Non-invasive mechanical ventilation in Australian emergency departments: A prospective observational cohort study

2009 ◽  
Vol 46 (5) ◽  
pp. 617-623 ◽  
Author(s):  
L. Rose ◽  
M.F. Gerdtz
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Study ◽  
Emergency Departments ◽  
Invasive Mechanical Ventilation ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Non Invasive ◽  
Observational Cohort

scholarly journals Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0238552
Author(s):  
Ana C. Monteiro ◽  
Rajat Suri ◽  
Iheanacho O. Emeruwa ◽  
Robert J. Stretch ◽  
Roxana Y. Cortes-Lopez ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Study ◽  
Smoking Status ◽  
Univariate Analysis ◽  
Invasive Mechanical Ventilation ◽  
Multivariable Analysis ◽  
Observational Cohort Study ◽  
Smoking History ◽  
Observational Cohort ◽  
Retrospective Observational Cohort Study

Purpose To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical ventilation (IMV). Materials and methods A retrospective, observational cohort study of 112 inpatient adults diagnosed with COVID-19 between March 12 and April 16, 2020. Data were manually extracted from electronic medical records. Multivariable and Univariable regression were used to evaluate association between baseline characteristics, initial serum markers and the outcome of IMV. Results Our cohort had median age of 61 (IQR 45–74) and was 66% male. In-hospital mortality was 6% (7/112). ICU mortality was 12.8% (6/47), and 18% (5/28) for those requiring IMV. Obesity (OR 5.82, CI 1.74–19.48), former (OR 8.06, CI 1.51–43.06) and current smoking status (OR 10.33, CI 1.43–74.67) were associated with IMV after adjusting for age, sex, and high prevalence comorbidities by multivariable analysis. Initial absolute lymphocyte count (OR 0.33, CI 0.11–0.96), procalcitonin (OR 1.27, CI 1.02–1.57), IL-6 (OR 1.17, CI 1.03–1.33), ferritin (OR 1.05, CI 1.005–1.11), LDH (OR 1.57, 95% CI 1.13–2.17) and CRP (OR 1.13, CI 1.06–1.21), were associated with IMV by univariate analysis. Conclusions Obesity, smoking history, and elevated inflammatory markers were associated with increased need for IMV in patients with COVID-19.

scholarly journals Absence of fear of dying predicts new organ failure: Results of a multicenter prospective observational cohort study

2021 ◽  
Author(s):  
Aurélien Mazeraud ◽  
Guillaume Turc ◽  
Sivanthiny Sivanandamoorthy ◽  
Raphaël Porcher ◽  
Annabelle Stoclin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Organ Failure ◽  
Invasive Mechanical Ventilation ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
State Trait Anxiety Inventory ◽  
Saps Ii ◽  
Item Questionnaire ◽  
Observational Cohort ◽  
Acute Anxiety

Abstract Rationale: Intensity of anxiety at admission in intensive care unit (ICU) is associated with subsequent deterioration.Objective: The primary aim of this study was to assess predictive value of stressful fears and feelings to predict new organ failure within the first seven days after ICU admission.Methods: We conducted a prospective three-center cohort study of non-comatose patients without delirium or invasive mechanical ventilation. A twelve-item questionnaire was developed to assess stressful fears and feelings. Illness severity was assessed using SAPS-II and SOFA scores. Intensity of chronic and acute anxiety was assessed with the ‘Trait’ and ‘State’ forms of the State-Trait Anxiety Inventory (STAI). Patients were followed-up for seven days. Results: From April 2014 to December 2017, 373 patients (median age, 63y.o. [49-74]; 159 [40.7%] women; SAPS-II 28 [19-37]) were included. Feeling of vulnerability and fear of dying was reported in 209 (54.4%) and 178 (46.4%) patients, respectively. STAI was equal or above 40 in 192 (51.5%) patients. Ninety-four (25.2%) patients developed a new organ failure. Feeling of vulnerability (OR=1.96, 95%CI:1.12-3.43], p=0.01) and absence of fear of dying (OR=2.38, 95%CI:1.37-4.17], p=0.002) were associated with occurrence of a new organ failure after adjustment on STAI ≥40, SAPS-II and SOFA. Conclusion: Absence of fear of dying is associated with occurrence of new organ failure within the seven post-ICU admission days. We hypothesize that fear of dying might be protective for subsequent deterioration by mobilizing patient’s homeostatic resources. Trial registration: NCT02355626

scholarly journals Obesity and Smoking as Risk Factors for Invasive Mechanical Ventilation in COVID-19: a Retrospective, Observational Cohort Study

2020 ◽  
Author(s):  
Ana Carolina Costa Monteiro ◽  
Rajat Suri ◽  
Ileanacho Obi Emeruwa ◽  
Robert J Stretch ◽  
Roxana Y Cortes Lopez ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Study ◽  
Smoking Status ◽  
Univariate Analysis ◽  
Invasive Mechanical Ventilation ◽  
Multivariable Analysis ◽  
Observational Cohort Study ◽  
Smoking History ◽  
Observational Cohort ◽  
Retrospective Observational Cohort Study

Purpose: To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical ventilation (IMV). Materials and Methods: A retrospective, observational cohort study of 112 inpatient adults diagnosed with COVID-19 between March 12 and April 16, 2020. Data were manually extracted from electronic medical records. Multivariable and Univariable regression were used to evaluate association between baseline characteristics, initial serum markers and the outcome of IMV. Results: Our cohort had median age of 61 (IQR 45-74) and was 66% male. In-hospital mortality was 6% (7/112). ICU mortality was 12.8% (6/47), and 18% (5/28) for those requiring IMV. Obesity (OR 5.82, CI 1.74-19.48), former (OR 8.06, CI 1.51-43.06) and current smoking status (OR 10.33, CI 1.43-74.67) were associated with IMV after adjusting for age, sex, and high prevalence comorbidities by multivariable analysis. Initial absolute lymphocyte count (OR 0.33, CI 0.11-0.96), procalcitonin (OR 1.27, CI 1.02-1.57), IL-6 (OR 1.17, CI 1.03-1.33), ferritin (OR 1.05, CI 1.005-1.11), LDH (OR 1.57, 95% CI 1.13-2.17) and CRP (OR 1.13, CI 1.06-1.21), were associated with IMV by univariate analysis. Conclusions: Obesity, smoking history, and elevated inflammatory markers were associated with increased need for IMV in patients with COVID-19.

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