scholarly journals Epidemiological patterns of Hepatitis A infection during the pre-vaccination Era: A population-based survey in Tunisia in 2015

Author(s):  
Farah Saffar ◽  
Fatma Sellaoui ◽  
Aicha Hechaichi ◽  
Souhir Chelly ◽  
Hind Bouguerra ◽  
...  
2007 ◽  
Vol 14 (4) ◽  
pp. 269-273 ◽  
Author(s):  
Gaston De Serres ◽  
Bernard Duval ◽  
Ramak Shadmani ◽  
Isabelle Rouleau ◽  
Manale Ouakki ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e94622 ◽  
Author(s):  
Ricardo Arraes de Alencar Ximenes ◽  
Celina Maria Turchi Martelli ◽  
Marcos Amaku ◽  
Ana Marli C. Sartori ◽  
Patricia Coelho de Soárez ◽  
...  

2000 ◽  
Vol 124 (3) ◽  
pp. 459-466 ◽  
Author(s):  
F. TERMORSHUIZEN ◽  
J. W. DORIGO-ZETSMA ◽  
H. E. de MELKER ◽  
S. van den HOF ◽  
M. A. E. CONYN-VAN SPAENDONCK

The prevalence of antibodies to hepatitis A virus was assessed in a Dutch nationwide sample (n = 7367). A questionnaire was used to study the association with various sociodemographic characteristics. Overall, 33·8% (95% CI 31·6–36%) of the population had hepatitis A antibodies. The seroprevalence was less than 10% in people under 35; it increased from 25% at 35 years to 85% at 79 years. For those 15–49 years of age, Turks (90·9%) and Moroccans (95·8%) had greater seroprevalence than autochthonous Dutch (20·2%) and other Western people (25%). Low or middle socio-economic status, as indicated by the highest educational level achieved, was associated with greater seroprevalence, independently of age and reported immunization (OR 2·11 and 1·45; 95% CI 1·67–2·67 and 1·11–1·89, respectively). These data suggest autochthonous Dutch and other Westerners born after World War II were exposed to hepatitis A during childhood less frequently than older birth cohorts. Thus, more susceptibility is likely in the coming decades. Since this means a greater risk of outbreaks in future years, and since morbidity and mortality are more frequent in older persons, studying the cost effectiveness of selective and general vaccination might be worthwhile.


Author(s):  
Mohamed H Al-Thani ◽  
Elmoubasher Farag ◽  
Roberto Bertollini ◽  
Hamad Eid Al Romaihi ◽  
Sami Abdeen ◽  
...  

Abstract Background Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population who comprise 60% of the total population. This study aimed to assess ever and/or current infection prevalence in this population. Methods A cross-sectional population-based survey was conducted during July 26-September 09, 2020 to assess both anti-SARS-CoV-2 positivity through serological testing and current infection positivity through polymerase chain reaction (PCR) testing. Associations with antibody and PCR positivity were identified through regression analyses. Results Study included 2,641 participants, 69.3% of whom were <40 years of age. Anti-SARS-CoV-2 positivity was 55.3% (95% CI: 53.3-57.3%) and was significantly associated with nationality, geographic location, educational attainment, occupation, and previous infection diagnosis. PCR positivity was 11.3% (95% CI: 9.9-12.8%) and was significantly associated with nationality, geographic location, occupation, contact with an infected person, and reporting two or more symptoms. Infection positivity (antibody and/or PCR positive) was 60.6% (95% CI: 58.6-62.5%). The proportion of antibody-positive CMWs that had a prior SARS-CoV-2 diagnosis was 9.3% (95% CI: 7.9-11.0%). Only seven infections were ever severe and one was ever critical—an infection severity rate of 0.5% (95% CI: 0.2-1.0%). Conclusions Six in every 10 CMWs have been infected, suggestive of reaching the herd immunity threshold. Infection severity was low with only one in every 200 infections progressing to be severe or critical. Only one in every 10 infections had been previously diagnosed suggestive of mostly asymptomatic or mild infections.


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