfcrt 76T was seen at week 3. Conclusion: This study showed a moderate prevalence of low-level malaria parasitaemia in children 3 weeks following SMC during the first month of administration. Day 7 concentrations of the active DEAQ metabolite varied widely, likely reflecting variability in adherence and possibly metabolism. These findings highlight factors that may contribute to the effectiveness of SMC in children in a high transmission setting.

scholarly journals Association between Malaria Infection and Early Childhood Development Mediated by Anemia in Rural Kenya

2020 ◽  
Vol 17 (3) ◽  
pp. 902
Author(s):  
Erin M. Milner ◽  
Patricia Kariger ◽  
Amy J. Pickering ◽  
Christine P. Stewart ◽  
Kendra Byrd ◽  
...  
Keyword(s):  
At Risk ◽  
Social Development ◽  
Malaria Infection ◽  
Sub Saharan Africa ◽  
Gross Motor ◽  
Children Under Five ◽  
Under Five ◽  
Increased Risk ◽  
Social Delay ◽  
The Impact

Malaria is a leading cause of morbidity and mortality among children under five years of age, with most cases occurring in Sub-Saharan Africa. Children in this age group in Africa are at greatest risk worldwide for developmental deficits. There are research gaps in quantifying the risks of mild malaria cases, understanding the pathways linking malaria infection and poor child development, and evaluating the impact of malaria on the development of children under five years. We analyzed the association between malaria infection and gross motor, communication, and personal social development in 592 children age 24 months in rural, western Kenya as part of the WASH Benefits environmental enteric dysfunction sub-study. Eighteen percent of children had malaria, 20% were at risk for gross motor delay, 21% were at risk for communication delay, and 23% were at risk for personal social delay. Having a positive malaria test was associated with increased risk for gross motor, communication, and personal social delay while adjusting for child characteristics, household demographics, study cluster, and intervention treatment arm. Mediation analyses suggested that anemia was a significant mediator in the pathway between malaria infection and risk for gross motor, communication, and personal social development delays. The proportion of the total effect of malaria on the risk of developmental delay that is mediated by anemia across the subscales was small (ranging from 9% of the effect on gross motor development to 16% of the effect on communication development mediated by anemia). Overall, malaria may be associated with short-term developmental delays during a vulnerable period of early life. Therefore, preventative malaria measures and immediate treatment are imperative for children’s optimal development, particularly in light of projections of continued high malaria transmission in Kenya and Africa.

scholarly journals Assessment of the preferred methods used by mothers to prevent malaria infection among children under five years in the Hohoe Municipality of Ghana

2017 ◽  
Vol 2 (1) ◽  
pp. 25-34
Author(s):  
Martin Adjuik ◽  
Wisdom Takramah ◽  
Wisdom Kudzo Axame ◽  
Richard Owusu  ◽  
Phyllis Atta Parbey  ◽  
...  
Keyword(s):  
Malaria Infection ◽  
Children Under Five ◽  
Under Five

scholarly journals Prevalence and Determinants of Malaria Infection Among Children of local farmers in Central Malawi

2019 ◽  
Author(s):  
Emmanuel Chilanga ◽  
Delphine Collin-Vezina ◽  
Heather MacIntosh ◽  
Claudia Mitchel ◽  
Katrina Cherney
Keyword(s):  
Rural Areas ◽  
Partner Violence ◽  
Malaria Infection ◽  
Formal Education ◽  
National Level ◽  
Health Assessment ◽  
Cross Sectional ◽  
Children Under Five ◽  
Under Five ◽  
Age Range

Abstract BackgroundMalaria is a leading cause of morbidity and mortality among children under five in Malawi. Children from rural areas of central Malawi have high burden of malaria morbidity compared to other regions. The goals of this study were to examine the prevalence and determinants of malaria infection among children in rural areas of Dowa district in central Malawi.Methods A multistage cross-sectional study design was used to systematically sample 523 child-mother dyads from postnatal clinics. The main outcome was child positive malaria diagnostic test during postnatal clinic health assessment. Logistic regressions were used to determine risk factors associated with malaria among children aged 2 to 59 months.Results The prevalence of malaria amongst children under five years was 35.4%. The results of multivariable analyses show that children of mothers who experienced recent intimate partner violence (IPV) were more likely to be diagnosed with malaria ( AOR : 1.88, 95% CI : 1.19-2.97; P = 0.007) than children of mothers who did not. Children of mothers who had no formal education were more likely to be diagnosed with malaria ( AOR : 2.77, 95% CI : 1.24-6.19; P = 0.013) than children of mothers who attained secondary education. In addition, children in the age range of 2 to 5 months, and 6 to 11 months were less likely to be diagnosed with malaria ( AOR :0.21, 95% CI: 0.10-0.46; P = 0.000 and AOR :0.43; 95% CI: 0.22-0.85; P = 0.016, respectively) than children in the age range of 24 to 59 months.Conclusion The study found that the prevalence of malaria infection among children in the study area was comparable to that of national level. We propose that malaria control programs among children should also take into account mothers without formal education, mothers with children aged 24 to 59 months, and mothers that are experiencing IPV in the area.

scholarly journals Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso

2021 ◽  
Vol 38 ◽  
Author(s):  
Palpouguini Lompo ◽  
Marc Christian Tahita ◽  
Hermann Sorgho ◽  
William Christian Kaboré ◽  
Adama Kazienga ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Acute Diarrhea ◽  
Children Under Five ◽  
Under Five

scholarly journals Effect of Free Healthcare Policy for Children under Five Years Old on the Incidence of Reported Malaria Cases in Burkina Faso by Bayesian Modelling: “Not only the Ears but also the Head of the Hippopotamus”

2020 ◽  
Vol 17 (2) ◽  
pp. 417 ◽  
Author(s):  
Mady Ouédraogo ◽  
Toussaint Rouamba ◽  
Sékou Samadoulougou ◽  
Fati Kirakoya-Samadoulougou
Keyword(s):  
Burkina Faso ◽  
Negative Binomial ◽  
Malaria Incidence ◽  
Fold Increase ◽  
Healthcare Policy ◽  
Data Repository ◽  
Children Under Five ◽  
Under Five ◽  
Routine Surveillance ◽  
Free Healthcare

Burkina Faso has recently implemented an additional strategy, the free healthcare policy, to further improve maternal and child health. This policy targets children under five who bear the brunt of the malaria scourge. The effects of the free-of-charge healthcare were previously assessed in women but not in children. The present study aims at filling this gap by assessing the effect of this policy in children under five with a focus on the induced spatial and temporal changes in malaria morbidity. We used a Bayesian spatiotemporal negative binomial model to investigate the space–time variation in malaria incidence in relation to the implementation of the policy. The analysis relied on malaria routine surveillance data extracted from the national health data repository and spanning the period from January 2013 to December 2018. The model was adjusted for meteorological and contextual confounders. We found that the number of presumed and confirmed malaria cases per 1000 children per month increased between 2013 and 2018. We further found that the implementation of the free healthcare policy was significantly associated with a two-fold increase in the number of tested and confirmed malaria cases compared with the period before the policy rollout. This effect was, however, heterogeneous across the health districts. We attributed the rise in malaria incidence following the policy rollout to an increased use of health services combined with an increased availability of rapid tests and a higher compliance to the “test and treat” policy. The observed heterogeneity in the policy effect was attributed to parallel control interventions, some of which were rolled out at different paces and scales. Our findings call for a sustained and reinforced effort to test all suspected cases so that, alongside an improved case treatment, the true picture of the malaria scourge in children under five emerges clearly (see the hippopotamus almost entirely).

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